Sentences with phrase «stem cell aggregates»
After creating stem cell aggregates with microparticles containing different growth factors, the researchers observed a hemispherical organization of cells for several days, with the different cells remaining spatially segregated.
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The cells aggregate and return to a stem cell - like state to allow them to increase in numbers and generate the specialised cells needed for new tissue formation
«We found that the worms and human cells were almost completely protected from the Huntington's aggregates when we turned on this response,» said Andrew Dillin, the Thomas and Stacey Siebel Distinguished Chair in Stem Cell Research in UC Berkeley's Department of Molecular and Cell Biology and a Howard Hughes Medical Institute investigator.
Groups of stem cells stick together as they develop, forming multicellular aggregates that form spheroids as they grow.
«We can then put the microparticle materials physically inside the multicellular aggregate system that we use for differentiation of the stem cells.
The research builds on the team's previous work with a technique called three - dimensional culture, which involves incubating stem cells in a floating ball - shaped aggregate, unlike traditional cell culture in which cells grow in a flat layer on the surface of a culture dish.
Researchers are now reporting advances in these areas by using gelatin - based microparticles to deliver growth factors to specific areas of embryoid bodies, aggregates of differentiating stem cells.
In the past, scientists have tried to isolate so - called auditory stem cells from embryoid bodie — aggregates of stem cells that have begun to differentiate into different types.
New research suggests that changes to the metabolic profile of aggregated hMSCs enhance stem cell characteristics
Current efforts, mostly conducted in animal models, involve attempting to derive and aggregate embryonic stem cells, exposing them to such factors as acetic acid, allowing them to differentiate, or specialize, and then sorting through these cells to extract the cell types of interest.
This finding complements previous research from the University of Edinburgh and the National Institute for Medical Research which showed that embryonic stem cells can be coaxed into this spinal cord cells; however, the Cambridge researchers showed that the in the embryo - like aggregates, the structural organization is more robust and allows for the polarised growth of the tissue.
Over the years researchers have been making aggregates of embryonic stem cells to obtain certain cell types, for example red blood cells.
Embryoid bodies (EB) are the three - dimensional aggregates formed in suspension by pluripotent stem cells (PSC), including embryonic stem cells (ESC) and induced pluripotent stem cells (iPSC).