Stem cell lines grown in the lab provide scientists with the opportunity to «engineer» them for use in transplantation or treatment of diseases.
Not exact matches
As well as allowing the use of
stem cells grown from established
cell lines, the technology could enable the creation of improved human tissue models for drug testing and potentially even purpose - built replacement organs.
In addition, where
cells derived from embryonic
stem cells are great at proliferating — a potentially critical feature if one wants to
grow sufficient numbers of
cells for clinical use — ones from the iPS
lines were much feebler.
Finally, the team
grew the tissue in a three - dimensional system, which coaxed it into forming all the structures found in gut tissue, including the finger - like villi that protrude inwards to increase surface area, and recesses called crypts containing the intestinal
stem cells that renew the gut
lining weekly (Nature, DOI: 10.1038 / nature09691).
Part of the trouble is the ingredients: Subtle variations in tissue - culture chemicals and Matrigel, or in different
stem cell lines and how they are
grown first in 2 - D culture, can have a big impact on how the organoids turn out, Novitch says.
It performs this critical service in embryonic development,
growing organisms and in a few specialized adult
cell lines, including
stem cells.
Scientists have already reported progress in
growing precursor
cells for eggs and sperm from both iPS and embryonic
stem cell lines.
The group reported
growing multiple parthenogenetic embryonic
stem cell lines by incubating eggs in a warm, low - oxygen culture medium.
To find methods for
stemming the tide of liver - damaging microbes, Schnabl and team tried experimentally bumping up copies of the REG3G gene in intestinal
lining cells grown in the lab.
NeuroStemcell is focused on the identification and systematic comparison of progenitor
cell lines with the most favourable characteristics for mesDA and striatal GABAergic neuronal differentiation, generated either directly from human embryonic
stem (ES) cells, from Neural Stem (NS) cells derived from ES cells or fetal brain, from induced Pluripotent Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals mod
stem (ES)
cells, from Neural
Stem (NS) cells derived from ES cells or fetal brain, from induced Pluripotent Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals mod
Stem (NS)
cells derived from ES
cells or fetal brain, from induced Pluripotent
Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals mod
Stem (iPS)
cells or from in vitro short - term expanded neural progenitors from ventral midbrain
grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate
cells in appropriate animals models.
For the first time since the linkurl: National Institutes of Health; http://www.nih.gov/ released its new guidelines for the derivation of human embryonic
stem cell (hESC)
lines last summer, a
line approved under the Bush administration has been recommended for inclusion into the
growing federal registry of
lines eligible for federal funding.
As researchers look ahead to potential clinical trials with
stem cells, it is becoming apparent that few, if any, of these
lines will have any therapeutic value, in part because they were
grown along with «feeder»
cells from mice.
Cells from these embryos can be used to create pluripotent
stem cell «
lines» —
cell cultures that can be
grown indefinitely in the laboratory.