Sentences with phrase «stem cell homeostasis»
How these longevity pathways regulate adult stem cell homeostasis and aging in mammals still remains largely unknown.
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Dissecting the roles of mitochondria in stem cell homeostasis and differentiation is essential to understand stem cell dynamics and fate.
Abstract Our group aims to understand the mechanisms regulating stem cell homeostasis and regenerative functions.
Bruno Pereira, University of Porto, Institute for Research and Innovation in Health - IPATIMUP - RNA - binding protein MEX3A role on intestinal stem cell homeostasis and implications for cancer
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Recently, researchers have begun to describe the function of autophagy, a cellular recycling process critical for homeostasis, in germline stem - cell proliferation of C. elegans.
Scientists study the germline of the roundworm Caenorhabditis elegans to identify the mechanisms that control stem cell proliferation and homeostasis, as well as to advance our molecular understanding of homologous signaling pathways humans.
«The worm was initially used as a model to study embryology and neurobiology, and starting in the late 1990s research expanded into stem cell biology, tissue homeostasis, and regeneration, topics that are still very actively studied today,» he says.
We investigated the role of Srf in two cellular compartments of mouse skeletal muscle (myofibers and adult muscle stem cells) upon different perturbation of muscle homeostasis (hypertrophy, atrophy, regeneration).
Dr. Semenza's research interests include the molecular mechanisms of oxygen homeostasis; gene and stem cell therapy for ischemic cardiovascular disease; the role of HIF - 1 in cancer; and protection of the heart against ischemia - reperfusion injury.
Because the intestine relies on the function of resident intestinal stem cells (ISCs) for survival, its homeostasis is intimately linked to stem cell number.
He and his lab study stem cell biology to provide insights into many areas, such as developmental biology, homeostasis in the normal adult and recovery from injury.
Title: Hematopoietic Stem Cells Reversibly Switch from Dormancy to Self - Renewal during Homeostasis and Repair Authors: Wilson A, Laurenti E, Oser GM, van der Wath RC, Blanco - Bose WE, Dunant C, Bockamp E, Liò P, MacDonald HR, Trumpp A Date: 2008 Publication Details: CELL, 135: 1118 - 1129
AMPKa1 - LDH pathway regulates muscle stem cell self - renewal by controlling metabolic homeostasis
Title: Dll1 - and Dll4 - Mediated Notch Signaling Is Required for Homeostasis of Intestinal Stem Cells Authors: Pellegrinet L, Rodilla V, Liu Z, Chen S, Koch U, Espinosa L, Kaestner K, Kopan R, Lewis J, Radtke F Date: January 2011 Publication Details: Volume 140, Issue 4, Pages 1230 - 1240.
His lab is studying stem cells during development, homeostasis and tumor development.
stem cell therapy for ischemic cardiovascular disease; Molecular mechanisms of oxygen homeostasis; Genetic syndromes due to mutations in genes encoding transcription factors
Examples of these include cell proliferation, intracellular targeting, cell polarity, membrane traffic, cell migration, stem cell biology, chromatin regulation and function, differentiation, morphogenesis and biomechanics, and regeneration and cellular homeostasis, as well as developmental roles of genes, cellular structural dynamics, and signaling pathways.
Our global aim is to characterize the molecular pathways that regulate the behaviour of normal stem cells during homeostasis, and how they become deregulated during carcinogenesis and ageing.
The center brings together leading experts in the diverse fields of neurobiology, stem cell biology, protein homeostasis, proteomics, functional genomics, and clinical neuropathology.
Utilizing sophisticated genetically engineered mouse models, we will study how these conserved longevity pathways regulate the homeostasis and aging of adult stem cells, including hematopoietic stem cells, the adult stem cells that sustain all blood lineages throughout life.
The recent recognition that de novo lipogenesis might have relevance for lipid homeostasis in skeletal muscle stems from the realization that Sterol regulatory element binding protein - 1c (SREBP - 1c), a member of the family of transcription factors that regulate the expression of genes involved in lipid storage in liver and adipose tissue, is also present in skeletal muscle at a level close to that observed in the liver, 41,42... [M] ost fascinating are the very recent demonstrations that glucose alone (in the absence of insulin) can stimulate de novo lipogenesis in skeletal muscle cells....