Sentences with phrase «stem cell disorders»
Myeloproliferative neoplasms (MPNs) are a group of related clonal hemopoietic stem cell disorders associated with hyperproliferation of myeloid cells.
http://www.sanger.ac.uk/ Not exact matches
One day, Reynolds says, a version of InVivo's implant, packed with stem cells or hormones, might help the six million Americans who are chronically paralyzed from SCI and other central nervous system disorders improve their level of functioning.
Through CBR ®, we also help families to preserve newborn stem cells, which are used today in transplant medicine for certain cancers and blood, immune and metabolic disorders, and have the potential to play a valuable role in the ongoing development of regenerative medicine.
So hold on tight, I'm gonna share EVERYTHING I've learned so far about cord blood with you... starting with this enlightening link on the general benefits... including the fact that «To date it can treat more than 80 diseases using Haematopoietic Stem Cell (HSC) transplants, including leukemia, sickle cell anemia, and metabolic disorders.&raCell (HSC) transplants, including leukemia, sickle cell anemia, and metabolic disorders.&racell anemia, and metabolic disorders.»
After being a nurse in the PICU, I thought about all of the genetic disorders my patients had encountered, (i.e. various cancers, cystic fibrosis, muscular dystrophy) and I wondered if there were anyway stem cells could have cured or at least improved their conditions.
Passing through a stem cell stage resets the developmental clock to an embryonic - like state, wiping out the age - associated effects of the disorder.
«This model could have far - reaching implications to advance the understanding and treatment of neurological disorders,» said Svendsen, senior author of the Cell Stem Cell study.
Although liver cells created from induced pluripotent stem cells reflect the defects of their source, they may offer a new tool to study inherited disorders
A detour on the road to regenerative medicine for people with muscular disorders is figuring out how to coax muscle stem cells to fuse together and form functioning skeletal muscle tissues.
A team of researchers at the Stanford University School of Medicine has used a gene - editing tool known as CRISPR to repair the gene that causes sickle cell disease in human stem cells, which they say is a key step toward developing a gene therapy for the disorder.
He says the structure could also offer a new way of studying blood stem cells and how blood disorders arise.
In the past decade, a handful of discoveries have unleashed a flood of research into ways neural stem cells can be used for treating degenerative brain disorders and for brain repair.
Stem cells have long been heralded as a potential treatment for a range of brain ailments, but research has so far focused on movement disorders such as Parkinson's disease.
Scientists are a step closer to creating blood stem cells that could reduce the need for bone marrow transplants in patients with cancer or blood disorders.
«Transplanted hematopoietic stem cells reverse damage caused by neuro - muscular disorder: In mouse model of Friedreich's ataxia, a single infusion measurably restored normal cellular functions.»
Harvard Stem Cell Institute (HSCI) scientists have taken the first steps toward developing a treatment that would make bone marrow — blood stem cell — transplantation safer and, as a result, more widely available to the millions of people living with blood disorders like sickle cell anemia, thalassemia, and AStem Cell Institute (HSCI) scientists have taken the first steps toward developing a treatment that would make bone marrow — blood stem cell — transplantation safer and, as a result, more widely available to the millions of people living with blood disorders like sickle cell anemia, thalassemia, and ACell Institute (HSCI) scientists have taken the first steps toward developing a treatment that would make bone marrow — blood stem cell — transplantation safer and, as a result, more widely available to the millions of people living with blood disorders like sickle cell anemia, thalassemia, and Astem cell — transplantation safer and, as a result, more widely available to the millions of people living with blood disorders like sickle cell anemia, thalassemia, and Acell — transplantation safer and, as a result, more widely available to the millions of people living with blood disorders like sickle cell anemia, thalassemia, and Acell anemia, thalassemia, and AIDS.
«Disturbances to these processes may cause neuronal stem cells to develop into different types of cells or may cause neurons to migrate to different locations in the brain, changing neuronal circuitry and potentially leading to behavioral disorders like schizophrenia.»
And to study many developmental disorders, such as fragile X syndrome, researchers would be well served to be able to study a stem cell line that contained the relevant mutations.
Next, she turns to the thrust of her summer project: editing stem cells from the heart to learn more about a congenital heart disorder.
Until then, Semler hadn't considered stem cell transplants a viable treatment for the disorder.
When the Italian government tried to ban an unproven stem cell therapy for neurological disorders, the treatment's supporters — families of people receiving the therapy who thought it was working — protested in the street.
The new epidermis, grown from human pluripotent stem cells, offers a cost - effective alternative lab model for testing drugs and cosmetics, and could also help to develop new therapies for rare and common skin disorders.
In May 2005, Hwang and his colleagues reported that it had produced 11 new human embryonic stem (ES) cell lines that carried the genetic signature of patients with diabetes, spinal cord injury, or a genetic blood disorder (Science, 20 May, p. 1096).
Researchers have harnessed the CRISPR - Cas9 technology to correct mutations in the blood stem cells of patients with a rare immunodeficiency disorder; the engineered cells successfully engrafted in mice for up to five months.
Researchers have developed a new way to study bone disorders and bone growth, using stem cells from patients afflicted with a rare, genetic bone disease.
O'Shea, a professor in the Department of Cell & Developmental Biology and director of the U-M Pluripotent Stem Cell Research Lab, and McInnis, the Upjohn Woodworth Professor of Bipolar Disorder and Depression in the Department of Psychiatry, are co-senior authors of the new paper.
A small skin sample from a person with bipolar disorder can yield stem cells that can be coaxed to become neurons just like those in the brain.
When the team measured gene expression first in the stem cells, and then re-evaluated the cells once they had become neurons, very specific differences emerged between the cells derived from bipolar disorder patients and those without the condition.
Already, we see that cells from people with bipolar disorder are different in how often they express certain genes, how they differentiate into neurons, how they communicate, and how they respond to lithium,» says Sue O'Shea, Ph.D., the experienced U-M stem cell specialist who co-led the work.
«First stem cell study of bipolar disorder yields promising results.»
«Changes in metabolites can regulate earliest stages of development: Findings may offer insights into a variety of disorders, advance embryonic stem cell research.»
«Microenvironment of hematopoietic stem cells can be a target for myeloproliferative disorders.»
One single stem cell from the bone marrow is not going to be able to treat disorders as different as Alzheimer's disease and rheumatoid arthritis,» he says.
British newspapers reported this weekend that Ian Wilmut, the University of Edinburgh biologist who led the team that in 1997 cloned Dolly the sheep, is getting out of the cloning business in light of the new findings, which seem to offer researchers a likely new source of stem cell lines for basic research that could one day lead to new treatments and perhaps cures for spinal injuries, diabetes and debilitating disorders such as multiple sclerosis and Parkinson's disease.
The reality, say leading stem cell researchers, is that every disease and disorder needs its own special formula, including just the right promoter chemicals given at just the right dose, and just the right kind of stem cells introduced at just the right stage.
Other ongoing stem cell trials are targeting blood disorders like aplastic anemia, leukemia, lymphoma, and, of course, sickle - cell disease.
The team has shown that the microenvironment that controls hematopoietic stem cells can be targeted for the treatment of a set of disorders called myeloproliferative neoplasias, the most prominent of which are chronic myelomonocytic leukemia (CMML), juvenile myelomonocytic leukemia (JMML), and atypical chronic myelogenous leukemia (CML).
He is pioneering a new treatment for autoimmune disorders, one in which patients» immune systems are suppressed and then replaced with an infusion of their own immune stem cells, filtered out from their blood.
She is currently at Rockefeller University, where she is studying the interactions between immune cells and stem cells in an effort to develop stem cell - based therapies for inflammatory disorders.
Abatacept, when added to the standard drug regimen used to prevent GvHD, reduced the occurrence of acute, grade III - IV GvHD from 32 to 3 percent in pediatric and adult patients who underwent mismatched unrelated donor stem cell transplants to treat advanced cancer and other blood disorders.
It is anticipated that these results will be used for stem cell treatments for cutaneous disorders associated with various damage and lesions.
«Stem cell therapies hold great promise,» he says, from possible treatments for brain disease to heart disease and age - related disorders.
In a study spanning molecular genetics, stem cells and the sciences of both brain and behavior, researchers at University of California San Diego, with colleagues at the Salk Institute of Biological Studies and elsewhere, have created a neurodevelopmental model of a rare genetic disorder that may provide new insights into the underlying neurobiology of the human social brain.
Meanwhile, neurobiologist Ricardo Dolmetsch, an autism researcher at Stanford University in California, says, «The consensus in the autism research community, as well as in the stem - cell community, is that there is no scientifically valid reason for using stem cells to treat autism spectrum disorders».
In Changchun, Tong Yuan Stem Cell claims to have treated more than 10,000 patients with a variety of disorders, including Parkinson's disease.
A new test may reveal which patients will respond to treatment for graft versus host disease (GVHD), an often life - threatening complication of stem cell transplants (SCT) used to treat leukemia and other blood disorders, according to a study led by researchers at the Icahn School of Medicine at Mount Sinai and published online today in the journal Lancet Haematology and in print in the January issue.
These so - called hematopoietic stem cells (from Greek meaning «to make blood») have been reliably used over the past 40 years to seed bone marrow transplants in the treatment of some cancers and immune disorders.
Shanghai WA Optimum Health Care, for example, which has plush headquarters in a gated estate in one of the wealthiest areas of central Shanghai, claims success in using stem cells derived from umbilical cord or adipose tissue to treat a range of disorders, from autism to multiple sclerosis.
Blood derived from stem cells could be used to help treat leukemia, sickle cell and other disorders.
Currently, there is no cure to stop or reverse any form of muscle - wasting disorders — only medication and therapy that can slow the process,» said Vittorio Sartorelli, M.D., chief of the Laboratory of Muscle Stem Cells and Gene Regulation and deputy scientific director at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS).