Sentences with phrase «stem cell component»

Not exact matches

2 - D cell - culture and mouse experiments also provided key evidence of the virus's modus operandi; although the rodent brain doesn't harbor the full contingent of human neural stem cells, it has blood vessels and immune - system components that organoids lack.

Investigators at the Cedars - Sinai Heart Institute — whose previous research showed that cardiac stem cell therapy reduces scarring and regenerates healthy tissue after a heart attack in humans — have identified components of those stem cells responsible for the beneficial effects.

It is well known that ribosome biogenesis is a key component of the cell cycle as it regulates cell size and growth and the IBS team has uncovered that SSUPs play a critical role in maintaining induced pluripotent stem cell integrity.

Verfaillie and colleagues were trying to grow stem cells extracted from rodent mesenchyme, a component of bone marrow that contributes to fat, skeleton and muscle.

The final component in this long series of signal sequences is the Yorkie effector protein that is the decisive factor at the end of the Hippo signaling pathway and determines the start of reactivation, growth, and division in the stem cells.

The surprising discovery made by the Dresden - based researchers: two components in the stem cell environment — the extracellular matrix and thyroid hormones — work together with a protein molecule found on the stem cell surface, a so - called integrin.

The research team led by Prof. Fiona Doetsch at the Biozentrum of the University of Basel has now shown that the choroid plexus is a key component of the stem cell niche, whose properties change throughout life and affect stem cell behavior.

«The significance of this study expands beyond the limits of AHDS research, to the possibility of stem cell modeling the blood - brain barrier component in many other neurological diseases,» Vatine says.

«A better understanding of how inflammation affects stem cells and other components of tissue will revolutionize our understanding of many diseases, including cancer, and likely lead to novel therapies,» Naik says.

He said he used techniques to differentiate pluripotent stem cells into cells that are designed to become neural tissue, components of the central nervous system or other brain regions.

«This is the first time anyone has made scalable amounts of epithelial stem cells that are capable of generating the epithelial component of hair follicles,» Xu says.

The findings suggest that the epilepsy component of this syndrome may stem from faulty protein transport in the cell, which in turn may overexcite brain networks in the cerebral cortex.

Researchers applied the findings to a mouse model with a genetic mutation in a component of the ribosome — the machinery that makes proteins — and the rate of protein production was reduced in stem cells by 30 percent.

A few years ago, Dr. Funderburgh and other University of Pittsburgh researchers identified stem cells in a layer of the cornea called the stroma, and they recently showed that even after many rounds of expansion in the lab, these cells continued to produce the biochemical components, or matrix, of the cornea.

My post-doctoral work on the identification of genes required for normal germ line development and fertility led to the discovery that the germ line is exquisitely sensitive to mutations in components of the mitotic spindle that have the potential to lead to aneuploidy — this sensitivity may also extend to embryonic and adult stem cells.

Regina Duryagina (Bornhäuser, TUD)-- «Role of Jagged - 1 and extracellular matrix components for the maintenance of hematopoietic stem and progenitor cells during ex-vivo expansion» (2013)

Research in his Laboratory of Stem Cell Bioengineering (LSCB) is at the interface of stem cell biology and biomolecular engineering to gain fundamental insight into how protein components of niches control the fate of adult stem ceStem Cell Bioengineering (LSCB) is at the interface of stem cell biology and biomolecular engineering to gain fundamental insight into how protein components of niches control the fate of adult stem ceCell Bioengineering (LSCB) is at the interface of stem cell biology and biomolecular engineering to gain fundamental insight into how protein components of niches control the fate of adult stem cestem cell biology and biomolecular engineering to gain fundamental insight into how protein components of niches control the fate of adult stem cecell biology and biomolecular engineering to gain fundamental insight into how protein components of niches control the fate of adult stem cestem cells.

They report in the February issue of Development that support cells called anterior escort cells, located next to the germline stem cells, are a required component of the niche.

Using a discovery platform whose components range from yeast cells to human stem cells, Whitehead Institute scientists have identified a novel Parkinson's disease drug target and a compound capable of repairing neurons derived from Parkinson's patients.

Adult stem cells derived from adipose tissue (fat) are abundant with anti-inflammatory properties and components which stimulate new blood vessel growth.

CAMBRIDGE, Mass. — Using a discovery platform whose components range from yeast cells to human stem cells, Whitehead Institute scientists have identified a novel Parkinson's disease drug target and a compound capable of repairing neurons derived from Parkinson's patients.

Now, in an article in Stem Cells, they report their findings; their determination of the DNA methylation patterns of bCSCs has uncovered important genetic components controlling bCSCs, which impact on the aggressivity and therefore the prognosis for the patient [3].

The major gains in behavioral recovery and neuronal survival achieved by pre-differentiation of glial precursors to specific, beneficial astrocytic cell types prior to transplantation stresses the need to consider such manipulations as a critical component in the optimization of stem / precursor cell transplantation based therapies.

World Stem Cell Summit and Phacilitate Cell & Gene Therapy World is the only event to showcase the global cord blood and perinatal stem cell field while at the same time placing it in its broader strategic context as a critically important component of future cell, gene and immunotherapy business and production modStem Cell Summit and Phacilitate Cell & Gene Therapy World is the only event to showcase the global cord blood and perinatal stem cell field while at the same time placing it in its broader strategic context as a critically important component of future cell, gene and immunotherapy business and production modCell Summit and Phacilitate Cell & Gene Therapy World is the only event to showcase the global cord blood and perinatal stem cell field while at the same time placing it in its broader strategic context as a critically important component of future cell, gene and immunotherapy business and production modCell & Gene Therapy World is the only event to showcase the global cord blood and perinatal stem cell field while at the same time placing it in its broader strategic context as a critically important component of future cell, gene and immunotherapy business and production modstem cell field while at the same time placing it in its broader strategic context as a critically important component of future cell, gene and immunotherapy business and production modcell field while at the same time placing it in its broader strategic context as a critically important component of future cell, gene and immunotherapy business and production modcell, gene and immunotherapy business and production models.

Susan Amara, USA - «Regulation of transporter function and trafficking by amphetamines, Structure - function relationships in excitatory amino acid transporters (EAATs), Modulation of dopamine transporters (DAT) by GPCRs, Genetics and functional analyses of human trace amine receptors» Tom I. Bonner, USA (Past Core Member)- Genomics, G protein coupled receptors Michel Bouvier, Canada - Molecular Pharmacology of G protein - Coupled Receptors; Molecular mechanisms controlling the selectivity and efficacy of GPCR signalling Thomas Burris, USA - Nuclear Receptor Pharmacology and Drug Discovery William A. Catterall, USA (Past Core Member)- The Molecular Basis of Electrical Excitability Steven Charlton, UK - Molecular Pharmacology and Drug Discovery Moses Chao, USA - Mechanisms of Neurotophin Receptor Signaling Mark Coles, UK - Cellular differentiation, human embryonic stem cells, stromal cells, haematopoietic stem cells, organogenesis, lymphoid microenvironments, develomental immunology Steven L. Colletti, USA Graham L Collingridge, UK Philippe Delerive, France - Metabolic Research (diabetes, obesity, non-alcoholic fatty liver, cardio - vascular diseases, nuclear hormone receptor, GPCRs, kinases) Sir Colin T. Dollery, UK (Founder and Past Core Member) Richard M. Eglen, UK Stephen M. Foord, UK David Gloriam, Denmark - GPCRs, databases, computational drug design, orphan recetpors Gillian Gray, UK Debbie Hay, New Zealand - G protein - coupled receptors, peptide receptors, CGRP, Amylin, Adrenomedullin, Migraine, Diabetes / obesity Allyn C. Howlett, USA Franz Hofmann, Germany - Voltage dependent calcium channels and the positive inotropic effect of beta adrenergic stimulation; cardiovascular function of cGMP protein kinase Yu Huang, Hong Kong - Endothelial and Metabolic Dysfunction, and Novel Biomarkers in Diabetes, Hypertension, Dyslipidemia and Estrogen Deficiency, Endothelium - derived Contracting Factors in the Regulation of Vascular Tone, Adipose Tissue Regulation of Vascular Function in Obesity, Diabetes and Hypertension, Pharmacological Characterization of New Anti-diabetic and Anti-hypertensive Drugs, Hypotensive and antioxidant Actions of Biologically Active Components of Traditional Chinese Herbs and Natural Plants including Polypehnols and Ginsenosides Adriaan P. IJzerman, The Netherlands - G protein - coupled receptors; allosteric modulation; binding kinetics Michael F Jarvis, USA - Purines and Purinergic Receptors and Voltage-gated ion channel (sodium and calcium) pharmacology Pain mechanisms Research Reproducibility Bong - Kiun Kaang, Korea - G protein - coupled receptors; Glutamate receptors; Neuropsychiatric disorders Eamonn Kelly, Prof, UK - Molecular Pharmacology of G protein - coupled receptors, in particular opioid receptors, regulation of GPCRs by kinasis and arrestins Terry Kenakin, USA - Drug receptor pharmacodynamics, receptor theory Janos Kiss, Hungary - Neurodegenerative disorders, Alzheimer's disease Stefan Knapp, Germany - Rational design of highly selective inhibitors (so call chemical probes) targeting protein kinases as well as protein interaction inhibitors of the bromodomain family Andrew Knight, UK Chris Langmead, Australia - Drug discovery, GPCRs, neuroscience and analytical pharmacology Vincent Laudet, France (Past Core Member)- Evolution of the Nuclear Receptor / Ligand couple Margaret R. MacLean, UK - Serotonin, endothelin, estrogen, microRNAs and pulmonary hyperten Neil Marrion, UK - Calcium - activated potassium channels, neuronal excitability Fiona Marshall, UK - GPCR molecular pharmacology, structure and drug discovery Alistair Mathie, UK - Ion channel structure, function and regulation, pain and the nervous system Ian McGrath, UK - Adrenoceptors; autonomic transmission; vascular pharmacology Graeme Milligan, UK - Structure, function and regulation of G protein - coupled receptors Richard Neubig, USA (Past Core Member)- G protein signaling; academic drug discovery Stefan Offermanns, Germany - G protein - coupled receptors, vascular / metabolic signaling Richard Olsen, USA - Structure and function of GABA - A receptors; mode of action of GABAergic drugs including general anesthetics and ethanol Jean - Philippe Pin, France (Past Core Member)- GPCR - mGLuR - GABAB - structure function relationship - pharmacology - biophysics Helgi Schiöth, Sweden David Searls, USA - Bioinformatics Graeme Semple, USA - GPCR Medicinal Chemistry Patrick M. Sexton, Australia - G protein - coupled receptors Roland Staal, USA - Microglia and neuroinflammation in neuropathic pain and neurological disorders Bart Staels, France - Nuclear receptor signaling in metabolic and cardiovascular diseases Katerina Tiligada, Greece - Immunopharmacology, histamine, histamine receptors, hypersensitivity, drug allergy, inflammation Georg Terstappen, Germany - Drug discovery for neurodegenerative diseases with a focus on AD Mary Vore, USA - Activity and regulation of expression and function of the ATP - binding cassette (ABC) transporters

«Our method not only uses soluble factors that guide kidney development in the embryo but, by growing and differentiating stem cells on extracellular matrix components that are also contained in the membrane separating the glomerular blood and urinary systems, we more closely mimic the natural environment in which podocytes are induced and mature,» said Musah.

Should stem cell editing occur, the CRISPR components would only need to be expressed for a short period of time, which would prevent the accumulation of unwanted mutations over time.

Oct4 is a key component of the molecular circuitry which regulates embryonic stem cell proliferation and differentiation.

In an earlier study, Jones had shown that the hub cells secrete the self - renewal factor upd, which signals neighboring stem cells to maintain stem cell fate, making hub cells an essential component of the stem cell niche.

We further describe a mesenchymal sub-population with stem cell - like characteristics that gives rise to both lineages and, at the same time, acts as a principal component of the hematopoietic niche by promoting competitive repopulation following lethal irradiation.

Some of their goals include the unravelling of disease mechanisms by using nanomaterials to track cellular components and probe the chemical niche of the cells, the transformation of adult human cells into induced pluripotent stem cells and the delivery of drugs directly to immune and cancer cells.

By studying the stem cells in two types of tissue, namely skin, muscle, and in liver, in young (three months old) and aged (18 to 22 months old) mice every four hours, «we observed that the core components of the circadian clock had no changes in their rhythm with age».

Laminin - 511 is a major component of the basement membrane, which is expressed in early development of the embryo and can be used as a matrix for pluripotent (ES / iPS) stem cells, as it binds to integrin on cell surfaces.

A component found in ginger — 6 - shogaol is superior in targeting and eliminating cancer stem cells, according to another study published in the public library of science.

The point of this program is to «allow the body to enter a full ketogenic mode, meaning it will break down and kill damaged cells and cellular components, activate stem cells, and preferentially decrease visceral and abdominal fat.»

Sulforaphane, a dietary component of broccoli and broccoli sprouts, appears to inhibit breast cancer stem cells.

Sulforaphane, a dietary component of cruciferous vegetables, may inhibit breast cancer stem cells.

The body's natural healing process involves three components: stem cells, growth factors and tissue.