Not exact matches
Lilly faced a devastating clinical setback last year with a late -
stage failure
for its experimental Alzheimer's
treatment, the studies
for which cost the company hundreds
of millions
of dollars.
Furthermore, an early -
stage study pumping up the dose
of its hemophilia A
treatment — which aims to be a one - time therapy
for the rare blood clotting - related disease — appeared to hit its targets without serious side effects.
CalciMedica is a privately - held, clinical
stage biopharmaceutical company focused on CRAC channel drug discovery and development
for the
treatment of acute and chronic inflammatory diseases.
There is no current
treatment for Zika and vaccines to protect against it are in the earliest
stages of development.
Sierra Oncology, Inc., a clinical
stage drug development company focused on advancing next - generation DNA damage response therapeutics
for the
treatment of patients with cancer, went public near $ 29 in July 2015, then began a downtrend that continued through a June 2017 all - time low
of $ 1.10.
Gain Therapeutics (www.gaintherapeutics.com) is a preclinical
stage biotech company developing a class
of next generation pharmacological chaperones
for the
treatment of devastating rare diseases using the SEE - Tx technology.
Our goal is to complement the current strategic interest
of Chiesi Farmaceutici in the space
of rare diseases by investing in early
stage opportunities and accelerate the expansion
of the Chiesi network in the US among universities, venture capital investors, rare disease patient organizations and start - ups developing
treatments for rare diseases.
Cirius Therapeutics, a clinical -
stage pharmaceutical company, is developing MSDC - 0602K, a next - generation insulin sensitizer
for the
treatment of nonalcoholic steatohepatitis (NASH).
Risk Versus Reward: The Value
of Cell Therapy
for Patients and Investors Source: Streetwise Reports (4/25/18) The cell therapy space, encompassing disruptive new
treatment including stem cell therapy, immunotherapy and gene editing, has begun to mature, with a handful
of product approvals and others in late -
stage development.
Patisiran was being evaluated in a late -
stage study against a placebo
for the
treatment of patients with hereditary ATTR (hATTR) amyloidosis with polyneuropathy.
Maastricht, The Netherlands, 1 November 2017 — Cristal Therapeutics, a clinical
stage biopharmaceutical company developing targeted nanomedicines
for the
treatment of cancer and other diseases with high unmet patient need, announced today that it has begun a Phase 1b...
These strategies are expected to benefit from the preservation
of the tax
treatment of equity - based compensation, which is key to early -
stage growth companies — and also from the tax law's provisions that make it easier
for employees
of start - up companies to exercise their stock options.
It is even more difficult to determine what import a person's being in various
stages of the dying process should have
for ethical decisions about
treatment.
On her biggest
stage yet, Fiorina deserves applause
for forcefully raising Planned Parenthood's
treatment of the unborn and the associated political avoidance practiced by many in both parties.
Alfie Evans» parents, who live in Liverpool, are using a piece
of ancient English common law during the latest
stage of their fight
for treatment.
When researching technologies suitable
for wastewater
treatment and biogas production, CST recommends partnering with a reliable team from conceptual to implementation
stage and beyond into the operation
of the plants.
Prime Minister Julia Gillard's office has taken responsibility
for managing the final
stages of negotiations as the retailers»
treatment of suppliers emerges as a bigger issue among voters in recent polling.
The 1 MG ADI - BVF anaerobic unit can also treat moderate - to - high concentrations
of organic compounds, suspended solids, and fat, oil, and grease (FOG) in a single
stage and typically without the need
for primary
treatment, according to Evoqua.
The disease was deemed to be in its later
stages by a Lyme disease specialist when it was diagnosed, who then recommended a
treatment program
of intensive antibiotic therapy
for several months.
So the Sunday
stage belonged exclusively to a pair
of underdogs who have minuscule Q ratings but were exceedingly easy to root
for: Ted Purdy, who endured an eight - year exile on the Asian and Nationwide tours and finally last year, at age 30, earned a place on the PGA Tour, only to be haunted by a pair
of tournaments that he let slip away; and 22 - year - old Sean O'Hair, whose boyish smile and gentle manner belie the brutal
treatment he had to endure from a father obsessed with driving his son to success.
For the purposes of this economic evaluation, the forms were initially used in a related study funded by the National Institute of Health Research (NIHR) research for patient benefit programme «assessing the impact of a new birth centre on choice and outcome of maternity care in an inner city area,» which will be reported in full elsewhere, comparing the costs of care in a free standing midwifery unit with care in an obstetric unit in the same trust.16 The data collected included details of staffing levels, treatments, surgeries, diagnostic imaging tests, scans, drugs, and other resource inputs associated with each stage of the pathway through intrapartum and after birth ca
For the purposes
of this economic evaluation, the forms were initially used in a related study funded by the National Institute
of Health Research (NIHR) research
for patient benefit programme «assessing the impact of a new birth centre on choice and outcome of maternity care in an inner city area,» which will be reported in full elsewhere, comparing the costs of care in a free standing midwifery unit with care in an obstetric unit in the same trust.16 The data collected included details of staffing levels, treatments, surgeries, diagnostic imaging tests, scans, drugs, and other resource inputs associated with each stage of the pathway through intrapartum and after birth ca
for patient benefit programme «assessing the impact
of a new birth centre on choice and outcome
of maternity care in an inner city area,» which will be reported in full elsewhere, comparing the costs
of care in a free standing midwifery unit with care in an obstetric unit in the same trust.16 The data collected included details
of staffing levels,
treatments, surgeries, diagnostic imaging tests, scans, drugs, and other resource inputs associated with each
stage of the pathway through intrapartum and after birth care.
So, it is mostly used
for mild and moderate depression or in later
stages of treatment.
However, if you suspect that everything is not all right with your baby, do not hesitate to see a doctor immediately, as the symptoms
of pneumonia and other similar illnesses mimic those
of the common cold in the initial
stages, and the earlier
treatment is sought, the lower the risks
for the baby.
As part
of her
treatment, Lee underwent a double mastectomy
for early
stage breast cancer.
Stage two was to widen diversity
of supply to create new incentives
for better local performance and more choice
for patients - a success story in achieving the shortest ever waiting times including meeting our commitment to less than eighteen weeks from doctor's appointment to hospital
treatment, and improving the management
of NHS resources through foundation hospitals and the use
of the private sector.
«This is a big step forward
for early -
stage detection
of arthritis that will help start
treatment early and prevent painful and debilitating disease.»
Fundamental understanding
of basic biology has set the
stage for new
treatments for cystic fibrosis
The researchers say that by diagnosing which type
of arthritis a patient will develop at an early -
stage will allow
for appropriate
treatment that will provide the best chance
for effective
treatment and potential prevention.
Editor's note: This story was updated June 21, 2017, to correct the list
of side effects
of the
treatment and to note that it's not just late -
stage cancer patients who might be eligible
for immunotherapy.
AveXis, Inc., a clinical -
stage gene therapy company developing
treatments for patients suffering from rare and life - threatening neurological genetic diseases, announced in July 2016 that the U.S. Food and Drug Administration (FDA) granted Breakthrough Therapy Designation
for the
treatment based on preliminary clinical results from the trial
of AVXS - 101.
«It is early to say that we have a
treatment proposal
for humans because we are in the first
stage of discovery.
There is currently no effective
treatment for this
stage of leukemia, and patients have only a 5 percent chance
of survival over five years.
Although, still at a pre-clinical
stage, these findings have important potential implications
for the future
treatment of patients.
Treatment of knee osteoarthritis is shifting focus from end stage treatment to preventing the progression from early to the late stage of the disease, with the specific aim of decreasing the need for joint replacement and other costly tr
Treatment of knee osteoarthritis is shifting focus from end
stage treatment to preventing the progression from early to the late stage of the disease, with the specific aim of decreasing the need for joint replacement and other costly tr
treatment to preventing the progression from early to the late
stage of the disease, with the specific aim
of decreasing the need
for joint replacement and other costly
treatments.
«At this
stage, the technique would not be ideal
for widespread
treatment or prevention
of rheumatoid arthritis because it's costly and time - consuming.
Whereas Murphy's patients were selected
for the recent onset
of symptoms, the children arriving at Stanford had progressed to advanced
stages of the disease without appropriate
treatment.
While one drug, MEK inhibitor, is usually used in advanced -
stage melanoma, the other drug, CDK4 / 6 inhibitor, palbociclib, is currently FDA - approved
for treatment of Estrogen Receptor - positive breast cancer patients.
The researchers have found a way to record the earliest
stages of an embryo's growth and have filmed
for the first time ever, the moment
of implantation, opening new possibilities
for improved methods
of IVF
treatment and regenerative medicine.
It is difficult at this
stage to foresee the full impact
of post-zygotic mutations in terms
of treatment options
for disease because the study was mainly focused on the technological aspects
of these genetic changes, the researchers say.
Our intention with this study was to assess Ipilimumab as an adjuvant
treatment for patients with completely resected
stage III melanoma at high risk
of recurrence.
Vtesse is currently running a late -
stage clinical trial
of the drug, a large sugar molecule known as a cyclodextrin, in which it is injected by lumbar puncture into the spinal fluid
of children with the disease (see «Why are people fighting over a promising
treatment for a fatal childhood disease»).
Dr Stephen Simpson, director
of research and programmes at Arthritis Research UK added: «This is exciting, novel work in the field
of regenerative medicine, which although in its early experimental
stages, could take us a step closer to our ultimate goal
of a more effective and much - needed new
treatment for the very many people who live with this painful joint condition.»
Christianson said the findings set the
stage for a large - scale investigation
of the brain circuits that work together to orchestrate responses to social emotional information with the hope that such research will lead to better
treatment for people with conditions marked by aberrant social cognition, such as autism or schizophrenia.
«Techniques to correct defective genes in «non-reproductive» cells are already at various
stages of clinical development and promise to be a powerful approach
for many human diseases which don't yet have an effective
treatment.
«We have effective screening tests
for several cancers, which allow physicians and other health - care providers to identify the disease at an earlier
stage — often before symptoms surface — when
treatment is more likely to result in a cure,» said senior author
of the report and IPHI Director Kenneth W. Kizer.
Prior studies that examined the impact
of cancer
treatment decisions on employment showed that patients who received chemotherapy were most likely to experience longer disruptions in or loss
of employment, but changes in breast cancer management in recent years have shifted recommendations away from chemotherapy
for early
stage breast cancer.
Initial results were announced from the Trial Assigning IndividuaLized Options
for Treatment (Rx), or TAILORx, a multi-center prospectively conducted trial
of more than 10,000 women with early
stage breast cancer sponsored by the National Cancer Institute (NCI), part
of the National Institutes
of Health, and led by the ECOG - ACRIN Cancer Research Group (ECOG - ACRIN) with support from Genomic Health, Inc..
Most research has focused on understanding and managing the late consequences
of sepsis while little is known about the changes occurring in the bone marrow at early
stages of the response to bacterial infection, when the opportunity
for effective
treatment might still be available.
«The most important thing
for us in this first
stage has been to present the biological information in a simple but at the same time reliable manner from the point
of view
of data
treatment,
for example correcting systematic biases between experiments that can lead to erroneous conclusions,» adds Rossell, who is now at the University
of Warwick, in the UK.
The high prevalence
of OSA the study found in these cognitively normal elderly participants and the link between OSA and amyloid burden in these very early
stages of AD pathology, the researchers believe, suggest the CPAP, dental appliances, positional therapy and other
treatments for sleep apnea could delay cognitive impairment and dementia in many older adults.