Sentences with phrase «standard chemotherapy drugs»

NEW HOPE AGAINST RESISTANT BREAST CANCER: Ixabepilone, a compound being investigated by Bristol - Myers Squibb, shows some encouraging effectiveness against metastatic breast cancers that are resistant to three other standard chemotherapy drugs (anthracycline, taxane and capecitabine).

This makes the starter materials for synthesizing the complex far more economical than a number of industry - standard chemotherapy drugs based on platinum.

Das explained that since the compounds they've developed make cancer cells more sensitive to attack, they also remove resistance to standard chemotherapy drugs — a serious problem in current therapies.

To study nanodiamonds» usefulness for cancer treatment, Ho's group attached them to doxorubicin, a standard chemotherapy drug, and injected them into mice with drug - resistant breast and liver cancer.

Not exact matches

The company said a late - stage trial of its cancer drug Abraxane met its main goal of improving the patient's time of survival without worsening skin cancer, when compared to standard chemotherapy.

Paclitaxel and another chemotherapy drug, carboplatin, are considered standard, first - line treatments for advanced ovarian cancer, experts say, and most patients respond to the drugs initially.

The experimental drug nintedanib, combined with standard chemotherapy with paclitaxel, causes a total remission of tumours in 50 % of patients suffering from early HER - 2 - negative breast cancer, the most common type of breast cancer.

In a head - to - head clinical trial comparing standard chemotherapy with the immunotherapy drug nivolumab, researchers found that people with squamous - non-small cell lung cancer who received nivolumab lived, on average, 3.2 months longer than those receiving chemotherapy.

«In the 20 years that I've been in practice, I consider this a major milestone,» she adds, noting that the trial results helped achieve U.S. Food and Drug Administration approval in March to treat such patients whose lung cancer progressed, despite standard chemotherapy.

The combination of drugs appeared less toxic than standard chemotherapy, were relatively inexpensive and should be clinically evaluated, said Dwayne G. Stupack, PhD, the study's senior author and associate professor in the dDivision of Gynecologic Oncology at Moores Cancer Center.

The researchers then used a combination of existing United States Food and Drug Administration - approved drugs to target autophagy and found ovarian cancer cells to be highly sensitive to these drugs in several different mouse cancer models — even among cells resistant to standard chemotherapy.

«In pancreatic, ovarian and liver cancers, we hope that by adding anti-cancer stem cell drugs to standard of care, we can control proliferating cells within the tumor that could otherwise help the tumor regenerate in the face of existing chemotherapies.»

When he and his colleagues gave the mice the standard, maximum tolerated dose of the chemotherapy drug paclitaxel, the tumours roared back as soon as the treatment was stopped.

If it would be possible to identify tumours that have an aberrantly stabilised SOX9 protein, the drugs tested in this study could be used to prevent tumour spread in these patients and improve their response to standard chemotherapy.

Exploiting the same pre-clinical model used for their studies, the researchers are testing the efficacy of this kind of drug candidates against cancer stem cells, and the possibility of identifying combination regimens with standard chemotherapies with minimized toxic effects, with the perspective of their possible application for the treatment of human breast cancer.

In addition, TGen laboratory research also found that PPF increases the effectiveness of a standard - of - care chemotherapy drug called temozolomide (TMZ), and radiation, to treat glioblastoma.

In elderly cancer patients like my father and aunt, who suffer from a variety of chronic health problems, physicians often modify standard treatment regimens — perhaps using two chemotherapy drugs instead of three or lowering standard dosages — in the hope that the revised treatment will work well enough.

In this study, researchers compared the effectiveness of the immunotherapy drug nivolumab (pronounced «nye VOL ue mab,» marketed at Opdivo), with standard - of - care chemotherapy in 541 patients with previously untreated or recurrent non-small cell lung cancer (NSCLC) that expressed PDL - 1 antibodies.

In phase 3 trials for adults with high - risk, secondary AML, there was a statistically significant improvement in overall survival compared to patients who received a regimen using chemotherapy drugs delivered in the standard way.

For patients with cervical cancer that has recurred after treatment or has spread elsewhere in the body, adding the experimental drug cediranib to standard chemotherapy improves tumour shrinkage and adds a modest improvement in progression - free survival, researchers report at the ESMO 2014 Congress in Madrid.

«Women with ovarian cancer gain extra months with addition of drug to standard chemotherapy.»

The trials for chemotherapy side effects — 4 of which were randomized controlled trials — found that medical cannabis was significantly better than anti-nausea drugs standard at the time of study for reducing nausea and vomiting.

Albeit still limited in efficacy, angiogenesis - inhibiting drugs have become part of standard tumor therapy supporting the efficacy of established chemotherapies.

Researchers have found that people with advanced head and neck squamous cell carcinoma and the KRAS - variant inherited genetic mutation have significantly improved survival when given a short course of the drug cetuximab in combination with standard chemotherapy and radiation.

Many standard cancer treatments, including chemotherapy drugs and radiation therapy, damage the DNA of rapidly dividing cancer cells.

As we reported from the conference, the olympiAD trial showed that an ovarian cancer drug can hold some advanced breast cancers at bay longer than standard chemotherapy.

«These studies suggest the potential for dramatically reducing the dose of chemotherapy or radiation and thereby reducing the side effects of standard chemotherapy by enhancing the targeting of cancer therapies using HIV receptor blocking drugs.»

«Unlike standard chemotherapy, HIV - receptor blocking drugs have been proven to be safe and with rare side effects,» said Richard G. Pestell, MD, PhD, MBA, President of the Pennsylvania Cancer and Regenerative Medicine Research Center (PCARMRC).

The trial involves combining standard chemotherapy with a drug that has been found in laboratory studies to attack cancer stem cells.

Packed with practical suggestions, nutritional advice,... View Details Physicians» Cancer Chemotherapy Drug Manual 2018 by Edward Chu (Author), Vincent T. DeVita Jr. (Author) Completely revised and updated for 2018, the Physicians» Cancer Chemotherapy Drug Manual is an up - to - date guide to the latest information on standard therapy and recent advances in the field.

If it would be possible to identify tumors that have an aberrantly stabilized SOX9 protein, caused by inactivation of FBW7, the drugs tested in this study could be used to prevent tumor spread in these patients and improve their response to standard chemotherapy.

But these epigenetic drugs have shown some success in improving patients» response to chemotherapy or immunotherapy, or in overcoming resistance to those standard treatments.

Patients with non-small cell lung cancer (NSCLC) often respond to standard chemotherapy, only to develop drug resistance later, and with fatal consequences.

The international early Phase II trial led by a team based at the Oxford Cancer Research Centre will trial the experimental drug called LY2181308 with advanced non-small cell lung cancer patients who no longer respond to platinum chemotherapy - the standard initial treatment for this group.

Each patient will receive gemcitabine and nab - paclitaxel, two chemotherapy drugs that are standard of care.

Three chemotherapy drugs and a stem - cell transplant — a regimen that far outstripped the standard of care — briefly cured her.

A standard treatment for prostate cancer, chemotherapy uses drugs to inhibit the growth of cancer cells.

This drug is ideally used with standard chemotherapy regimens.