Sentences with phrase «spontaneous mutations»

According to Robert Storr, «Bradford incrementally and provisionally charts an emerging and expansive reality while looking to a future in which the local and the regional dissolve into a new sublime that reproduces itself everywhere cities remake themselves and exceed their limits faster than planners can plan them or conventional cartographers can record their spontaneous mutations.»

As with all breeds that are developed from spontaneous mutations, there can be problems with weakened immune systems in cats that come from heavily inbred lines.

He might simply have fallen victim to one of those unfortunate spontaneous mutations that cause cancer, for which no satisfying explanation exists.

Factors such as local sequence context, replication timing, transcriptional status or paternal age at conception are known to bias the occurrence of spontaneous mutations.

The acquisition of growth signal self - sufficiency is one of the hallmarks of cancer.28 In this paper, we show that a broad spectrum of spontaneous mutations in one of the endogenous JAK1 alleles is the main mechanism that confers to BaF3 cells cytokine - independent growth capability in vitro and full tumorigenicity in vivo (Online Supplementary Figure S5), secondary to the upregulation of the JAK1 transcript.

Hypermotility in Clostridium perfringens Strain SM101 is Due to Spontaneous Mutations in Genes Linked to Cell Division.

The team identified hundreds of regions of the genome where spontaneous mutations are implicated in autism. Spontaneous mutations are those that arise for the first time in an individual, rather than being inherited from parents.

The findings not only validate the systematic approach to whole - genome sequencing in clinics, they also demonstrate that de novo mutations, otherwise known as spontaneous mutations not inherited by parents, are the main cause of this severe type of epilepsy.

Genetic analyses have shown that 90 percent of ALS cases are caused by spontaneous mutations that are not inherited.

The research team found a surprising variety of spontaneous mutations, from simple deletions or insertions to «jumping genes» — elements of DNA that copy and paste themselves into other parts of the genome.

Disorders may be inherited or develop from spontaneous mutations.

Most spontaneous mutations do neither harm nor good but simply accumulate in the genome, one at a time, as they are passed from one generation to the next.

Bacteria can become resistant to the antibiotic either as the result of a spontaneous mutation or by picking up an appropriate «resistance gene» (which codes for a protein that confers resistance) from another bacterium via genetic exchange.

Hutchinson - Gilford progeria is caused by a spontaneous mutation during conception in a gene called LMNA, which encodes a protein called prelamin A. Progeria patients experience a buildup of an abnormal version of prelamin A in their cells that, among other changes, distorts the nucleus and alters gene expression.

This specific spontaneous mutation, which we found in a sufficient number of cases, announced itself as an autism risk factor.»

This finding significantly enhances our understanding of how organisms use MMR to reduce spontaneous mutation rates.

Researchers from the University of North Carolina, Chapel Hill, found that the rates of spontaneous mutation in DNA — a key driver of evolution — rise very steeply as temperatures increase.

Conserved regions include the IR1 latency promoter (Wp), and one zone upstream of and two within BWRF1.IR1 is heterogeneous in 70 % of strains, and this heterogeneity arises from sequence exchange between strains as well as spontaneous mutation, with inter-strain recombination more common in tumour - derived viruses.

Mice homozygous for the obese spontaneous mutation, Lepob (commonly referred to as ob or ob / ob), exhibit obesity, hyperphagia, transient hyperglycemia, glucose intolerance, and elevated plasma insulin.

This breed did not originate in Egypt, as one might think, but rather in Canada as a result of a spontaneous mutation, born to a black and white domestic cat.

A spontaneous mutation is an uncommon, although not rare, happening.

It was established that the curly - coat was the result of a spontaneous mutation by a dominant gene.

Folded ears are the result of a spontaneous mutation.

The apparently «normal footed» cats would have been polydactyls with barely discernible extra toes, but whose offspring had more prominent extra toes - giving the appearance of either spontaneous mutation or recessive genes.

Occurred as a spontaneous mutation in Southern California in 1981 when an adopted stray cat named Shulamith gave birth to a litter of kittens in which two of the four had ears that curled away from their faces.

Occurred as a spontaneous mutation in Southern California in 1981 when an adopted stray named Shulamith gave birth to a litter of kittens in which two of the four had ears that curled away from their faces.

Began as a spontaneous mutation in a litter of New York farm cats in 1966.

Not exact matches

Brown believes that about half of the inherited cases of ALS may be the result of mutations in the gene, and he suspects that some of the spontaneous cases may also be caused by defects in this gene.

The DDD team focused on spontaneous new mutations that arise as DNA is passed on from parents to children.

While adamantane resistance mutations appeared readily, it took 15 - 38 years after FDA approval to emerge, but emerged 3 times, whereas, the less spontaneous oseltamivir mutations took at most 7 years, serving as a public health cautionary tail.

People with autism carry an average of 74 spontaneous, or de novo, mutations, the researchers found.

Sebat and colleagues discovered that spontaneous structural mutations occurred at a surprisingly high rate in individuals — 20 percent — and mutations in autism tended to disrupt genes.

The new study by Iossifov et al conservatively estimates that 30 % of all cases of autism spectrum disorder (ASD) are caused by de novo, or «spontaneous» mutations — DNA mutations appearing in a child that neither parent has.

About the same time, scientists at Cold Spring Harbor Laboratory in Long Island, N.Y., focusing on families with one autistic child, reported that an estimated 10 to 30 percent of all reported cases of autism may be caused by new (or spontaneous) mutations in the number of copies of genes in children (that were not found in either parent).

A range of mutations — common, rare, inherited and spontaneous — in more than 70 different genes are now linked to the disorder

«Genetic analysis supports prediction that spontaneous rare mutations cause half of autism: Quantitative study identifies 239 genes whose «vulnerability» to devastating de novo mutation makes them priority research targets.»

A sample composed only of «simplex» families makes possible a much more accurate comparison of the relative frequency of spontaneous and inherited causal mutations.

Numerous spontaneous and induced mutations that affect cerebellar neurogenesis are providing precious information on the molecular mechanisms that regulate mammalian neural development at large.

To correct RPE65 mutation damage, scientists are evaluating drugs, cell transplants and gene delivery in Rpe65 knockout, transgenic and spontaneous mutant mice, and spontaneous Rpe65 - mutant dogs.

But other scientists cautioned that other explanations beside spontaneous genetic mutation could also account for the study's results.For example, said Dr. Ann Pulver, director of the epidemiology and genetics program in psychiatry at Johns Hopkins University, «It may be that the fathers of schizophrenics have unusual characteristics that delay reproduction.»

The above may be expressed as dominant, recessive, or X-linked disorders or they may be the result of spontaneous de novo mutations, while many forms present with variable phenotypic expression and are more difficult to diagnose compared to lethal forms.

Mignot and his colleagues identified a spontaneous genetic mutation in those animals that incapacitated a receptor in brain cells for hypocretin.

The improvement of visual acuity in sham - treated eyes was unexpected based on the natural history of LHON, for which partial spontaneous recovery is reported in only 8 to 22 % of patients with the G11778 ND4 mutation (Lam et al. 2014, Riordan - Eva et al. 1995).

A spontaneous tRNA suppressor of a mutation in the Chlamydomonas reinhardtii nuclear MCD1 gene required for stability of the chloroplast petD mRNA

We use this in vitro model of spontaneous tumorigenesis to generate a library of cell lines with 25 different de novo JAK1 - activating mutations, 6 of which are targeting two residues, Phe958 and Pro960, located in the hinge region at the periphery of the ATP - binding pocket.

Design and Methods Taking advantage of a model of spontaneous cellular transformation, we sequenced JAK1 in selected tumorigenic BaF3 clones and identified 25 de novo JAK1 activating mutations, including 5 mutations already described in human leukemias.

Independent, spontaneous mutants of adenovirus type 2 - simian virus 40 hybrid Ad2 + ND3 that grow efficiently in monkey cells possess indentical mutations in the adenovirus type 2 DNA - binding protein gene

The transgenic «knock - in» mouse strain of the NaV - channel SCN9a loci (K1449V and L858F mutations) show the expected phenotype of spontaneous pain related behaviour.

Wigler's own investigation, published in 2007, first showed these results — that people with autism had more spontaneous CNV mutations than were found in the general population.

Kirlee, as a supposed distantly related cat with the same spontaneous genetic mutation, would be a good outcross.