Sentences with phrase «stage trial for»
The latest failure came in September, when Axovant said it failed a key late - stage trial for its drug, intepirdine.
http://www.businessinsider.com/ Not exact matches
While the new mid-stage study results from DNDi were impressive (they showed cure rates of 96 % to 97 % even for the sickest patients and those with liver scarring), more late - stage trials will be necessary before the drug is available on a large scale in the developing world.
But he stopped short of declaring the song in the public domain, leaving open the possibility that others may hold the copyright and setting the stage for a trial.
Solanezumab's inability to best placebo in a late - stage trial, combined with impending patent expirations for big sellers like the erectile dysfunction drug Cialis and ADHD medication Strattera, are largely driving the cuts.
Intarcia has completed several late - stage clinical trials in which it uses the pump to deliver a glucose - controlling drug continuously for months — an idea, that if successful (and approved by the FDA) could significantly help patients with type 2 diabetes, fewer than half of whom maintain the recommended glycemic levels.
But a late - stage clinical trial called CheckMate - 026 for the drug failed to meet its primary goal of halting cancer progression in advanced, untreated patients whose tumors consisted of at least 5 % PD - L1.
The biotech plans to shed 20 % of its nearly 600 employees in order to secure yearly cost - savings of about $ 21 million — money which can then be used to double down on late - stage clinical trials for its experimental Parkinson's drug.
The FDA actually approached Mitsubishi Tanabe and asked the firm to submit the drug for approval after it showed promise in a late - stage trial in Japan.
If you're suffering from advanced stages of cancer the best news your oncologist can deliver, apart from saying you're winning the battle, is that you're eligible for a promising new drug trial.
Apps that are for demo, trial or test purposes or are in the beta stage do not get accepted by Apple.
Unfortunately for the firm, this enrollment halt may also implicate a future failure in a later - stage trial of the drug, PEGPH20.
In a late - stage trial, Darzalex combined with Velcade and chemotherapy slashed patients» risk of worsening disease or death by a stunning 61 % compared with the results for Velcade and chemotherapy alone.
The first stage of trials will be carried out on test tracks, and will try and iron out details like how close the trucks should be and what roads will be suitable, the Department for Transport said in a press release.
The Simpson trial set the stage for the Casey Anthony trial, the Oscar Pistorius trial, and any other recent case that played out in public (and on television) almost as much as it played out in the courtroom.
In May, Kite disclosed that one person had died in a clinical trial for its late - stage CAR - T therapy from cerebral edema, a condition in which excessive fluid causes the brain to swell.
Although Anavex Life Sciences» Alzheimer's disease program should offer up plenty of data to digest this year, its research program is very early stage, and the company's balance sheet is worrisome enough for me to avoid it until placebo - controlled trial results are available.
Most biotechs would have shuttered a clinical program that showed absolutely no efficacy whatsoever in a late - stage trial, but Novavax has instead doubled down on RSV by going forth with its phase 3 trial of the RSV F vaccine for infants via maternal immunization, and begun planning for another trial in older adults that's reportedly on track to kick off in 2018.
The Biblical accounts of God - to - human relationship and affairs going from the very obvious to the very mysterious, starting with creation and going through a multitude of stages, the fall, the expulsion and curse, trials and covenants, rebellion and Law, culminating with God's «Ultimate Provision» for Salvation, the «Good News» of the Lord Jesus Christ, His only begotten Son, the «New Covenant,» the «Millennial Kingdom» to come, the end of time, and the afterlife, are the basis for the Christian Theology on «Time Dispensations.»
If, for example, the initial exercise work rate is excessively high, it will produce physiological changes that result in the conscious RPE being greater than that which the central controller considers optimal for a particular stage during an exercise trial.
Future trials in this area would benefit from drawing on a framework for trials of complex interventions which explicitly requires theoretical modelling between processes and outcomes in the pre-trial stage, and a process evaluation of the trial (Anderson 2008).
Labour backbencher Jess Phillips will take to the West End stage later this month, as Hamlet is put on trial for stabbing Polonius through the arras.
He claimed that the situation could be responsible for the loss of several high profile cases being handled by the commission after «unfairly staged managed media trials» with the attendant pain and embarrassment to the victims.
The Attorney General (AG) filed a nolle prosequi in the case of the two, which had reached the stage where a jury was to be constituted for the trial of Daniel Asiedu and Vincent Bosso.
The senator had staged a break - out from the police vehicle conveying him to face trial for criminal conspiracy and possession of illegal arms in Lokoja.
Among other benefits for the district attorney offices across the city, the funding will provide Bronx County with a vertical integration system which proposes delegating every stage of the prosecution to a single assistant district attorney in order to eliminate delays and backlogs in trial cases, a Rikers Island prosecution bureau and a Conviction Integrity Unit to review past convictions and ensure the fairness of tried cases.
However, Caproni said she wouldn't allow the last piece introduced into evidence, and admonished the defense for bringing the issue up at such a late stage in the trial.
While she alluded to the speedy - trial issue in an interview with the Troy Record, for now, Donnelly seems somewhat loath to critique her prospective opponent in detail, at least at this early stage of the campaign.
If it were not for the small matter of a global financial crisis or the vital debate over what Peter Mandelson did or did not say over the hummus to George Osborne, all eyes would now be on the next stage of the debate about extending detention without trial.
AAV is in use in many late - stage clinical trials in the United States, and has already been approved for use in one gene therapy drug in the European Union.
AveXis, Inc., a clinical - stage gene therapy company developing treatments for patients suffering from rare and life - threatening neurological genetic diseases, announced in July 2016 that the U.S. Food and Drug Administration (FDA) granted Breakthrough Therapy Designation for the treatment based on preliminary clinical results from the trial of AVXS - 101.
The phase III CONVERT trial enrolled 547 patients with limited - stage SCLC for concurrent chemo - radiotherapy who were randomised to once - daily or twice - daily radiotherapy.
The first stage of clinical trials for at least one potential vaccine candidate is slated to begin in September, according to Fauci.
If the NIH inoculation proves safe, it will then move to the next stage of trials in the Caribbean and South America — if the months - old budget request for emergency Zika funding clears Congress, he says.
In rodents, repeated messenger RNA treatment produces no dangerous side effects, setting stage for clinical trial
But highly trained life scientists will still be needed for such tasks as late - stage development (ensuring smooth implementation of final phase (III and IV) clinical trials) as well as compliance with regulatory demands (so - called commissioning and validation specialists), according to Croonen.
For example, Matt Krause, director of human resources at CV Therapeutics, says, «Our research programs include multiple, cutting - edge cardiovascular product candidates in various stages of clinical trials and preclinical programs, all of which rely heavily on the contributions from our many B.S. - and M.S. - level scientists.»
Several years ago, for example, poor chemical probe data led researchers to pursue a final stage clinical trial on a cancer drug candidate called iniparib.
Ipilimumab as adjuvant therapy significantly improves overall survival in patients with high risk stage III melanoma, according to the EORTC 18071 phase III trial results presented for the first time at the ESMO 2016 Congress in Copenhagen.
The EORTC 18071 phase III trial evaluated ipilimumab as adjuvant therapy for patients with high risk stage III melanoma.
During a 24 - month clinical trial, Colby (and fellow ophthalmologists David Chang of the University of California, San Francisco, Doyle Stulting of Emory University's Eye Center in Atlanta, and Stephen S. Lane of Associated Eye Care in Stillwater, Minn.) developed and tested a preferred technique for implanting the device to most effectively treat bilateral end - stage macular degeneration, which most commonly afflicts people over the age of 55.
If animal tests go well, the next trials will be with humans, a process that involves three stages — one for safety, the next to see if the protein kills cancer in a limited number of people, and the last to turn it loose in a large group.
Vtesse is currently running a late - stage clinical trial of the drug, a large sugar molecule known as a cyclodextrin, in which it is injected by lumbar puncture into the spinal fluid of children with the disease (see «Why are people fighting over a promising treatment for a fatal childhood disease»).
Dr. Sparano continued: «This is the first prospectively conducted clinical trial evaluating this assay — or any multigene expression assay for that matter — in which patients with early stage breast cancer were uniformly treated based on their assay results.
«The promising safety results of these early trials set the stage for additional HCQ trials in different cancers, and trials involving new autophagy inhibitors that are being developed by pharmaceutical companies,» said Amaravadi.
Initial results were announced from the Trial Assigning IndividuaLized Options for Treatment (Rx), or TAILORx, a multi-center prospectively conducted trial of more than 10,000 women with early stage breast cancer sponsored by the National Cancer Institute (NCI), part of the National Institutes of Health, and led by the ECOG - ACRIN Cancer Research Group (ECOG - ACRIN) with support from Genomic Health, Trial Assigning IndividuaLized Options for Treatment (Rx), or TAILORx, a multi-center prospectively conducted trial of more than 10,000 women with early stage breast cancer sponsored by the National Cancer Institute (NCI), part of the National Institutes of Health, and led by the ECOG - ACRIN Cancer Research Group (ECOG - ACRIN) with support from Genomic Health, trial of more than 10,000 women with early stage breast cancer sponsored by the National Cancer Institute (NCI), part of the National Institutes of Health, and led by the ECOG - ACRIN Cancer Research Group (ECOG - ACRIN) with support from Genomic Health, Inc..
«First - line immunotherapy treatment can improve survival for subset of lung cancer patients: Results of phase III global clinical trial show that 75 percent of stage IV lung cancer patients with both complex tumor mutations and PDL - 1 positive status respond to nivolumab.»
Later this year early - stage human trials will begin for the drug, a collaboration of CSHL and clinicians at the Monter Cancer Center of North Shore - Long Island Jewish Hospital.
When people with early - stage symptoms took omega - 3 supplements for three months, they had much lower rates of progression than those who did not, according to one small - scale trial.
This study sets the stage for such a trial by identifying which medications should be included.
Conventional drug discovery remains a hit - and - miss affair and Hunter believes the 50 percent failure rates seen for experimental compounds in mid - and late - stage clinical trials due to lack of efficacy is unsustainable, forcing a shift to AI.