Sentences with phrase «stem cell experiment»

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Of the many oddities in the case of Japanese researcher Hisashi Moriguchi, who admitted over the weekend to lying about a startling stem cell experiment, is how for years he managed to claim an affiliation with Harvard Medical School in Boston that did not exist.

Moriguchi's stem cell experiment is «something that's completely eye - catching,» agrees Kevin Eggan, a stem cell biologist at Harvard University and chief scientific officer of The New York Stem Cell Foundation, which held its annual translational research meeting last week.

«The mixtures of cells under debate are called chimeras,» and animal chimeras are used «in a range of developmental biology and stem cell experiments.

The problem follows close on the heels of Hwang's admission that, despite his previous denials, two members of his lab had donated oocytes for his group's stem cell experiments and other donors had been paid for their donations (Science, 2 December, p. 1402).

Scientists see the term in a more positive light, using animal chimeras in a range of developmental biology and stem cell experiments.

Not exact matches

Experiments in animal cells have shown that although these genes are required to form pluripotent stem cells during development, they are not powerful enough on their own to overcome the epigenetic programming of a mature cell and convert it to a pluripotent stem cell directly.

Whilst acknowledging that many questions remain unanswered in the debate between those who would advocate the use of stem cells taken from human embryos, and those experimenting on stem cells drawn from tissues of the adult human body, there is a lengthy discussion of the moral status of the human embryo as being a crucial matter in this regard.

In a preliminary experiment, the team found that stem cells produced from fibroblasts of men with Klinefelter syndrome also lost the extra sex chromosome.

«At face value, it looks very interesting,» says Rudolf Jaenisch, a stem cell biologist at the Whitehead Institute for Biomedical Research in Cambridge, Massachusetts, who hopes that other teams will soon repeat the experiments.

Dr. Zubair, medical and scientific director of the Cell Therapy Laboratory at Mayo Clinic in Florida, says the experiment will be the first one Mayo Clinic has conducted in space and the first to use these human stem cells, which are found in bone marrow.

Experiments on Earth using microgravity have shown that stem cells — the master cells that produce all organ and tissue cell types — will grow faster, compared to conventionally grown cells.

The results of the experiment appear in the April 30 advanced online edition of the journal Nature in a paper titled, «Human embryonic - stem cell derived cardiomyocytes regenerate non-human primate hearts.»

In a series of experiments, the researchers first identified a set of 19 transcription factors that were expressed at significantly greater levels in cultured human glioblastoma stem cells capable of tumor propagation than in differentiated tumor cells.

In experiments on normal and MLL cells from mice and humans, the researchers demonstrated that beta - catenin is activated in cancer stem cells that prompt leukaemic blood cells to multiply.

Those issues emerged 17 years ago, when a Stanford colleague of Greely's proposed implanting human stem cells into mouse brains to see what would happen when the former turned into neurons; the experiment has not yet happened.

Casanova's experiments, published in Cell, point to an almost complete loss of DBR1 as the culprit, enabling brain stem virus invasion in all seven patients.

► The U.S. National Institutes of Health (NIH) has put funding on hold for experiments that involve «mixing human stem cells into very early animal embryos and letting them develop» while it «reconsiders its rules» for this type of research, Gretchen Vogel reported Wednesday.

Lee conducted a real - time attempt to reproduce a controversial experiment published in Nature in which researchers claimed to have turned adult mouse blood cells into pluripotent stem cells.

In August, federally funded work on stem cells was temporarily suspended after a judge ruled that work on hESCs violates a legal amendment in 1995 forbidding funding of any experiments that involve destruction of human embryos.

The two other mouse experiments, published in Cell Stem Cell and Nature, did document microcephaly.

«It is disconcerting that the Italian Senate has passed amendments that permit the use of unproven stem cell therapies without proper vigilance or proper experiment, reclassifying them as transplants,» commented Bianco.

Working with human breast cancer cells and mice, scientists at The Johns Hopkins University say new experiments explain how certain cancer stem cells thrive in low oxygen conditions.

«We believe that our experiments provide the first example of a factor that both expands the intestinal stem cell compartment and builds a niche.»

Additional experiments showed that the protein produced by HMGA1 activates another gene called Sox9, which is directly responsible for turning stem cells into Paneth cells.

Several different experiments localized the active gene and its protein to stem cells buried within the crypts, or deep grooves in the intestinal lining.

The day after his disciplinary dismissal from University of Tokyo for «damaging the university's honor or credibility,» Hisashi Moriguchi maintained in an interview with ScienceInsider that he really did participate in a groundbreaking experiment to treat a heart disease patient with cardiac muscle cells derived from the patient's own induced pluripotent stem (iPS) cells.

The Dolly experiment [which yielded the first cloned adult mammal, Dolly the sheep, in 1996] prompted people to find ways of taking specialized cells and transforming them into pluripotent, undifferentiated stem cells.

2 - D cell - culture and mouse experiments also provided key evidence of the virus's modus operandi; although the rodent brain doesn't harbor the full contingent of human neural stem cells, it has blood vessels and immune - system components that organoids lack.

For the purpose of additional experiments, the researchers generated myocardial cells from embryonic stem cells and human skin cells, in collaboration with the lab headed by Prof Dr Jürgen Hescheler at the University of Cologne.

In lab experiments, the researchers isolated exosomes from specialized human cardiac stem cells and found that exosomes alone had the same beneficial effects as stem cells.

Other experiments expanded the findings to provide clues about the molecular signals that may direct the taste stem cells to go down one path or another.

The final guidelines on research with human embryonic stem cells issued on Monday by the National Institutes of Health set out criteria for determining which ES cell lines can be used in federally funded experiments and give NIH discretion to approve old lines that don't meet stringent modern ethical requirements.

He says the success of the experiment underscores the importance of having human embryonic stem cells available for research.

This enabled adipose - derived adult stem cells to be successfully converted into mature fat cells within the experiments, and the corresponding signalling pathway mTORC1 was also decoded.

The experiment Orwig has in mind is to use gene - editing technology to fix this flaw in the sperm - forming stem cells and then transplant them back into infertile mice, thereby demonstrating a potential treatment for male infertility.

Recent experiments, for instance, suggest that when an organ lacks LGR -5-positive cells, differentiated cells may be able to «dedifferentiate» and repair tissues — a radical change from the one - way street toward specific identities that stem cells were thought to travel.

Mindful of public sensitivities, Daley opted to pursue experiments using what he considers the least controversial human materials to create new nonpresidential stem cell lines — poor quality embryos and oocytes that, in his words, «otherwise would have been disposed of as medical waste.»

In experiments in mice, UC San Francisco researchers have discovered that regulatory T cells (Tregs; pronounced «tee - regs»), a type of immune cell generally associated with controlling inflammation, directly trigger stem cells in the skin to promote healthy hair growth.

After experimenting with several different cocktails, the researchers hit on a mix that transformed 100 percent of cultured stem cells into those that looked like neurons in under an hour.

At the time, culturing stem cells was notoriously hard, but after combing through previous lab experiments, another postdoc in Clevers's lab, Toshiro Sato, concocted a mix of growth factors that coaxed the gut stem cells to replicate in a dish.

They view this as a test run for creating human embryonic stem cells in the same way (and according to the team, South Korean biologist Hwang Woo Suk seems to have accidentally accomplished this feat while executing his famously fraudulent human cloning experiment).

Previous experiments using stem cells from embryos have shown promise in replacing lost cells, but the use of these is controversial.

First, imaging experiments revealed that Tregs have a close relationship with the stem cells that reside within hair follicles and allow them to regenerate: the number of active Tregs clustering around follicle stem cells typically swells by three-fold as follicles enter the growth phase of their regular cycle of rest and regeneration.

There are experiments in using stock market — like systems, in which people bet on ideas to answer seemingly unanswerable questions, like when terrorist events will occur or when stem cell therapy will allow a person to grow new teeth.

Most experiments with human stem cells have only shown that the cells can acquire the phenotype of various differentiated cell types, but have not shown that the cells are functional at the transplantation site.

Treating the potentially blinding haze of a scar on the cornea might be as straightforward as growing stem cells from a tiny biopsy of the patient's undamaged eye and then placing them on the injury site, according to mouse model experiments conducted by researchers at the University of Pittsburgh School of Medicine.

The researchers then confirmed with a controlled experiment that environmental cues were likely to have caused the effect: participants who were primed with images of churches proved less likely to support a stem cell initiative than were subjects who were shown more neutral images, such as office buildings.

And while he considers himself plugged in to the stem cell world, in retrospect Eggan is not surprised that he hadn't heard about this groundbreaking experiment.

Meanwhile the professional story of Colón, now an Oakland Athletic, entered a darker chapter on August 22, 2012, rendering his experiment with stem cells moot.