This jump -
started cell division is called immune cell activation and is an important component of both normal immune responses and autoimmune reactions.
Not exact matches
I hoped to finally
start studying
cell division.
It was during this time that I
started to explore the literature on bacterial
cell division.
«Why is the
division of egg
cells — which is so important at the
start of animal life — why is that not very reliable?»
«Maybe at the one -
cell or two -
cell stage,» Eggan and his colleagues reasoned, «there's still some of that stuff in there...» And if they picked the right moment of
cell division, when these powerful reprogramming factors were still floating around in the periphery of the
cell, they might be able to use drugs to temporarily freeze the
cell in the middle of
division, stick in the needle of a micromanipulator to suck out the embryonic DNA, squirt in DNA from an adult animal, and then kick -
start the process of reprogramming — hours, perhaps even days after an egg had been fertilized.
Gottschling noticed that after about 25
cell divisions — the equivalent of middle age in humans — DNA errors in daughter
cells started appearing 100 times faster than normal.
We
started this research about 3 years ago, but we were fortunate to be able to identify a triarylmethane compound that can rapidly inhibit
cell division in plants,» he continues.
Even when the researchers helped extend the
cells» life spans by knocking out a problematic gene, the yeast DNA still
started breaking down after 25
cell divisions.
The final component in this long series of signal sequences is the Yorkie effector protein that is the decisive factor at the end of the Hippo signaling pathway and determines the
start of reactivation, growth, and
division in the stem
cells.
«Now that we know exactly how changes in EMSY spur cancer
cell growth, we can
start to design therapies to specifically target that activity and hopefully stop it,» says senior author Douglas Levine, MD, director of the
Division of Gynecologic Oncology at NYU Langone and its Perlmutter Cancer Center.
Baumann suspects that it could happen over two rounds of replication or if two sex
cells combine forces before the
division process
starts.
Since p53 wasn't there to prevent their
division, the return of Plk4 was all that was necessary for the
cells to
start centriole formation again from scratch.
Soon after the egg and sperm join during fertilization, the resultant zygote (fertilized egg
cell)
starts undergoing
cell division.
Like other cancers, breast cancer arises when the
cells of the breast lose control over their
division and
start to invade neighboring tissues.