Sentences with phrase «stem cell in a dish»

Next, the research team will examine specifically whether these liver cells obtained from human embryonic stem cells in a dish help repair injured livers in preclinical animal models of liver disease.

Not exact matches

But the next big question was whether these cells could home in on tumors in lab dishes, and in animals, like neural stem cells.

To develop their «disease in a dish» model, the team took skin cells from patients with Allan - Herndon - Dudley syndrome and reprogrammed them into induced pluripotent stem cells, which then can be developed into any type of tissue in the body.

After deciphering this natural differentiation process, the investigators duplicated it in the laboratory dish by adding a sequence of proteins, called growth factors, to the fluid bathing the stem cells.

In lab dishes, the blast cells formed tissues that resembled blood - forming stem cells as well as blood vessels, the group found.

Researchers say the finding could be harnessed in the future to make an «eye in a dish,» a tool that would be invaluable in coaxing stem cells to develop into ocular tissues.

The team found that exposing samples of human glioblastoma tumours grown in a dish to the Zika virus destroyed the cancer stem cells.

To mimic the physical forces that usually tell fetal stem cells where they can or can't grow, they etched chemical «no - go» zones, creating wells in the dish.

But there are many hurdles: Among them, growing enough of the cells in a petri dish and ensuring that they connect to «the existing machinery» in the eye, says Hendrik Scholl, who co-directs the Center for Stem Cells and Ophthalmic Regenerative Medicine at Johns Hopkins University in Baltimore, Marycells in a petri dish and ensuring that they connect to «the existing machinery» in the eye, says Hendrik Scholl, who co-directs the Center for Stem Cells and Ophthalmic Regenerative Medicine at Johns Hopkins University in Baltimore, MaryCells and Ophthalmic Regenerative Medicine at Johns Hopkins University in Baltimore, Maryland.

Scientists have previously shown that isolated germline stem cells from mice can turn into eggs in a petri dish.

For his prototype he is growing mouse muscle from stem cells in a petri dish.

Zheng, together with Leah Boyer, then a researcher in Gage's lab and now director of Salk's Stem Cell Core, generated diseased neurons by taking skin cells from patients with Leigh syndrome, reprogramming them into stem cells in culture and then coaxing them to develop into brain cells in a dStem Cell Core, generated diseased neurons by taking skin cells from patients with Leigh syndrome, reprogramming them into stem cells in culture and then coaxing them to develop into brain cells in a dstem cells in culture and then coaxing them to develop into brain cells in a dish.

One metabolite featured in the study is cholesterol sulfate, which was found to be used up during osteogenesis on a rigid matrix and in turn could be used to convert stem cells into bone - like cells in a dish.

These transgenic stem cells also readily created intestinal tissues called «organoids» in laboratory dishes.

The disease model, described in a new study by a UC San Francisco - led team, involves taking skin cells from patients with the bone disease, reprogramming them in a lab dish to their embryonic state, and deriving stem cells from them.

«To date, there has been no systematic means of assessing the fidelity of cellular engineering — to determine how closely cells made in a petri dish approximate natural tissues in the body,» says George Q. Daley, MD, PhD, Director of the Stem Cell Transplantation Program at Boston Children's and senior investigator on both studies.

Glioblastomas in lab dishes and mouse brains are fakes, little Potemkin villages that everyone thought were faithful replicas of human glioblastomas but which, lacking tumor stem cells, were nothing of the kind.

Moving forward, he was able to place these taste stem cells in a culture dish and prompt them to grow into the different mature taste cell types, thus creating a taste bud in a dish — scientifically known as taste organoids.

«Alzheimer's in a dish: Stem cells from patients offer model and drug - discovery platform for early onset form of disease.»

The trick, Ali's team found, was to embed the stem cells in a gel instead of growing the cells on top of the dish.

When human stem cells develop into beta cells in a dish, they only reach a precursor stage, unable to fully mature; this prevents them from effectively producing insulin in response to glucose.

Compounds from grapes may kill colon cancer stem cells both in a petri dish and in mice, according to a team of researchers.

At the time, culturing stem cells was notoriously hard, but after combing through previous lab experiments, another postdoc in Clevers's lab, Toshiro Sato, concocted a mix of growth factors that coaxed the gut stem cells to replicate in a dish.

To mimic the physical forces that usually tell fetal stem cells where they can or can't grow, they etched tiny «no - go» zones into the wells of the dish to make the cells grow in the right configuration.

A team of developmental biologists led by Hans Schöler and Karen Hübner at the University of Pennsylvania placed densely packed clusters of stem cells from mouse embryos in a petri dish, using fetal calf serum as a growth medium and adding a gene protein that turns green when germ cells form.

In one dish, the researchers arranged the protein in tiny islands that forced each stem cell to ball uIn one dish, the researchers arranged the protein in tiny islands that forced each stem cell to ball uin tiny islands that forced each stem cell to ball up.

Researchers realized that they could cut open the top of the trunks of their highest - yielding trees, extract stem cells and grow up clones by the thousands in lab dishes.

Their stem cells, which can mature into any type of tissue, were isolated and cultured in a dish around dots of gel - like growth medium.

«Only the pieces that have stem cells in them will reform part of this intestinal crypt structure when you put them in a petri dish,» explains Geiger.

However, it may be possible to partially reverse aging in gut stem cells, at least in a petri dish, researchers report in Cell Reports March 14.

When the researchers added Wnt to petri dishes housing aged stem cells, those stem cells began growing crypts and villi in patterns resembling their younger counterparts.

Further testing in the laboratory dish showed that hematopoietic stem cells from the sleep - deprived mice responded less strongly than their peers to naturally occurring chemical signals that trigger cellular migration.

On laboratory dishes, these stem cells were found to be havens for viral reproduction, resulting in cell death and / or disruption of cell growth.

«The blood - brain barrier forms pretty early in gestation, so the thyroid hormone, even from the mother, is probably not getting through the barrier and into the brain, likely leading to developmental deficits,» says Shusta, whose group was among the first to develop blood - brain barriers from patient - derived stem cells in the lab dish.

Scientists at the Institute of Reconstructive Neurobiology at the University of Bonn applied a recent development in stem cell research to tackle this limitation: they grew three - dimensional organoids in the cell culture dish, the structure of which is incredibly similar to that of the human brain.

The researchers then extracted stem cells from the embryos and grew the cells in dishes in the lab.

The encouraging news is that turning stem cells into auditory neurons can be controlled — at least in a Petri dish, said Kelvin Y. Kwan, senior author of the study and an assistant professor in the Department of Cell Biology and Neuroscience in the School of Arts and Sciences.

They then combined these in a dish with testicular cells from newborn mice in various culture conditions — a process that took hundreds of trials, says author Xiao - Yang Zhao, a stem cell biologist now at Southern Medical University in Guangzhou, China.

Changes in chromatin may help reduce unwanted stem cell proliferation and can be achieved by adding drugs to experimental cultures in Petri dishes, Kwan said.

Stem cells are usually made in a petri dish.

Using cutting edge «disease in a dish» technologies, the researchers are now following up the leads discovered in blood cell lines in neurons induced from stem cells derived from the blood of PMDD patients — in hopes of gaining a more direct window into the ESC / E (Z) complex's role in the brain.

Wells said that it takes about six weeks for stem cells to form gastric - fundus tissues in a petri dish.

Benjamin Reubinoff, Tamir Ben - Hur, and their colleagues at Hadassah University Hospital in Jerusalem, Israel, and Monash University in Melbourne, Australia, took a simpler approach, letting the stem cells multiply in a culture dish until they differentiated on their own.

The research builds on the team's previous work with a technique called three - dimensional culture, which involves incubating stem cells in a floating ball - shaped aggregate, unlike traditional cell culture in which cells grow in a flat layer on the surface of a culture dish.

Now Yoshiki Sasai of the RIKEN Center for Developmental Biology in Kobe, Japan, and his colleagues have induced embryonic mouse stem cells to spontaneously form the optic cup in a dish.

She says that even though Sasai's team hasn't yet grown an entire eyeball in a dish, the work shows that it's possible to grow specific eye structures, such as retinas, from stem cells in a great enough quantity that they could be used in therapy.

When the researchers used fetal breast tissue rather than adult tissue from mice, they were able to pinpoint which cells were stem cells but the cells would rapidly change when grown in a dish.

In culture dishes, ramping up the expression of just four genes can turn skin and other cells into so - called induced pluripotent stem (iPS) cells.

Spike and Gray grew the mammary stem cells in culture dishes and stained them so that new stem cells appeared a different color from differentiated mammary cells.

Both teams successfully used these to reprogramme skin cells in a lab dish into cells resembling embryonic stem cells, which have the ability to turn into any tissue of the human body.