Sentences with phrase «stage disease as»

«Although there is a high risk of progression to decompensated cirrhosis and liver cancer among patients with advanced fibrosis, limiting access to people who have already progressed to late - stage disease as compared to treating earlier to prevent these liver - related complications seems counter-intuitive as a public health strategy.»

Not exact matches

Darzalex, however, has not yet reached its peak potential as the drug moves into earlier stages of the disease and is being tested on solid tumours like lung cancer.

But older people who develop Alzheimer's disease often first enter a stage known as mild cognitive impairment, which involves more serious problems with memory, language, thinking, and judgment.

At the Challenge Festival, startups like as BaseTrace, which «uses DNA - based tracers to track where industrial fluids are going in large, complex environments» and Reliefwatch, a cloud - based system that uses smartphone technology to track inventory and diseases for healthcare organizations in the developing world, battled it out on stage for a grand prize of $ 150,000 in investment.

Brain cancer has taken center stage recently as several high profile individuals announced they are fighting the disease.

It has been said that «suicide is a permanent solution to a temporary problem»; but not all problems feel temporary and not all problems are temporary — the suffering, psychological as well as physical, in many end stage diseases comes to mind.

They raise the question of whether aging is best understood as a natural, permanent stage of life or a disease.

The Human Genome Project, not long ago completed at a cost of $ 3 billion, was often presented by its promoters as opening the way to discovering the ultimate genetic causes of all diseases, thus setting the stage for their cure.

Radiologists came from across the hospital to peer at the results, disbelieving: A perfectly healthy 21 - year - old nonsmoker with no family history of the disease had lung cancer, which three days later would be diagnosed as stage IV, the most advanced form.

As defined by Custer in the early 1970s, the disease has three stages.

Studying itching sensations is a relatively new field, but if we look at the number of diseases where itch is a major symptom, it includes not only atopic dermatitis but also nervous system disorders such as multiple sclerosis, as well as infection and end stage kidney disease.

Researchers performed liquid biopsies: A small amount of intraocular fluid was extracted from eight eyes of members of the same family at various stages of NIV and, as a control, four eyes with a noninflammatory eye disease.

Currently around 20 % of people are diagnosed with bowel cancer as an emergency when outcomes are generally poorer and almost 50 % in later stages of the disease when it is harder to treat.

They isolated blood cells from HIV - positive patients on antiretroviral therapy and at different stages of disease progression, as well as cells from non-infected individuals.

As rates of skin cancer, or melanoma, rise for men and women in the United States, health experts are debating the effectiveness of annual total body examinations in helping to detect the disease in its earlier stages.

The biological molecules increase the sensitivity of the material, meaning it can sense extremely low concentrations of substances, such as antibodies, and thus potentially detect diseases in their earliest stages.

«Despite the progress and the success of viral eradication, numerous questions remain unanswered such as response based on race, still difficult - to - treat situations such as patients with end - stage liver disease or undergoing hemodialysis, access to and affordability of these therapies, improvement in quality of life, and cost - effectiveness.

«Based on the results of this study, the side of origin of CC [colon cancer](left vs. right) should be acknowledged as a criterion for establishing prognosis in both earlier and advanced stages of disease.

As well as revealing step by step how disease and infection can aggravate and accelerate the early stages of Alzheimer's, Perry and his colleague Clive Holmes have begun a pioneering trial in 40 people to see if a drug that acts to dampen inflammation in the body can help delay the progress of the brain diseasAs well as revealing step by step how disease and infection can aggravate and accelerate the early stages of Alzheimer's, Perry and his colleague Clive Holmes have begun a pioneering trial in 40 people to see if a drug that acts to dampen inflammation in the body can help delay the progress of the brain diseasas revealing step by step how disease and infection can aggravate and accelerate the early stages of Alzheimer's, Perry and his colleague Clive Holmes have begun a pioneering trial in 40 people to see if a drug that acts to dampen inflammation in the body can help delay the progress of the brain disease.

Although tau imaging is still in its earliest stages, Ryan hopes that such imaging will accelerate drug development and that finding a blood - based biomarker for Alzheimer's to reveal risk (much like cholesterol serves as a marker for cardiovascular risk) will change the field dramatically in terms of how doctors can diagnose the disease.

The Duke medical researchers and ecologists who have joined that project hope to identify which species flourish in early stages of the human microbiome, how they are influenced by the consumption of breast milk, and what role they play in critical diseases affecting infants as well as in chronic diseases that occur later in life.

These tangle - like structures appear at early stages of Alzheimer's and are not found in other neurodegenerative diseases such as Parkinson's disease.

Once stem cells can be grown and differentiated in a controlled way to replace degenerated cells and repair tissues, medical science may then be able to diagnose and cure many intractable diseases at their earliest stages, such as type 1 diabetes, Parkinson's disease, various cardiovascular diseases, liver disease, and cancer.

«Our findings show that a specific genetic marker (known as allele * 2 of the HS1, 2 A enhancer region) influences not just disease activity in RA patients, but also response to therapy in the early stages of their disease,» said lead investigator Dr Gabriele Di Sante of the Institute of Rheumatology and Related Sciences, Catholic University of the Sacred Heart, Rome, Italy.

That would open the door to spotting proteins associated with diseases such as cancer when those ailments are still in their formative, treatable stages.

An unexpected finding was that many of the innate immunity pathways that were active in the late stages of these inherited blinding diseases were the same as those that are associated with more common vision disorders including diabetic retinopathy and age - related macular degeneration, or AMD.

So now, with late - stage clinical failures piling up, the U.S. Food and Drug Administration (FDA) has set off down a path to adapt those standards as researchers are pushed inexorably into earlier and earlier forms of the disease, ahead of the brain damage inflicted by Alzheimer's.

Vtesse is currently running a late - stage clinical trial of the drug, a large sugar molecule known as a cyclodextrin, in which it is injected by lumbar puncture into the spinal fluid of children with the disease (see «Why are people fighting over a promising treatment for a fatal childhood disease»).

And we may wonder: Are these memory lapses a normal part of aging, or do they signal the early stages of a severe disorder such as Alzheimer's disease?

«However, these pharmacological and surgical treatments address the patient's symptoms, such as to improve mobility functions in the early stages of the disease, but the treatments can not slow down or stop the disease process,» Prof Kim explains.

This results in as many as 16 patient groups for this benefit assessment, which mainly differ in type of virus, pretreatment and stage of disease.

«The ability of MMV048 to block all life cycle stages of the malaria parasite, offer protection against infection as well as potentially block transmission of the parasite from person to person suggests that this compound could contribute to the eradication of malaria, a disease that claims the lives of several hundred thousand people every year,» said Professor Chibale, Founder and Director of H3D, founding Director of the South African Medical Research Council (SAMRC) Drug Discovery Research Unit at UCT, and senior author of the paper.

With the management of type 2 diabetes and its risk factors (such as obesity and physical inactivity) being simpler and cheaper than treating complications of later stage disease, the researchers note that prevention of disease onset and complications will be crucial to improve health and avoid further economic burden.

«The best way to apply immunotherapy as cancer prevention is during tumor dormancy to prevent advanced stage disease.»

Researchers and doctors are excited about the discovery, as there are no oral therapies approved in Canada for use at this very early stage of the disease.

However, in the early stages of disease these «biomarkers» can be difficult to detect, as they are relatively rare.

Professor Fallon said: «This identification of an early stage cellular checkpoint that can act as a break on allergic responses has important implications for the development of new therapeutic approaches for asthma and other allergic diseases.»

An increase in serum phosphorus levels in African Americans with chronic kidney disease (CKD) is associated with faster progression to kidney failure, known as end - stage renal disease (ESRD), according to new research presented at ASN Kidney Week 2015 November 3 - 8 in San Diego, CA.

He describes his results as a small step down the road to treatments for genetic diseases and insists that ethical objections are ridiculous at such an early stage.

This results in as many as ten patient groups for this benefit assessment, which mainly differ in type of virus, pretreatment and stage of disease.

Regardless of disease stage, patients who received surgery lived an average of 57 months, compared to less than 12 months for patients who received only non-surgical treatment (such as chemotherapy or radiation therapy), and 1.4 months for patients who received no treatment at all.

They hope that these achievements might also serve as a model for improving the management of other disease stages and settings.

«As treatments for the earliest stages of AMD are developed in the coming years, correct identification of AMD in primary eye care will be critical for routing patients to treatment as soon as possible so that the disease can be treated in its earliest phases and central vision loss avoided.&raquAs treatments for the earliest stages of AMD are developed in the coming years, correct identification of AMD in primary eye care will be critical for routing patients to treatment as soon as possible so that the disease can be treated in its earliest phases and central vision loss avoided.&raquas soon as possible so that the disease can be treated in its earliest phases and central vision loss avoided.&raquas possible so that the disease can be treated in its earliest phases and central vision loss avoided.»

Most excitingly, by comparing between individual cells, the team expect to reveal differences which could play key roles in both the early stages of life and the first stages of diseases such as cancer.

A multivariable analysis that included factors such as age, sex, stage, disease burden, certain mutations and prior treatment showed that obesity still improved PFS and OS compared to normal BMI patients.

According to Halassa, the new research sets the stage for ever more detailed studies on the complex behavior involved in how the mammalian brain pays attention to what's important, and especially how those neural circuits are broken in cases of attention - deficit diseases, such as ADHD, autism, and schizophrenia.

That has not only caused large pharma companies to back away from early - stage drug discovery, but it has forced them to pursue primarily large - market blockbuster drugs for common conditions such as heart disease and cancer, while avoiding medicines for rare diseases.

It could also help set the stage for heart disease, as well as other problems, such as diabetes or depression.

Factors such as gender, smoking, asbestos exposure and disease stage did not have an effect on whether patient's disease was positive for PD - L1 expression, but researchers did find that expression of the protein was more common in non-epithelial tumours compared to epithelial tumours.

«Cutting sodium can cause other physiological changes such as increased resistance to insulin, which can set the stage for diabetes and increase the risk of death from heart disease,» Stolarz - Skrzypek says.