Sentences with phrase «splicing factors»
Splicing factors refer to proteins that help in a process called splicing. Splicing is when parts of our DNA molecules are connected to form a gene, which contains instructions for making proteins. So, splicing factors are like little helpers that ensure our genes are formed correctly. Full definition
Notably, the phosphorylated proteins included a group called splicing factors, which splice together different sections of messenger RNA, changing the proteins that they encode.
sciencedaily.com
As a postdoctoral fellow, he worked on the X-ray structure solution of several essential RNA splicing factor complexes as well as NMR solution structures of RNA splice sites.
He published the structure of splicing factor - 1, which is involved in mRNA splicing, and solved a three - dimensional structure of the PAZ domain of the Argonaute protein, which is involved in RNA interference pathways.
The study, titled «Rbfox Splicing Factors Promote Neuronal Maturation and Axon Initial Segment Assembly,» was published Feb. 1, ahead of print in Neuron.
[45] SF3B1 encodes subunit 1 of the RNA splicing factor 3b protein complex, but the functional consequences of its mutation remain to be fully elucidated.
HITS - CLIP, together with analysis of knockout mice and bioinformatic approaches, led to the discovery that the position of protein binding in the messenger RNA is a prime determinant of the outcome of alternative splicing or polyadenylation, general rules applicable to many splicing factors.
The first project focuses on frequent somatic mutations of any of several splicing factors that are found in patients with myelodysplastic syndrome or acute myeloid leukemia.
Wang Y, Cheong C - G, Hall TMT, Wang Z. Engineering splicing factors with designed specificities.
Further research focused on one particular part of the process called splicing factor 1 (SFA - 1), and found that increasing the levels of this component extended the lifespan of the worms.
«The effect on the splicing factors and other mutations associated with leukemia was completely surprising to me,» Klein said.
The splicing factor proline - glutamine rich (SFPQ / PSF) is involved in influenza virus transcription.
Yang Y, Hadjikyriacou A, Xia Z, Gayatri S, Kim D, Zurita - Lopez C, Kelly R, Guo A, Li W, Clarke SG, Bedford MT. (2015) PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145.
Research Interests: transcription; RNA processing; RNA splicing; splicing factors; relation to cancer and developmental diseases; gene structure and function; genomics; evolution of genomes; RNA biochemistry