Hirano, Egli and colleagues have shown that in unusual cases,
stem cell clones derived from MR eggs can show substantial drift towards the donors mtDNA haplotype after low level mtDNA carryover during the MR procedure.
Not exact matches
To solve this, West proposed «therapeutic
cloning» — taking the nucleus out of a patient's
cell, transferring it into an egg
cell to create a
cloned embryo, then using that embryo to
derive patient - matched
stem -
cell lines.
Consequently, a fundamental argument against using embryonic
stem cells and therapeutic
cloning can not be
derived from existing constitutional law and additional court decisions.
A company called Hematech is already breeding genetically engineered cattle (
derived from
cloned stem cells) that produce human antibodies to fight bacterial infections, and the animals» welfare is not compromised in any way.
In February 2004 Hwang and his research group reported the first embryonic
stem cell line
derived from a
cloned human embryo.
He reported in May 2013 using the Dolly technique, known more formally as somatic
cell nuclear transfer, to
derive stem cells from
cloned human embryos, including from a baby with an inherited disorder.
When a team of South Korean scientists announced in February that they had successfully
derived stem cells from a
cloned human embryo, they trumpeted the potential someday to treat disorders from diabetes to spinal cord injuries.
Rather than
clone humans, researchers take the early stage embryos that result from SCNT and then
derive stem cells (pictured above, fluorescently tagged red).
Still, many medical researchers insist that the
cloning of human embryos continue because the tissue
derived from
stem cells might treat diseases ranging from diabetes to Parkinson's.
Stem cell biologist Shinya Yamanaka said via e-mail that Dolly's cloning motivated him to begin developing stem cells derived from adult cells — an accomplishment that won him a Nobel Prize in 2
Stem cell biologist Shinya Yamanaka said via e-mail that Dolly's
cloning motivated him to begin developing
stem cells derived from adult cells — an accomplishment that won him a Nobel Prize in 2
stem cells derived from adult
cells — an accomplishment that won him a Nobel Prize in 2012.
«It brings closure to the whole story,» says Jose Cibelli of Michigan State University in East Lansing, who has
derived stem cells from monkey parthenotes (Science, 1 February 2002, p. 819) and who at one point advised Hwang on how to distinguish a parthenote from a
clone.
«The use of nonhuman oocytes for SCNT is currently the only ethically justifiable option given the large numbers of eggs required to
derive cloned human
stem cell lines,» he said.
Though Hwang Woo - suk, a South Korean scientist claimed to have created the first human embryonic
clone and
derived a
stem -
cell line from it in 2004 his work was later shown to be fraudulent.
The second method used somatic
cell nuclear transfer (
cloning techniques) to exchange all the mtDNA from the patient's
cells with normal mtDNA from an egg donor in order to
derive embryonic
stem cells that are patient - specific with respect to nuclear DNA, but «rescued» with respect to mtDNA.
The researchers in Oregon say they used those
cloned monkey embryos to
derive embryonic
stem cells.
Using
cloning technology to
derive embryonic
stem cells genetically identical to a patient is potentially very important, not only to provide a source of
cells that may be used to cure patients, but also to allow for genetic disease to be studied and potential drug treatments to be explored in the laboratory.
To investigate quantitatively whether there are restrictions on
cell movement and / or differentiation along the a / p axis, we marked
stem cells at a relatively low frequency to avoid generating two adjacent
clones derived from different regions.