For more on human embryonic stem cells, see Teisha Rowland's «All Things Stem Cell post on «Induced Pluripotent Stem Cells: A New
Stem Cell Line with a Long History,» The National Institute of Health's Stem Cell FAQs, or, for a visual explanation of terms used, see All Things Stem Cell's Visual Stem Cell Glossary.
A new
stem cell line with the mutation for fragile X syndrome may help uncover the mechanism behind the debilitating disorder
Last week, Hwang filed a complaint with the Seoul prosecutor's office claiming that someone had switched
his stem cell lines with ones from MizMedi.
Isolation of amniotic
stem cell lines with potential for therapy.
In this study, published in Stem Cell Reports, the researchers used both murine and human pluripotent
stem cell lines with airway secretory lineage reporters, which enables their tracking, purification and profiling.
Not exact matches
One way to enhance eggs, developed by the company OvaScience, involves supplementing an egg
with mitochondria taken from
stem cells found in the
lining of a woman's uterus.
In all likelihood, soon after he is sworn in, federal dollars will start flowing toward research on new embryonic
stem -
cell lines, bringing
with it new battles to fight.
Not surprisingly, President Obama received high marks from the journal, largely because his response to the question of whether he would lift Bush's ban on the federal funding of new embryonic
stem -
cell lines is in
line with the view of most in the scientific community.
Advocates of embryonic
stem cell research were thought to be in a long
line of pioneers fighting the restraints of religious doctrine to push forward
with scientific research.
He was referring to Intelligent Nutrients, his
line of health and beauty products that meets strict NOP organic standards and focuses on sourcing ingredients in a way that supports the earth, while pushing the envelope
with stem -
cell science to produce maximum - efficacy products.
About three - fourths of the
stem cell lines were found to be unsuitable for research, and many if not all the
lines were contaminated
with mouse feeder
cells.
Studying mice
with injuries to the
lining of the stomach, the researchers blocked the animals» ability to call on
stem cells for help in the stomach.
Collins and others argue not just for a permanent removal of the injunction to resume research
with confidence, but also for an extension of the number of embryonic
stem cell lines available to federally funded researchers.
The team produced 11
stem cell lines from 11 men, women, and children
with conditions such as diabetes, spinal cord injury, and inherited immune deficiency.
«We can work
with any embryonic
stem cell line from any source and are not restricted to working
with the very small number of federally approved
lines as is the case for researchers in the United States,» says Minger.
In one promising approach, cellular reprogramming,
stem cells can be generated by fusing adult skin
cells with embryonic
stem cells from existing
cell lines.
In May 2005, Hwang and his colleagues reported that it had produced 11 new human embryonic
stem (ES)
cell lines that carried the genetic signature of patients
with diabetes, spinal cord injury, or a genetic blood disorder (Science, 20 May, p. 1096).
Furthermore, they have found that neural
stems cells can be culled from the patient's bone marrow, thus circumventing ethical and political obstacles to neural
stem cell therapy as well as problems
with immune rejection that sometimes arise when researchers must employ embryonic
stem cell lines.
While American
stem cell researchers were celebrating the final NIH
stem cell guidelines, questions remain, particularly whether the National Institutes of Health will approve existing
lines in time for use
with stimulus funds.
While he has been working
with federally - approved human ES
lines, he notes that those
lines could be considered illegal until they get vetted by the
stem cell working group NIH plans to create.
Still it is a significant improvement over former President George W. Bush's rules that allowed federal support for work
with only 21
stem cell lines already created from surplus embryos at fertility clinics.
On the other hand, the problem is, you know,
with embryonic
stem cells, they haven't been able to get
stem cell lines from livestock animals that can proliferate in that way, without just sort of veering up in their own direction and turning into, instead of muscle, turning into brain tissue or bone tissue or something else.
The biggest question seems to be whether NIH can approve
lines fast enough that they can be used
with stem cell grants submitted to NIH for the money allocated under the U.S. economic stimulus plan.
The final guidelines on research
with human embryonic
stem cells issued on Monday by the National Institutes of Health set out criteria for determining which ES
cell lines can be used in federally funded experiments and give NIH discretion to approve old
lines that don't meet stringent modern ethical requirements.
The bill was put forth to loosen the restrictions Bush placed on human embryonic
stem cell research on August 9, 2001, when he banned federal funding for work
with any
stem cell line created after that date.
Researchers remove these mechanically and,
with some luck, can nurture them into an embryonic
stem cell line that lives in perpetuity in the laboratory.
Badylak says his
stem cell stimulator is currently being applied,
with great success, to heal injured hearts, thoracic wounds, and the outer
lining of the brain.
One of the most popular models is the immunodeficient nonobese diabetic severe combined immunodeficiency (NOD scid) gamma (NSG) transgenic mouse
line, which can be endowed
with a humanized immune system using CD34 + hematopoietic
stem cells.
In a statement put on the Web this morning, NIH reported that all 64
lines «show characteristics of
stem cell morphology» and have undergone several population doublings, and most of them have demonstrated all the protein markers «known to be associated
with human embryonic
stem cells.»
If there was one embryonic
stem cell, and it differentiated into five distinct specialized
cells, and then these specialized
cells were reprogrammed into five distinct induced
stem cell sets — then at least one of these
lines would be similar to an embryonic
cell with 95 % confidence.
Hajishengallis, Chavakis and their colleagues identified the protein on hematopoetic
stem cells with which Del - 1 interacts, the ß3 integrin, perhaps pointing to a target for therapeutic interventions down the
line.
The nose is
lined with sensory tissue, the olfactory epithelium, that contains various types of
cells, all of which arise from olfactory
stem cells (green).
His group began
with 242 eggs, but after removing the eggs» nuclei and swapping in those of somatic
cells, the investigators produced only 30 blastocysts (week - old embryos), from which they coaxed just one
stem cell line into being.
The university recruited him
with one of the first awards for established investigators from the Cancer Prevention and Research Institute of Texas (CPRIT), a $ 3 billion, 10 - year cancer research fund along the
lines of California's
stem cell initiative.
In people
with SCID, the
stem cells that would become T
cells — one of the immune system's main
lines of defense against infection — lack a crucial protein receptor that tells them to start reproducing.
Later, during a chance discussion
with European colleagues,
stem cell researcher George Daley of Children's Hospital Boston and the Harvard Stem Cell Institute learned that they had received samples of the cell line before the work was retrac
stem cell researcher George Daley of Children's Hospital Boston and the Harvard Stem Cell Institute learned that they had received samples of the cell line before the work was retrac
cell researcher George Daley of Children's Hospital Boston and the Harvard
Stem Cell Institute learned that they had received samples of the cell line before the work was retrac
Stem Cell Institute learned that they had received samples of the cell line before the work was retrac
Cell Institute learned that they had received samples of the
cell line before the work was retrac
cell line before the work was retracted.
Attempting to find middle ground in the contentious debate over human embryonic
stem cells, President George W. Bush announced 9 August that the National Institutes of Health (NIH) will be allowed to fund work
with embryonic
stem (ES)
cell lines — but only those
lines that have already been derived.
Last week the National Institutes of Health (NIH) cancelled its planned meeting of the panel that is supposed to determine whether a given
stem cell line was derived in accordance
with NIH's ethical guidelines (ScienceNOW, 3 April).
With so much work needed in studying the nature of
stem cells and using them to study disease processes, therapies based on ES
cells seem very far down the
line, noted Lorenz Studer of Memorial Sloan - Kettering Cancer Center in New York, who pointed out that so far there have only been two published papers on therapeutic cloning, both of them in mice.
The vessels are
lined with endothelial
cells, which secrete chemical signals that help
stem cell survive.
Pediatric
stem cell transplant and cancer patients often are discharged from the hospital
with an external central venous
line for medications that parents or other caregivers must clean and flush daily to avoid potentially life - threatening infections.
They tested 120 neural
stem cell lines in the lab for stability and robustness and in animals for the capacity to engraft
with minimal immune rejection.
A Phase 3 Open - Label Randomized Study of Quizartinib (AC220) Monotherapy Versus Salvage Chemotherapy in Subjects
with FLT3 - ITD Positive Acute Myeloid Leukemia (AML) Refractory To or Relapsed After First - line Treatment With or Without Hematopoietic Stem Cell Transplantation (HSCT) Consolida
with FLT3 - ITD Positive Acute Myeloid Leukemia (AML) Refractory To or Relapsed After First -
line Treatment
With or Without Hematopoietic Stem Cell Transplantation (HSCT) Consolida
With or Without Hematopoietic
Stem Cell Transplantation (HSCT) Consolidation
This makes a certain kind of sense, since the
stem cells in the paternal germ
line undergo continuous
cell division throughout a man's life, whereas a woman is born
with all of the eggs she'll ever have.
• Subject is refractory to or relapsed after first -
line AML therapy (
with or without hematopoietic
stem cell transplant (HSCT)-RRB-.
The goal of this protocol (written in French) is to describe the steps and quality controls to prepare new stable murine embryonic
stem cells lines: ① either from wild type mouse embryos to introduce a mutation by genetic targeting or homologous recombination to get a genetically modified mouse
line ② or from genetically modified mouse embryos
with two aims:
Establishment of a human embryonic germ
cell line and comparison
with mouse and human embryonic
stem cells.
Establishment of an induced pluripotent
stem cell (iPSC)
line from a patient
with Clozapine - responder Schizophrenia.
To do so, they started
with a human embryonic
stem cell line, which they chemically nudged to become
cells that form what's known as the primitive streak on the hollow ball of
cells of the early embryo.
NeuroStemcell is focused on the identification and systematic comparison of progenitor
cell lines with the most favourable characteristics for mesDA and striatal GABAergic neuronal differentiation, generated either directly from human embryonic
stem (ES) cells, from Neural Stem (NS) cells derived from ES cells or fetal brain, from induced Pluripotent Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals mod
stem (ES)
cells, from Neural
Stem (NS) cells derived from ES cells or fetal brain, from induced Pluripotent Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals mod
Stem (NS)
cells derived from ES
cells or fetal brain, from induced Pluripotent
Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals mod
Stem (iPS)
cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate
cells in appropriate animals models.