Lue, whose essay described the regulation of alternative splicing and how defects in this process can cause disease, and Mueller, whose essay described examples of alternatively
spliced proteins coded by the same gene with different functions that act in different cells, will each receive a $ 400 prize, and their science teachers, Dr. Martina Davies and Mrs. Jessica Graham respectively, will each receive a $ 400 grant for genetics materials.
Not exact matches
By
splicing genes for the original
protein with ones that
code for
proteins containing different instructions, the researchers created a modified version of N - WASP.
Rbfox1
proteins were known to play a key role in
splicing together
coding portions of genes called exons to form mRNA, which is subsequently translated to form
proteins.
As a postdoc in the lab of Zefeng Wang, PhD, a member of the UNC Lineberger Comprehensive Cancer Center, Choudhury stumbled upon DAZAP1 while searching for
proteins involved in alternative
splicing — when a single gene organizes its genetic
code to create different
proteins with various functions.
A gene can
code for different
proteins — with diverse functionality — through the genetic mechanism of alternative
splicing (the cutting and rejoining of genes).
Alternative
splicing is a process of generating multiple transcripts and
protein variants by joining different combinations of
coding segments.
The cell
splices out the introns and joins up only those DNA sequences that
code for the
protein.
The mutation isn't in a region of the gene that
codes for the SMARCAD1
protein; instead it's near a key
splicing site that prevents SMARCAD1 from being made correctly, the researchers report today in The American Journal of Human Genetics.
The researchers learned that the astonishing diversity of cadherin in pink bollworm from India is caused by alternative
splicing, a novel mechanism of resistance that allows a single DNA sequence to
code for many variants of a
protein.
Activation of a gene induces a cell to make an RNA copy of its
code, edit unneeded segments out of that message, and
splice together a final version of the message that provides cellular factories (ribosomes) with a template to make one specific
protein.
Proteins are synthesized from instructions
coded in the DNA through a multi-step process that includes RNA
splicing.
Then, we prioritize variants that are predicted to have functional effects — on
protein coding, on
splicing, in conserved regions, etc..
Release 1.0 contains 15,419 high confidence
protein -
coding genes; alternatively
spliced transcripts derived from 992 genes add an additional 1,370
proteins yielding a total of 16,789 predicted
proteins.