Additionally, adverse reactions of small breeds are 10 times higher than large breeds, suggesting
standard vaccine doses are too high for smaller animals.
Not exact matches
The group that received the high
dose vaccine had a 19.7 percent hospital admission rate versus 20.9 percent in admission for those who received the
standard dose vaccine.
The findings build on earlier research suggesting that the high -
dose vaccine may be better at preventing influenza virus infections and other flu - related outcomes in seniors, including office visits and hospitalizations, compared to the
standard -
dose vaccine.
In the largest nursing home study to date on the effect of high
dose flu
vaccine, researchers found that shots with four times the strength of
standard flu shots significantly reduced the risk of being hospitalized during the influenza season.
When H1N1 viruses circulated during the 2013 - 2014 season, the high -
dose vaccine was not significantly better than the
standard -
dose vaccine at preventing deaths.
The nursing homes in the study were randomly assigned to one of two groups as a care
standard for influenza prevention, with either the regular
dose of the influenza
vaccine or the high
dose vaccine as the care
standard for their residents age 65 and older.
During the 2012 - 2013 season, people who got a high -
dose vaccine were 36 percent less likely to die in the 30 days following hospitalization or an emergency department visit that included a flu diagnosis compared to the
standard -
dose vaccine, the researchers found.
During the 2012 - 2013 season, when H3N2 viruses were dominant, the high -
dose flu
vaccine was 36 percent more effective at preventing deaths in the Medicare beneficiaries studied, compared to the
standard -
dose vaccine.
If you're age 65 or older and go to your doctor or pharmacy for a flu shot, you may be offered two options: the
standard vaccine, or a high -
dose version that packs a stronger wallop to activate the immune system, which is weaker in seniors.
During the following season (2013 - 2014), when H1N1 viruses dominated and the
standard -
dose vaccine had better effectiveness than the previous season, the high -
dose vaccine was not significantly better at preventing deaths among the Medicare patients studied.
Study authors said about one - in - four breakthrough cases of influenza could be prevented if the high -
dose vaccine were used instead of the
standard -
dose vaccine.
Researchers concluded that the high -
dose vaccine is safe, induces significantly higher antibody responses, and provides superior protection against laboratory - confirmed influenza illness compared to
standard dose among persons over 65 years of age.
The multi-center study enrolled 31,989 participants from 126 research centers in the U.S. and Canada during the 2011 - 2012 and 2012 - 2013 influenza seasons in the Northern Hemisphere in order to compare the high -
dose trivalent
vaccine versus the
standard -
dose trivalent
vaccine in adults over 65 years of age.
This
vaccine works better than the
standard dose and hence I would tell my patients to get the high -
dose vaccine every year.
High -
dose influenza
vaccine is 24 percent more effective than the
standard -
dose vaccine in protecting persons ages 65 and over against influenza illness and its complications, according to a Vanderbilt - led study published today in the New England Journal of Medicine (NEJM).
«Our work so far suggests that this new
vaccine strategy induces a level of virus neutralization about 25 times greater, after a single
dose, than one sees in
standard vaccines,» Weissman said.
Known as the Fluzone High -
Dose vaccine, and made by Sanofi Pasteur, the inactivated influenza vaccine contains four times the amount of antigen that is contained in the standard - dose Fluzone vacc
Dose vaccine, and made by Sanofi Pasteur, the inactivated influenza
vaccine contains four times the amount of antigen that is contained in the
standard -
dose Fluzone vacc
dose Fluzone
vaccine.
But the Congolese government, worried that the virus could spread rapidly among Kinshasa's 10 million residents, has decided to stretch the 1.7 million
doses it has received by giving people 0.1 milliliters of the
vaccine each instead of the
standard 0.5 milliliters.
But a significant reduction in hospitalizations can still be a benefit, Gravenstein said, even though the high -
dose vaccine is more expensive than the
standard -
dose vaccine.
Now, in a paper published in the 11 March issue of Nature, a team led by Bernard Moss of the National Institute of Allergy and Infectious Diseases in Bethesda, Maryland, shows that when monkeys were given MVA followed by the
standard smallpox
vaccine, they were completely protected from a
dose of monkeypox — a close relative of smallpox — that was fatal to unvaccinated animals.
In the paper, the researchers speculate that while the
standard -
dose vaccine might not have been strong enough to stave off illness entirely, it may still have been sufficient to prevent deaths in combination with hospital care.
The study, published in the Journal of Infectious Diseases and funded by
vaccine - maker Sanofi Pasteur, found that — with the exception of one strain of flu circulating in the 2012 - 2013 season — the high
dose flu
vaccine helped participants mount a better immune response to influenza than the
standard flu shot.
Both the high -
dose and
standard flu
vaccines contain inactivated versions of the three influenza strains that world health officials determine most likely to be circulating in a given flu season.
In a comparison between the 781 participants who received the
standard -
dose trivalent inactivated
vaccine and the 1885 who received the quadrivalent inactivated
vaccine, the trivalent
vaccine was not associated with significantly higher odds of influenza, either overall (odds ratio, 1.2; 95 % CI, 0.8 to 1.7) or according to age group (Figure 3).
High -
dose inactivated influenza
vaccine is associated with cost savings and better outcomes compared to
standard -
dose inactivated influenza
vaccine in Canadian seniors.
There is ongoing research on the benefits of giving smaller pets smaller
doses of regular 1 ml
standard vaccines.