Sentences with phrase «stage trial as»

In February alone, Lundbeck discontinued two of its trials, Merck discontinued one of its studies, and Accera failed a late - stage trial as well.

Not exact matches

The new Alzheimer's framework may not be much of a surprise given numerous, high - profile, late - stage clinical trial failures in the field by companies like Eli Lilly and Merck, and the decision by other companies (such as Pfizer) to back away from the risk - prone field.

The Simpson trial set the stage for the Casey Anthony trial, the Oscar Pistorius trial, and any other recent case that played out in public (and on television) almost as much as it played out in the courtroom.

Long before the Hogan trial took center stage, Gawker Media invested millions (Denton won't say how much exactly) in building a commenting and reader - blogging system it called Kinja, which Denton described as nothing less than an attempt to turn the publishing world on its head — to put readers on the same level with journalists and publishers.

Heart rate was recorded 2 minutes into each stage and was continuously monitored throughout the trial using a Polar RS300x heart rate monitor (Polar Electro Oy, Kempele, Finland) to capture maximum heart rate, which was used as a marker of appropriate effort.

Labour backbencher Jess Phillips will take to the West End stage later this month, as Hamlet is put on trial for stabbing Polonius through the arras.

Olujimi also asked the court to issue a stern warning to the prosecution to be serious in the trial and to ensure that Dasuki is produced in court at all stages of the trial as demanded by law.

Much of my team's work focuses on transgene technology from early - stage experiments in model plants all the way to field trials with crop plants such as corn.

As well as revealing step by step how disease and infection can aggravate and accelerate the early stages of Alzheimer's, Perry and his colleague Clive Holmes have begun a pioneering trial in 40 people to see if a drug that acts to dampen inflammation in the body can help delay the progress of the brain diseasAs well as revealing step by step how disease and infection can aggravate and accelerate the early stages of Alzheimer's, Perry and his colleague Clive Holmes have begun a pioneering trial in 40 people to see if a drug that acts to dampen inflammation in the body can help delay the progress of the brain diseasas revealing step by step how disease and infection can aggravate and accelerate the early stages of Alzheimer's, Perry and his colleague Clive Holmes have begun a pioneering trial in 40 people to see if a drug that acts to dampen inflammation in the body can help delay the progress of the brain disease.

As Scientific American reported earlier this year, more than half of the current cancer clinical trials do incorporate some form of immunotherapy but still oncologists are often only in the early stages of understanding how to use such treatment on a larger scale.

But highly trained life scientists will still be needed for such tasks as late - stage development (ensuring smooth implementation of final phase (III and IV) clinical trials) as well as compliance with regulatory demands (so - called commissioning and validation specialists), according to Croonen.

HB 661 would permit people with chronic illness to get therapies in early - stage clinical trials — not just terminally ill patients, as the state's current «right - to - try» law does.

Ipilimumab as adjuvant therapy significantly improves overall survival in patients with high risk stage III melanoma, according to the EORTC 18071 phase III trial results presented for the first time at the ESMO 2016 Congress in Copenhagen.

The EORTC 18071 phase III trial evaluated ipilimumab as adjuvant therapy for patients with high risk stage III melanoma.

Vtesse is currently running a late - stage clinical trial of the drug, a large sugar molecule known as a cyclodextrin, in which it is injected by lumbar puncture into the spinal fluid of children with the disease (see «Why are people fighting over a promising treatment for a fatal childhood disease»).

The next stage will be a full clinical trial to test the effectiveness of ebselen as a treatment.

Innovative clinical trial approaches that have proven successful in other disease areas such as oncology (e.g., platform trials, umbrella and basket designs) might be employed with stratification of subjects by AT (N) profile, enabling a data - driven approach to identify the biological stage of disease in which an intervention has maximal treatment effects.

ARandomized, Phase III, Double - Blind Placebo - Controlled Trial of Sunitinib as Maintenance Therapy in Non-Progressing Patients following an Initial Four Cycles of Platinum - Based Combination Chemotherapy in Advanced, Stage IIIB / IV Non-Small Cell Lung Cancer

For more information regarding Bristol - Myers Squibb Clinical Trial participation, please visit www.BMSStudyConnect.com Inclusion Criteria: • Early stage IB - IIIA, operable non-small cell lung cancer, confirmed in tissue • Lung function capacity capable of tolerating the proposed lung surgery • Eastern Cooperative Oncology Group (ECOG) Performance Status of 0 - 1 • Available tissue of primary lung tumor Exclusion Criteria: • Presence of locally advanced, inoperable or metastatic disease • Participants with active, known or suspected autoimmune disease • Prior treatment with any drug that targets T cell co-stimulations pathways (such as checkpoint inhibitors) Other protocol defined inclusion / exclusion criteria could apply

Currently, lymphadenectomy is an eligibility requirement for cutting - edge adjuvant therapy trials such as Southwest Oncology Group (SWOG) 1404 (ClinicalTrials.gov identifier: NCT02506153), which randomizes stage III melanoma patients to an anti — programmed death 1 antibody or standard - of - care adjuvant therapy (high - dose interferon or high - dose ipilimumab).

One of the major parameters was the safety of these agents in the respiratory airways and lung parenchyma, since several of these agents are known to cause adverse effects.23 The main adverse effects observed were cough, transient fever and transient decrease in the respiratory functions after the aerosol administration.8, 19, 20 Moreover; it has been observed that excessive deposition of these agents in one site of the respiratory system can induce non-specific side effects in the form of pulmonary edema as observed with many other drugs.16 These side effects were milder when a premedication with bronchodilators and inhaled corticosteroids were administered.8, 19, 20 Until now no long term trial (> 9 months) has been performed since all patients included in previous studies had stage IV non-small cell lung cancer (NSCLC).

Although some anti-amyloid drugs are currently in late - stage clinical testing, several trials have also failed and there is much debate as whether this is a suitable approach for a new treatment.

Table 1: Selection, Design & Construction of HSV - based Oncolytic Viruses Table 2: Selection, Design & Construction of Adenovirus - based Oncolytic Viruses Table 3: Selection, Design & Construction of Vaccinia Virus - based Oncolytic Viruses Table 4: Selection, Design & Construction of Vesicular Stomatitis Virus - based Oncolytic Viruses Table 5: Selection, Design & Construction of Newcastle Disease Virus - based Oncolytic Viruses Table 6: Selection, Design & Construction of Various Virus - based Oncolytic Viruses Table 7: Current Company - Sponsored Clinical Trials of T - Vec Table 8: Clinical Trials of ColoAd1 Table 9: Clinical Trials with JX - 594 Table 10: Clinical Trials with GL - ONC1 Table 11: Clinical Trials of CAVATAK (CVA21) Table 12: Clinical Trials with MV - NIS Table 13: Overview of Oncolytic Viruses by Development Phase & Virus Family Table 14: Profile of Approved and Marketed Oncolytic Viruses Table 15: Pivotal Study Design of Oncolytic Viruses in Late Stage Development Based on Previous Clinical Results Table 16: Approved Indications of Immune Checkpoint Inhibitors Table 17: Active Clinical Studies of Oncolytic Viruses in Combination with Immune Checkpoint Inhibitors (ICI) Table 18: Planned Clinical Studies of Oncolytic Viruses in Combination with Immune Checkpoint Inhibitors (ICI) Table 19: Active or Planned Clinical Studies of Oncolytic Viruses in Combination with Other Anti-Cancer Therapeutics Table 20: Pattern of Transgenes in Oncolytic Viruses in Relation to Development Phase Tables 21a and 21b: Indications and Frquency and Way of Administration of Oncolytic Viruses in Active and / or Positive Completed Clinical Studies Table 22: Small and Medium Pharma & Biotech as Partner for Regional Co-Development of Oncolytic Viruses Table 23: Immuno - Oncology Portfolio of Major Pharma & Biotech with Interest in Oncolytic Viruses Table 24: Interests of Major Pharma & Biotech in Oncolytic Viruses Table 25: First Generation Oncology Virus Companies and their Sources of Technology Table 26: Second Generation Oncology Virus Companies and their Sources of Technology Table 27: Third Generation Oncology Virus Companies and their Sources of Technology Table 28: Fourth Generation Oncology Virus Companies and their Sources of Technology Table 29: Grants, Credits & Donations Table 30: Financing by Venture Capital, Private Equity and Other Private Placements Table 31: Collaboration & Licensing Agreements Table 32: Companies Listed on Stock Exchange & Offerings Table 33: Mergers & Acquisitions

The success of this first trial sets the stage for a larger study in hundreds of HD patients, as soon as possible.

In 2005, Dan co-founded and served as President and CEO of Inviragen Inc., which he transformed from a virtual start - up to a global clinical stage company with sites in Colorado, Wisconsin and Singapore and translated two vaccines from the research bench to human clinical trials, including one for dengue fever.

These mutant kinases are attractive therapeutic targets, as demonstrated by the efficacy of imatinib in BCR - ABL — positive chronic myelogenous leukemia (CML), 5 as well as in MPD associated with activating alleles involving PDGFRA or PDGFRB.2, 6,7 In addition, activating mutations in the FLT3 receptor tyrosine kinase are the most common genetic event in acute myeloid leukemia (AML), and specific inhibitors of the FMS - like tyrosine kinase 3 (FLT3) have entered late - stage clinical trials.8 Although mutations in tyrosine kinases and in other genes have been identified in a subset of MPD and AML, in many cases the genetic events that contribute to the molecular pathogenesis of these diseases remain unknown.

As part of the NCTN, the Kimmel Cancer Center partners on government - funded clinical trials in more advanced stages of development.

Most recently, CRI has launched a new «venture philanthropy» program called the Cancer Vaccine Acceleration Fund (CVAF) as a means to catalyze development of next - generation therapeutic cancer vaccines and other immunotherapies by helping to address the critical shortage of capital available for early stage clinical trials.

As blogger T.J. Sharpe — who, after a stage 4 melanoma diagnosis, has been thriving for three years in a trial of the immunotherapy drug Keytruda — puts it, «The truth is the drug isn't beating cancer; my immune system is.»

People in the early stages of dementia may be able to enroll in clinical trials, as well, to gain access to experimental new treatments.

Grape skin and grape seed extracts have been shown to reverse the signs of aging and also to improve brain functions enough to advance resveratrol into the final stages of clinical trials as an Alzheimer drug candidate.

With my first pregnancy I had my ups and downs with food, fitness and overall emotional and hormonal imbalances but through trial and error as well as my education I managed to find the right tools for each stage of my pre and post pregnancy time and I would like to share them with you.

Dating is a stage of romantic relationships in humans whereby two people meet socially with the aim of each assessing the other's suitability as a Best Dating Chat lines with Exclusive Free Trials Just for You - Top 10 Dating Chatlines!

2018-04-08 16:41 Dating is a stage of romantic relationships in humans whereby two people meet socially with the aim of each assessing the other's suitability as a Rodney Alcala, who used footage of his 1978 appearance on The Dating Game to defend himself at trial, is found guilty of murdering four women and a girl

Dating is a stage of romantic relationships in humans whereby two people meet socially with the aim of each assessing the other's suitability as a Rodney Alcala, who used footage of his 1978 appearance on The Dating Game to defend himself at trial, is found guilty of murdering four women and a girl

As Dunham explains in the opening moments, this series aims to show his friends (all of them hand - controlled dummies he voices) out in the world, instead of letting them do their usual on - stage telling of their trials.

BULL Picked up to series STUDIO: CBS TV Studios / Amblin Television / Stage 29 Productions TEAM: Paul Attanasio (w, ep), Dr. Phillip C. McGraw (w, ep), Steven Spielberg (ep), Justin Falvey (ep), Darryl Frank (ep) Jay McGraw (ep), Rodrigo Garcia (d, ep) LOGLINE: Inspired by the early career of Dr. Phil McGraw as the founder of one of the most prolific trial consulting firms of all time.

The stage was set with the two public education luminaries, ready to square off on such lightning rod issues as tenure and teacher dismissal laws in the wake of last month's Vergara trial: Randi Weingarten, leader of the nation's second largest teachers organization, AFT, and Superintendent John Deasy, leader of the second largest school district in the...

As an intern, you will assist trial attorneys in enforcement matters, from the initial stage of receiving and evaluating passenger complaints, through a potential investigation.

The BlackBerry messenger music application was first unveiled in August as a closed beta, which has now moved out of the trial stage for to download and use.

This statement is based on feeding trial and nutrient content of the product and it ensures that the product is formulated to provide for the basic nutritional needs of the life stage for which it is intended — such as for puppies, adult dogs or senior dogs.

In fact, we are the 1st and only raw diet to be scientifically substantiated as complete and balanced for all life stages through AAFCO Protocol Feeding Trials.

This procedure is still considered to be in the «clinical trial» stage, subject to modification as more long term results become known.

AAFCO developed a protocol for a six - month feeding trial that can be used as a tool to determine whether a food can sustain life in a target test population (dogs or cats in all life stages, or specific stages of growth of maintenance).

On top of the regular stages of that there's also ten different trials specific to each Master which tasks you with pulling off tricky shots, often revolving around their special abilities, providing a good chance to hone your skills as well.

As you progress through the game, stages introduce new obstacles, enemies, and time trial challenges that help keep the journey fresh and exciting.

So although it may not be the biggest and best form of dlc we've seen incorporated into the series and its spin - offs, it's not that far behind the Den of Trials, as it too is a new area containing a special treasure for those who best all 40 rooms, which is exactly the same number of stages the Den of Trials contains.

The problem is that there's usually a single solution to the puzzle - like stages and it's simply not fun to have to replay a battle several times as you are faced with some inevitable trial - and - error games that end in error.

As you complete each level, you will unlock a time trial mode for each of the 11 stages.

In addition to spot - on recreations of the first six games in the series, the Mega Man Legacy Collection includes a totally rad «Museum,» full of concept art, old advertisements, enemy stats, and entire soundtracks for each game, as well as an addicting «Challenge Mode,» which remixes elements of various levels from throughout the six included games into custom time trial stages.