Sentences with phrase «stages of a disease»

Darzalex, however, has not yet reached its peak potential as the drug moves into earlier stages of the disease and is being tested on solid tumours like lung cancer.

Solanezumab, a drug developed by Eli Lilly that also acts on the amyloid hypothesis, failed some key clinical trials, though the company is still testing it in the pre-clinical stages of the disease.

Fernando Pagan, a GUMC associate professor of neurology who directs the Movement Disorders Program at MedStar Georgetown University Hospital, said that to his knowledge, the study «represents the first time a therapy appears to reverse — to a greater or lesser degree depending on stage of disease — cognitive and motor decline in patients with these neurodegenerative disorders.»

The technology measures the stage of disease, rate of progression of disease, drug efficacy, and drug toxicity in several cancers and Alzheimer's disease.

The institute instead ruled that donepezil, rivastigmine and galantamine would only be made available to people at the moderate stage of the disease, saying the medicine did «not make enough of a difference» for some patients.

Comparing a new patient's information with millions of other cases, Patient Rescue might be able to predict that they are in the early stages of a disease that has not yet become symptomatic, for example.

Currently around 20 % of people are diagnosed with bowel cancer as an emergency when outcomes are generally poorer and almost 50 % in later stages of the disease when it is harder to treat.

CAVD progresses rapidly through multiple, distinct stages of disease, but is general diagnosed late, making it challenging to develop targeted treatments.

The team also needs to figure out which types of cancer Th17 cells respond to, and at which stage of the disease.

Patients with severe or terminal stages of disease incurred higher direct costs ($ 54,000).

They isolated blood cells from HIV - positive patients on antiretroviral therapy and at different stages of disease progression, as well as cells from non-infected individuals.

However, even for an expert, it can be difficult to tell how severe the disease is from the sketches alone, especially at the early stages of the disease.

Electrophysiological testing to measure peripheral nerve conduction properties is not a viable alternative because current methods lack the sensitivity required to detect damage to small, unmyelinated fibers, especially in early stages of disease.

«Unfortunately, most clinical trials to date have focused on patients whose cognitive deficits are already mild to severe, and when the therapeutic opportunities in this late stage of the disease are minimal.

Identifying which genes define this critical tumor state provides researchers and clinicians biomarkers of this critical stage of disease progression.

The trial has also included 10 HER -2-negative breast cancer patients, all of them in early stages of the disease.

In the early stages of the disease, however, tau proteins undergo changes that nudge them off microtubules.

The AUC for those patients was 0.87 for Stage I / IIA, 0.93 for Stage IIB and 0.89 for all early stages of the disease using the combination, pointing to a potential ability to detect disease in those who lack either of those known risk - raising conditions.

«We believe that we have made an important step forward in minimising post-operative complications for patient with early HNSCC, enabling a more accurate identification of the stage of their disease, and reducing the cost to healthcare systems at the same time,» Prof de Bree will conclude.

«Based on the results of this study, the side of origin of CC [colon cancer](left vs. right) should be acknowledged as a criterion for establishing prognosis in both earlier and advanced stages of disease.

While the probability of HIV transmission varies with the stage of the disease and the type of sexual contact, it appears to pass from infected to uninfected individuals in less than 1 percent of acts of unprotected heterosexual intercourse, while the corresponding probability of HPV transmission is thought to be higher than 5 percent — probably much higher.

The team is now planning a larger trial in people who have earlier stages of the disease.

Treatment of knee osteoarthritis is shifting focus from end stage treatment to preventing the progression from early to the late stage of the disease, with the specific aim of decreasing the need for joint replacement and other costly treatments.

Whereas Murphy's patients were selected for the recent onset of symptoms, the children arriving at Stanford had progressed to advanced stages of the disease without appropriate treatment.

«For instance, diagnostic tests could be tailored to different strains or stages of the disease,» and vaccines could be designed to skirt interaction with the human body.

To the extent that the HCP - A inventory contains dementias in waiting, scientists may explore hypotheses about the nascent stages of disease.

According to Dr. Xu, nearly 80 percent of pancreatic cancer cases are diagnosed in the late stages of the disease when «cancer is very aggressive and typically spreading throughout the body.»

The finding may provide insight into why African - Americans are more likely to die of colon cancer than Caucasians with the same stage of disease.

«Our findings show that a specific genetic marker (known as allele * 2 of the HS1, 2 A enhancer region) influences not just disease activity in RA patients, but also response to therapy in the early stages of their disease,» said lead investigator Dr Gabriele Di Sante of the Institute of Rheumatology and Related Sciences, Catholic University of the Sacred Heart, Rome, Italy.

The technology can also easily be modified to detect multiple types of peptides released by different types or stages of disease.

In the final stage of the disease, the plant topples over, its fruit bunch inexorably lost.»

Motor neurons in the brain are not lost until the final stages of the disease, but starting very early in the process they appear to exist in a dysfunctional form.

Rather than looking at what distinguished two forms of retinitis pigmentosa, or RP, a progressive blinding disease, they looked for what they had in common: specifically, what genes were expressed at the later stages of disease.

However, the researchers found that stopping neurogenesis before the development of seizures had a long - lasting effect, suppressing chronic seizure frequency for nearly one year, even at a late stage of the disease.

«If we could perhaps modulate these pathways and prolong survival of photoreceptor cells, we might be able to delay any further degeneration even when intervening at these later stages of disease.»

«Our data suggests that targeting specific immune cell subsets at defined stages of disease may represent a better approach to therapeutic immunomodulation to improve heart failure.»

«However, these pharmacological and surgical treatments address the patient's symptoms, such as to improve mobility functions in the early stages of the disease, but the treatments can not slow down or stop the disease process,» Prof Kim explains.

This results in as many as 16 patient groups for this benefit assessment, which mainly differ in type of virus, pretreatment and stage of disease.

McCauley, looking at the earliest stages of the disease, wanted to take Hawkins» purified lung cells to the next step and figure out how they became airway cells.

While vision screening probably isn't harmful, some age - related eye conditions like macular degeneration and cataracts may be difficult to detect before patients have pronounced symptoms because people in the early stages of these diseases may still be able to read eye charts used to test vision.

By comparison, another 96 Alzheimer's patients who were at a similar age and stage of the disease rose by up to six points.

The entorhinal region is one of the first parts of the brain affected by Alzheimer's disease, so the findings may also help to explain why people start to get lost in the early stages of the disease.

People in the study with more severe stages of the disease did not have lower levels of caffeine in the blood, suggesting that the decrease occurs from the earliest stages of the disease, according to David G. Munoz, MD, of the University of Toronto in Canada, who wrote an editorial accompanying the study.

Researchers and doctors are excited about the discovery, as there are no oral therapies approved in Canada for use at this very early stage of the disease.

However, in the early stages of disease these «biomarkers» can be difficult to detect, as they are relatively rare.

In this regard, intense research efforts are being channelled into finding new biological markers that can provide information about the different stages of the disease and allow its early detection, and thus facilitate its management.

During the later stages of the disease, patients experience seizures, become wheelchair bound and can have trouble swallowing.

Estimates show that a five - year delay in the terrible and expensive dementia stage of the disease would reduce Medicare dementia costs by nearly 50 percent.

Participants enrolled in the Study in Parkinson Disease of Exercise (SPARX) were at an early stage of the disease and not taking Parkinson's medication, ensuring the results of the study were related to the exercise and not affected by medication.

After adjusting for age, race / ethnicity, facility type, ZIP code - based income and education levels, and U.S. Census region, it was found that uninsured males were 1.51 times more likely to be diagnosed at a distant stage of disease compared with patients with private insurance.