Sentences with phrase «stem cell factors work»
Together, our results reinforce the idea that EMT and stem cell factors work cooperatively in highly tumorigenic cancer subpopulations and raise interesting questions about their contribution to the increased metastatic capability observed in the cycling hypoxia - selected subpopulation.
https://breast-cancer-research.biomedcentral.com/ Not exact matches
That made working with the mini-brains expensive, given the high cost of the nutrients needed to cultivate human stem cells in the lab, he says, as well as the expense of chemical growth factors that guide the tissue to organize itself like a real brain.
Starting with procedures other research teams had previously worked out to convert iPSCs into keratinocytes, Xu's team demonstrated that by carefully controlling the timing of the growth factors the cells received, they could force the iPSCs to generate large numbers of epithelial stem cells.
Dr Peter Rugg - Gunn, senior author on the research paper and research group leader at the Babraham Institute explained: «This unanticipated connection between stem cell factors and heterochromatin organisation is important because it tells us about how stem cells work.
This post will focus on work done with transcription factors (for more information on using SCNT, see the «Induced Pluripotent Stem Cells...» post).
While Dr. Yamanaka achieved his iPS breakthrough by introducing four factors into adult cells, we're now working on new ways to transform adult cells into stem cells — such as with chemical compounds.
These proteins, called transcription factors, work by changing which genes are expressed in the cell, turning off genes associated with skin cells and turning on genes associated with stem cells.
Our physicians and scientists are working on a number of initiatives, including collecting blood and bone marrow from patients to better understand the causes of bone marrow failure syndromes and MDS; exploring possible genetic factors that guide medical care; collecting blood and bone marrow to identify specific proteins that are faulty and how these defects relate to clinical complications and outcomes; and clinical trials to improve stem cell transplants for disorders such as dyskeratosis congenita.
Our work indicates that only a small fraction of the population resides at the top of the hierarchy, that lineage priming (co-expression of stem cell and lineage specific genes) characterizes pluripotent stem cell populations, and that extrinsic signaling pathways are upstream of transcription factor networks that control pluripotency.
When these growth factors, proteins, regenerative cells, and stem cells are injected into a damaged joint, they go to work immediately.