Sentences with phrase «standard chemotherapy agents»
When used alongside standard chemotherapy agents daunorubicin and cytarabine in a treatment - resistant AML model, 99.7 percent of cancer cells were killed.
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According to the study authors, the results are especially impressive because half of the patients had just finished treatment with the standard class of chemotherapy agents — fluoropyrimidines (e.g. 5 - fluorouracil [5 - FU] or capecitabine [Xeloda]-RRB- but had failed to benefit from them.
The vaccine was tested in a preliminary clinical trial and used with standard chemotherapy and an immune - boosting agent.
It is hoped that combining PD - 1 / PD - L1 monoclonal antibodies with standard chemotherapies or novel hematologic agents may help improve outcomes.
Lead author Professor Ledermann, professor of medical oncology at the UCL Cancer Institute and a Cancer Research UK grantee, said: «A well - tolerated anti-tumour agent that could be used for months or perhaps years as maintenance therapy after standard chemotherapy could be a big step forward and ultimately extend survival.
To combat the nation's third deadliest cancer, the phase 1b / 2 open - label study will explore the combination of standard chemotherapy and two immunotherapy agents: an anti-PD-1 checkpoint inhibitor and a novel antibody targeting CD40, a protein that when activated can drive the immune system to attack tumors.