Sentences with phrase «stage trials»

On average about 99 % of all drugs in clinical trials never actually make it to approval, and drugs are still failing late - stage trials in 2017.

Some patients have come through early stage trials to be declared effectively cancer free.

Early - stage trials of embryonic - stem - cell therapies for macular degeneration — progressive damage to the retina that causes blindness — are already under way.

The PARP inhibitors have proved disappointing in late stage trials for breast cancer.

If the candidate does not meet these criteria - for example, if it is determined to be ineffective in the target population or if it requires more doses than were predetermined in the TPP - then it will not move forward into later stage trials.

Merck is the latest company to weather bad news in the Alzheimer's drug race, halting a late - stage trial yesterday in an experimental amyloid - targeting candidate called verubecestat after a data monitoring committee said there was «virtually no chance of finding a positive clinical effect,» Reuters reported.

In February alone, Lundbeck discontinued two of its trials, Merck discontinued one of its studies, and Accera failed a late - stage trial as well.

Shares of biotech Halozyme have fallen more than 10 % since Thursday morning as an early - to - mid stage trial for its experimental pancreatic cancer treatment suggested to researchers that it is unlikely to boost survival in patients when added to chemotherapy.

Deutsche Bank analysts said the failure placed up to $ 1 billion in peak sales at risk, though they also said more important would be late - stage trial data, expected after July, about Tecentriq's performance in the larger, more - lucrative lung cancer setting.

The company also tested the virus in a 23 - person, early - stage trial against colorectal, lung, ovarian and skin cancers.

Promising early - stage trial results led to ponatinib's application being fast - tracked, and it was approved in December 2012.

The first results from early - stage trials show that cancer drugs couriered by nanoparticles may reduce the size of tumours in humans.

Juvista is moving into final stage trials in the middle of next year and the drug could be launched by 2011.

This year's 2008 program focused on medical malpractice, where judges observed staged trials, reviewed clinical studies and learned about the differences between «standard of care» and «medical necessity.»

RISQ Group is in advanced stage trials with several other platforms.

AstraZeneca shares soared a whopping 9 % in early Friday trading as the company announced unexpectedly strong results from a late - stage trial of its immunotherapy drug Imfinzi in lung cancer patients.

They are clearly very early stage trials in small numbers of volunteers, but without question we are extremely encouraged by the results»

The latest failure came in September, when Axovant said it failed a key late - stage trial for its drug, intepirdine.

The Chicago team has already formed a company, called Coordination Pharmaceuticals, which has raised seed funds to launch an early stage trial in humans, likely sometime in the second half of this year.

While the new mid-stage study results from DNDi were impressive (they showed cure rates of 96 % to 97 % even for the sickest patients and those with liver scarring), more late - stage trials will be necessary before the drug is available on a large scale in the developing world.

Solanezumab's inability to best placebo in a late - stage trial, combined with impending patent expirations for big sellers like the erectile dysfunction drug Cialis and ADHD medication Strattera, are largely driving the cuts.

To date, no gene therapies have yet been approved in the US, though one to treat another form of LCA has had promising results in late - stage trials.

Still, more drugs are in late - stage trials that could have an impact on the disease, and researchers are pinning hopes on diagnosing the disease early, before symptoms even show up.

The FDA actually approached Mitsubishi Tanabe and asked the firm to submit the drug for approval after it showed promise in a late - stage trial in Japan.

Kyprolis is also being tested in a separate late - stage trial in combination with Celgene's Revlimid and the steroid dexamethasone, or KRd.

Massachusetts - based Alzheon is taking its quest to revive a version of a previously unsuccessful Alzheimer's drug into expensive late - stage trials to the public.

Unfortunately for the firm, this enrollment halt may also implicate a future failure in a later - stage trial of the drug, PEGPH20.

And while early results have been promising, some skeptics have held out on the hype due to concerns over side effects and whether results will persist in later - stage trials.

In a late - stage trial, Darzalex combined with Velcade and chemotherapy slashed patients» risk of worsening disease or death by a stunning 61 % compared with the results for Velcade and chemotherapy alone.

said they will discontinue a late - stage trial of their experimental lung cancer drug after an interim analysis showed it would not meet the main goal of improving overall survival.

The company said a late - stage trial of its cancer drug Abraxane met its main goal of improving the patient's time of survival without worsening skin cancer, when compared to standard chemotherapy.

Another Alzheimer's drug flops late - stage trials.

That would give it a significant head start over its main rival, Clovis Oncology Inc (CLVS.O), whose similar treatment is in late - stage trials.

The late - stage trial was testing Sage's drug, brexanolone, in patients with super-refractory status epilepticus (SRSE) whose seizures persisted despite earlier treatments.

Specifically, Geron and J&J are expected to announce a go / no - go decision regarding the drug's late - stage trial in MDS anytime now.

Most biotechs would have shuttered a clinical program that showed absolutely no efficacy whatsoever in a late - stage trial, but Novavax has instead doubled down on RSV by going forth with its phase 3 trial of the RSV F vaccine for infants via maternal immunization, and begun planning for another trial in older adults that's reportedly on track to kick off in 2018.

The interim military rulers were under severe public pressure to stage the trial, and under a significant degree of international pressure too.

Mesoblast's earlier - stage trials, published in 2015 in Circulation Research, found that patients who received injections of its cell mixture had no further problems related to heart failure.

The woman at the centre of today's news was treated at the Hospital de Egas Moniz in Lisbon, where a team got approval for early - stage trials to explore the potential of nasal cells in treating paralysis.

Gilead recently refused to continue testing its experimental hepatitis C virus drug in combination with one from Bristol - Myers Squibb, a match that resulted in stupendous results in early - stage trials.

Numerous other Alzheimer's drugs have looked promising in early - stage trials, yet ended in failure.

While none of the research efforts is close to clinical use, early stage trials are under way in the United States, England, Israel and Japan.

The first product to market, Exubera by Pfizer, was withdrawn in 2007 because of this and several other companies shutdown their late - stage trials in response.

First, the drug company releases incomplete information about an early - stage trial.

A phase II trial is an intermediate - stage trial that is composed of less than 100 patients.

Short levels of executing a stage Trials - like for time.

But then we're asked to hang in there, for quite a long time, before the inevitable and well - staged trial.