Sentences with phrase «stage safety trial»

Not exact matches

If animal tests go well, the next trials will be with humans, a process that involves three stages — one for safety, the next to see if the protein kills cancer in a limited number of people, and the last to turn it loose in a large group.

«The promising safety results of these early trials set the stage for additional HCQ trials in different cancers, and trials involving new autophagy inhibitors that are being developed by pharmaceutical companies,» said Amaravadi.

The safety study sets the stage for phase II clinical trials looking at whether high dose vitamin C is effective at extending overall lifespan and quality of life for patients undergoing radiation and chemotherapy.

The first stage of the Bangkok trial will confirm the vaccine's safety, while gauging protection will begin in a year.

One of the major parameters was the safety of these agents in the respiratory airways and lung parenchyma, since several of these agents are known to cause adverse effects.23 The main adverse effects observed were cough, transient fever and transient decrease in the respiratory functions after the aerosol administration.8, 19, 20 Moreover; it has been observed that excessive deposition of these agents in one site of the respiratory system can induce non-specific side effects in the form of pulmonary edema as observed with many other drugs.16 These side effects were milder when a premedication with bronchodilators and inhaled corticosteroids were administered.8, 19, 20 Until now no long term trial (> 9 months) has been performed since all patients included in previous studies had stage IV non-small cell lung cancer (NSCLC).

The shorter - term single - dose trial is recruiting 40 healthy and relatively young (ages 21 - 65 y) subjects for a narrow safety trial, whereas the multiple - dose trial will be conducted in 60 persons suffering with PD (the trial protocol specifies the recruitment of idiopathic PD subjects), and includes subjects that are somewhat older (ages 40 - 80) and with a wider range of severity of disease (Hoehn and Yahr stages I - III) than were used in AFFiRiS» trial of PD01A.

The huntingtin lowering ASO trial is still in early safety stages, but the approach has shown promise so far.

The next stage of the trials will increase the volume of patients and asses the long - term safety of the treatment.

Primary analysis of a phase 1b multicenter trial to evaluate safety and efficacy of talimogene laherparepvec (T - VEC) and ipilimumab (ipi) in previously untreated, unresected stage IIIB - IV melanoma.

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The community had expected that youth issues, gang violence and safety would be addressed and resolved at an early stage of the trial.