Sentences with phrase «splicing as»

However, in that case there is no «innocent» explenation for the splicing as they needed to add knowingly those uncertainties to the data obtained from Mann's webpage.

«This is a really interesting result, and suggests that we might someday be able to use splicing as a kind of biomarker or early signature of aging,» says Heintz.

Sarah Polley is probably known best as an actress, starring in films such as Go, Dawn of the Dead (the 2004 remake) and Splice as well as a long stint on US TV series Avonlea as a child.

They proposed that the relevant comparandum for HadCRUT4 ought to be a splice as well: of TOS over ocean areas and TAS over land.

Not exact matches

Three separate work termsare spliced into the curriculum, giving studentsplacements with the school's partnersin the private and public sector.Degroote also offers a traditional 16 - monthMBA, as well as an eight - month acceleratedversion.

When Intuit used Splice in its telemarketing in India, the audio techniques that allowed the company to build more personalized telemarketing messages — using first names, varying tone of voice and employing user profiles — didn't quite take as it had in the U.S. and the U.K.

Lazarus malware families (like Hangman, Duuzer, Volgmer, SpaSpe, etc.) overlap, likely as the result of the developers cutting - and - splicing an extensive codebase of malicious functionality to generate payloads as needed.

Kids as young as 8 years old, swing machetes high over their heads to hack off cocoa pods, spray lethal pesticide without any protective gear, spend hours splicing open the pods with knives, with little clue that the end result of their labor is candy that will go on clearance by February 15th.

And the same is going to be true now as public interest shifts from nuclear physics to molecular biology, from the splitting of atoms to the splicing of genes.

(Ligases are enzymes that splice together other molecules such as DNA or RNA.)

In 1951 the late Willie Erwin, as fine a Peachtree Street cavalier as ever spliced the main brace with a julep, copped the SORC trophy with the PCC (Pacific Cruising Class) Belle of the West.

Dr. Murray Clarke, in his book «Natural Baby, Healthy Child» writes: «Obviously, these genetic mutations and splicings would never occur naturally and they are described by many prominent scientists as playing «Russian roulette» with our most important commodity, our food.

This process known as «alternative splicing» and allowing a single gene to generate multiple protein variants is especially prevalent in the mammalian brain.

Ribozymes derived from the self - splicing pre-ribosomal RNA of Tetrahymena act as sequence - specific endonucleases.

Nor is RNA quite so inert or structurally constrained as its cousin; its conformational versatility and catalytic abilities have been implicated at the very core of protein synthesis and possibly of RNA splicing.

In fact, he and his community of researchers in alternative RNA splicing — a field he helped to create — have shown that they can do world - class research despite tight government budgets and three - month delivery times for reagents that can cost three times as much as they would in the United States or Europe.

As a consequence of differential RNA splicing, mRNAs containing different combinations of exons can be produced from the same gene.

One way to get many types of cells or proteins from the same genetic starting material is by mixing and matching different parts of one gene to produce multiple gene readouts, a phenomenon known as alternative splicing.

Moore had spent her career studying the intricacies of how nascent mRNA gets spliced in the nucleus and loaded with proteins to become a complex known as a messenger ribonucleoprotein (mRNP).

In those cells the Esrp1 and Esrp2 proteins enforce epithelial - specific splicing isoforms for hundreds of different genes, as Carstens and his team have shown in studies since 2009.

In addition, the total amount of a protein can be regulated by alternative splicing, which is illustrated in the current work by using the general transcription factor TBP (TATA - box binding protein) as an example.

As sensitive as alternative splicing reacts to (slightly) elevated temperature, a temperature - induced change in gene expression by fever appears to be a logical consequencAs sensitive as alternative splicing reacts to (slightly) elevated temperature, a temperature - induced change in gene expression by fever appears to be a logical consequencas alternative splicing reacts to (slightly) elevated temperature, a temperature - induced change in gene expression by fever appears to be a logical consequence.

The science shows, but only as a seamlessly spliced element of plot structure: Eleanor's attraction to Piper's iconoclasm has monumental personal consequences.

In this memoir, paleontologists Walker and Shipman splice stories of their adventures excavating the animal with an analysis of its biology — as revealed by current research and by Mary Leakey, who discovered the first Proconsul skull in Kenya in 1948.

When a gene from a dangerous virus, such as rabies or measles, is spliced into the adenovirus genome, the immune system battles both the adenovirus and the inserted gene.

Furthermore, RNA can be spliced in various ways to make different proteins, but problems with splicing can lead to diseases such as spinal muscular atrophy, atypical cystic fibrosis and frontotemporal dementia (FTD).

To better understand how the process works, they focused on the large mobile DNAs, such as plasmids, which exist as free DNA circles apart from the bacterial chromosome, and genomic islands, which can splice themselves into the chromosome.

«While gene duplication and alternative splicing are typically invoked as major mechanisms underpinning protein neofunctionalization, this study suggests that the process of co-option should be re-evaluated as a potentially important method by which genes can acquire novel functions.»

Of the three pathways activated within the UPR, the new work implicates IRE1, which produces a molecule called spliced X-box binding protein 1 (Xbp1s), as a direct activator of the hexosamine biosynthetic pathway (HBP).

As a postdoc in the lab of Zefeng Wang, PhD, a member of the UNC Lineberger Comprehensive Cancer Center, Choudhury stumbled upon DAZAP1 while searching for proteins involved in alternative splicing — when a single gene organizes its genetic code to create different proteins with various functions.

Furthermore, we see these materials as important probes to dissect the complex yet important mechanics of disease related splicing events.

Short regions bordering the exons — known as splice sites — tell the cell where to cut and paste the mRNA.

«These splicing signatures could potentially be used as clinical biomarkers to detect blood stem cells that show signs of early aging or leukemia, and to monitor patient responses to treatment,» said Crews.

Crews noted that RNA splicing - targeted agents have been shown to have activity in a variety of solid tumors so the findings may be relevant to a variety of cancers, such as breast and drug - resistant melanoma.

The resulting parts are pieces of DNA with specific ends that act as targets for enzymes that cut and splice DNA.

They spliced the gene for this transporter protein into Escherichia coli bacteria and found it enabled the bacteria to pull in presynthesized X and Y bases as well.

In some prokaryotes as well as in the organelles of some eukaryotes, splicing can be self - catalyzed by particular ribozymes with the help of magnesium ions, without the intervention of any protein machinery: the group II introns ribozymes are in fact able to self - regulate their own removal from the filament, thus promoting the maturation of messenger RNA.

However, the panel noted, techniques other than gene - splicing, such as mutagenesis from radiation or chemicals, have a higher risk of creating genetic surprises.

The researchers utilized a technique known as exon skipping, a form of RNA splicing, to eliminate the portion of one of the IgE receptor gene's mRNA that is essential to making a protein which places the IgE receptor on the mast cell surface.

In biological systems in particular, this scale ‐ free addition of new nodes is likely a consequence of gene duplication (Qian et al, 2001), and is also affected by alternate splicing and posttranslational modification in protein networks (Qian et al, 2001; Bhan et al, 2002; Pastor ‐ Satorras et al, 2003; Vazquez et al, 2003), as well as the variable chemical versatility of the metabolic intermediates in metabolic networks.

EJCs are like chapter marks or tags deposited in the cell's nucleus as a gene's copied RNA message is edited, or spliced.

Many miRNA genes, therefore, lack annotated features such as a promoter or splice sites, hindering progress in understanding their transcriptional and post-transcriptional regulation.

Adding to the documented complexity of IL - 15 — related activity, multiple isoforms and splice variants of IL - 15Rα exist as both membrane - bound and soluble forms that can either inhibit or potentiate IL - 15 biological activity (29 — 33).

These diseases are referred to as splicing diseases and include SMA, cystic fibrosis and Duchenne's muscular dystrophy.

To study how splicing might affect aging, the researchers looked to Caenorhabditis elegans, a species of roundworm that's often used as a precursor to human tests in biological research, thanks to it having a genome very similar to ours.

I do like that the authors performed RNA - Seq of the transcriptome, which provides insights into mechanisms like alternative splicing (AS), allele - specific expression (ASE), and RNA editing.

Since the worms» cells are transparent, the team tagged the gene splicing with fluorescent proteins to help them visualize the process as the worms aged.

Now, a Harvard team has discovered a link between aging and a core biological process known as RNA splicing, which may be manipulated to not only increase our lifespan, but help us stay healthier for longer.

Taking in account the opposing phenotypes of Drosophila plin1 and plin2 loss of function regarding to lipid droplet size, it is intriguing to speculate that individual W01A8.1 splice forms may support distinct functions as well.

Several strategies have been pursued to increase the extent of exon 7 inclusion in the splicing of SMN2, for eventual use as therapeutics for SMA.