In the present seminar, I will summarize our findings concerning the role of Srf in myofibers to control muscle mass and I will present recent data identifying Srf as a master regulator of muscle
stem cell fusion and demonstrating the implication of F - actin architecture in this process.
Not exact matches
The new finding brings a measure of closure to a story that first rocked the science world in February 2004, when Hwang and colleagues at Seoul National University announced they had cloned a female donor's
cell by transferring its nucleus into one of her egg
cells stripped of its nucleus in a procedure known as somatic
cell nuclear transfer (SCNT), and harvested embryonic
stem cells from the resulting
fusion.
«While it has been previously shown that ATRA's ability to degrade the leukemia - causing
fusion oncogene PML - RAR causes ATRA to stop the leukemia
stem cells that drive APL, the underlying mechanism has remained elusive,» says Lu.
«These new findings demonstrate that by inhibiting Pin1, you can degrade this
fusion oncogene, thereby stopping cancer
stem cells from replicating.
Figure 2: Abnormal accumulation of the FGFR - TACC
fusion protein (red) in glioblastoma
stem cells isolated from a primary human glioblastoma with fused FGFR - TACC genes.
Application of a novel biodegradable PCL - TCP composite with
stem cells in lumbar interbody
fusion.
Rat adult
stem cells (marrow stromal
cells) engraft and differentiate in chick embryos without evidence of
cell fusion.
Differentiation,
cell fusion, and nuclear
fusion during ex vivo repair of epithelium by human adult
stem cells from bone marrow stroma.
Disproving the claim, Camargo's work revealed that the seeming pluripotency of adult
stem cells was in fact the result of their rare
fusions with
cells in adult tissues.
By transplanting Wnt - activated hematopoietic
stem and progenitor
cells (HSPCs) we demonstrated that Muller
cells can be reprogrammed in vivo after
fusion with HSPCs.
A final chapter mentions future avenues of
cell research, including cloning,
stem cell research, and
cell fusion.
Somatic
cells can be reprogrammed either by nuclear transfer into oocytes or by
fusion with embryonic
stem (ES)
cells.
We have shown that cyclic activation of the Wnt / b - catenin signalling pathway enhances
cell - fusion - mediated reprogramming of a variety of somatic cells (Lluis et al., Cell Stem Cell 2008, Marucci et
cell -
fusion - mediated reprogramming of a variety of somatic
cells (Lluis et al.,
Cell Stem Cell 2008, Marucci et
Cell Stem Cell 2008, Marucci et
Cell 2008, Marucci et al..
Before you consider ankle surgery,
fusion or replacement, consider the world's leading
stem cell and prp injection treatments.
These
cells return to a precursor stage following their spontaneous
fusion with transplanted haematopoietic
stem and progenitor
cells in damaged retinas.
Methods to reprogram primate somatic
cells to a pluripotent state include somatic
cell nuclear transfer [2], somatic
cell fusion with pluripotent
stem cells [3] and direct reprogramming to produce induced pluripotent
stem cells (iPSCs)[4]--[10].