They say their findings, being presented June 2 at the 50th annual meeting of the American Society of Clinical Oncology (ASCO), offered several clinical insights that could lead to different treatment strategies and perhaps influence
staging of advanced melanoma.
Not exact matches
While one drug, MEK inhibitor, is usually used in
advanced -
stage melanoma, the other drug, CDK4 / 6 inhibitor, palbociclib, is currently FDA - approved for treatment
of Estrogen Receptor - positive breast cancer patients.
The new studies find high activity with investigative drugs for
advanced melanoma, and show for the first time that ipilimumab, a treatment already approved for
advanced melanoma, can substantially decrease the risk
of melanoma recurrence in certain patients with earlier -
stage disease.
Moffitt Cancer Center researchers participated in an international phase 3 study that demonstrated that a drug called ipilimumab improves the relapse - free survival
of advanced stage melanoma patients rendered free
of disease surgically but at high risk for relapse.
Researchers wanted to determine if ipilimumab could improve the survival
of advanced -
stage melanoma patients if it was given after the surgical removal
of both their primary
melanoma tumors and their regional lymph nodes.
Adoptive T cell transfer plus dendritic cell vaccination: Patients with
advanced stage of melanoma (NCT00338377)
«This study, designed to determine if CTCs are associated with relapse, detected CTCs in approximately 40 %
of advanced -
stage melanoma patients.»
Do date surgery is considered the most definitive treatment for early -
stage melanoma, but it is rarely curative for the
advanced stages of melanomas [8].
Early
stages of clinical testing, published in the New England Journal
of Medicine, suggest that it may help to shrink
advanced melanoma tumours with BRAF faults.
What is even more impressive is that these responses were seen across all
stages of melanoma, including the most
advanced stage IV cancers.
As St. Ange discovered during her online search, 52 %
of non-Hispanic black patients and 26 %
of Hispanic patients receive an initial diagnosis
of advanced stage melanoma, versus 16 %
of non-Hispanic white patients, according to the Skin Cancer Foundation.
Unfortunately, people
of color are more likely to find out they have
melanoma when it's at an
advanced and less curable
stage.