Sentences with phrase «statin therapy»

A study by investigators at Brigham and Women's Hospital (BWH) published this week in PLOS ONE identifies four factors that may account for sex differences in statin therapy among patients with coronary artery disease (CAD), pointing to interventions and additional research that will be needed to help overcome this sex disparity and reduce cardiovascular risk for women.

«Muscle symptoms experienced by patients on statin therapy may or not be related to the medication,» said the study's lead author, Robert Rosenson, MD, Professor of Medicine and Director of Cardiometabolic Disorders at the Icahn School of Medicine at Mount Sinai.

In addition to identifying patients most likely to benefit from statins, the guideline outlines the recommended intensity of statin therapy for different patient groups.

The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta - analysis of individual data from 27 randomised trials.

«Young adults may be less likely to think that they are at risk of cardiovascular disease, and clinicians may be less likely to initiate statin therapy in this population,» wrote lead author Dr. Emily Bucholz, who's with the department of medicine at Boston Children's Hospital.

New results from the clinical trial program, SPIRE (Studies of PCSK9 Inhibition and the Reduction of Vascular Events), which sought to determine the effect of bococizumab, a PCSK9 inhibitor, on LDL cholesterol levels and clinical outcomes in high - risk patients already taking statin therapy, were presented at the 2017 American College of Cardiology Scientific Sessions and simultaneously published in two manuscripts in the New England Journal of Medicine.

Some patients who do not fall into the four major categories may also benefit from statin therapy, a decision that will need to be made on a case - by - case basis.

This diet is especially important for those who can not tolerate statin therapies to lower cholesterol.

«If we were to view the current findings on the backdrop of contemporary cardiovascular risk calculators and statin guidelines, many patients with connective tissue disease could reasonably consider moderate - intensity statin therapy at age 35,» he said.

• Reduced the risk for CHD events (including revascularization and unstable angina) by 19 %, compared with statin therapy alone.

Trends in Statin Therapy among Adults (Age ≥ 18), United States, 2000 to 2011.

Statins have proven highly effective at decreasing the risk of a second coronary event and current guidelines recommend statin therapy for all adult patients with coronary artery disease.

Risk of incident diabetes with intensive - dose compared with moderate - dose statin therapy: a meta - analysis.

«The unmet medical need remains large for cost - effective therapies that lower cardiovascular risk beyond the risk reduction achieved with standard of care statin therapy alone.

«Our PCSK9 inhibitor data support the notion that lowering cholesterol beyond what is possible with diet, exercise and statin therapy confers benefits to our high risk patients with cardiovascular disease,» said Paul M Ridker, MD, a senior physician at Brigham and Women's Hospital and the Eugene Braunwald Professor of Medicine at Harvard Medical School.

The authors highlight that the trial was conducted in 1998 - 2004, before claims that statin therapy causes high rates of side effects were as widespread as they are today.

Lowering of LDL - C levels by statin therapy modestly increases the risk of type 2 diabetes, but it is unknown whether this effect is specific to statins.

The heart attack patients who enrolled all had high CRP levels and were given the best treatments available, including aggressive statin therapy.

«The recent niacin clinical trials offer important new evidence that raising «good» cholesterol (HDL) levels on top of statin therapy does not have the positive outcome that had been hoped for,» said Neil Stone, M.D., the Robert Bonow MD Professor in Cardiology at Feinberg and a cardiologist at Northwestern Memorial Hospital.

«Early statin therapy helps kids with inherited high cholesterol.»

Patients whose statin therapy was discontinued — that is, patients taking a statin as an outpatient prior to experiencing a hemorrhagic stroke who did not receive a statin as an inpatient — had a mortality rate of 57.8 percent compared with a mortality rate of 18.9 percent for patients using a statin before and during hospitalization.

«Our results suggest statin therapy initiated in childhood reduces disease and death from heart disease in patients with FH,» said Marjet Braamskamp, M.D., study co-author and a Ph.D. student at the Academic Medical Center in Amsterdam, the Netherlands.

«Agatston scoring of coronary artery calcification on routine ungated chest CT has the potential to spare many patients from unnecessary statin therapy,» said principal investigator Michael Kadoch.

«No patient should stop taking their statins based on our study, since statin therapy is a cornerstone in treatment of cardiovascular diseases and has been clearly shown to lower mortality and disease progression,» he says.

In adults with and without CVD who received statin therapy, there was no variation in the relative reduction of CVD risk among the trials after adjustment for LDL - C reduction.

'' I find it hard to fingers to keyboard when you claim cholesterol lowering therapy extends lifespan, even Dietschy admits that Statin therapy users have higher rates of Cancer» Mountains of evidence prove that cholesterol lowering reduces adverse events and does not cause cancer.

Yet they offer not a single study, not even a retrospective study, to substantiate any claim that actively reducing cholesterol through statin therapy would improve the situation for these people.

A systematic review of the cases reported to the FDA determined that approximately half of the memory loss problems occurred within 60 days of starting on statin therapy, although memory problems were reported after taking a statin drug for just 5 days.

Half the statins used worldwide are used in the United States, and that was before the 2001 and 2004 updates of the National Cholesterol Education Program recommended more than tripling the number of Americans taking statin therapy.

«New guideline for management of blood cholesterol: Focuses on lifestyle, statin therapy for patients who most benefit.»

Theranos» tests were more likely to differ from others on cholesterol values, which the researchers said could lead doctors to «either inappropriately initiate or fail to appropriately initiate statin therapy.»

REDUCE - IT is the first multinational cardiovascular outcomes study evaluating the effect of prescription pure EPA therapy, or any triglyceride - lowering therapy, as an add - on to statins in patients with high cardiovascular risk who, despite stable statin therapy, have elevated triglyceride levels (150 - 499 mg / dL).

More than one - third of those patients, for whom new American College of Cardiology / American Heart Association guidelines would recommend statin therapy, were reclassified as being at very low risk for cardiovascular disease.

The «number needed to harm» for intensive - dose statin therapy was 498 for new - onset diabetes - that's the number of people who need to take the drug in order for one person to develop diabetes.

The link between cholesterol and heart disease is disputed, but a 10 per cent drop is in line with what can be expected from statin therapy.

«The new data show a meaningful reduction in cardiovascular events in the highest - risk patients who had the highest LDL cholesterol levels, despite already taking high - intensity statin therapy.»

Women, on average, experience coronary artery disease 10 years later than men and have lower smoking rates than men, both of which may partially contribute to the sex disparity in statin therapy.

This trial, known as REDUCE - IT, could catapult Vascepa into a far larger target market includes patients with moderately elevated triglyceride levels, despite being on statin therapy.

Almost all the patients were on statin therapy.

Six lipid - lowering trials randomized 4,449 patients, who previously had a heart attack or stroke or had extremely high baseline cholesterol levels and were on statin therapy, to receive either bococizumab (150 mg subcutaneously every 2 weeks) or placebo to determine the effects on LDL levels.

Interpretation of the evidence for the efficacy and safety of statin therapy.

The trial included 501 patients with atherosclerotic cardiovascular disease (ASCVD) and elevated LDL cholesterol (> 70mg / ml) despite maximum tolerated statin therapy and patients without ASCVD but with high cardiovascular risk conditions such as diabetes and familial hypercholesterolaemia in whom LDL cholesterol was > 100mg / dl despite maximally tolerated statin therapy.

Muscle - related symptoms are less commonly reported when patients and their doctors are unaware that statin therapy is being used, compared to when they are aware, according to a new study in The Lancet.