Sentences with phrase «stem cell marker in»

The ΔN isoforms of p63 may also serve as stem cell markers in a variety of epithelial cell types, including endometrium [30], cervix [31], breast [32], prostate [33], and in stratified squamous epithelium [21,34].

Not exact matches

He proved it in 2003 by first X-raying mice to kill off all the stem cells in their bone marrow, then repopulating the bone with stem cells tagged with a fluorescent marker.

Blood stem cells in the bone marrow have been labeled with a fluorescent marker protein.

When Busch turned on the marker in adult animals, it became visible that at least one third (approximately 5000 cells) of a mouse's hematopoietic stem cells produce differentiated progenitor cells.

Once the stem cells are created, Niklason relies on different chemical markers left behind in the decellularized lungs to guide the stem cells to their correct locations.

Dr Mohamed Elrayess, from ADLQ, said: «In this study we have shown that the impaired ability of fat stem cells to store excess fat was partially due to increased levels of the inflammatory marker interleukin - 6 in the blooIn this study we have shown that the impaired ability of fat stem cells to store excess fat was partially due to increased levels of the inflammatory marker interleukin - 6 in the blooin the blood.

Researchers at Karolinska Institutet have identified cell surface markers specific for the very earliest stem cells in the human embryo.

In a statement put on the Web this morning, NIH reported that all 64 lines «show characteristics of stem cell morphology» and have undergone several population doublings, and most of them have demonstrated all the protein markers «known to be associated with human embryonic stem cells.»

Whitehead Institute researchers have determined that the transcription factor Nanog, which plays a critical role in the self - renewal of embryonic stem cells, is expressed in a manner similar to other pluripotency markers.

Three markers had previously been associated with stem cells in the prostate; these researchers discovered an additional marker dubbed CD117 that allowed them to isolate individual stem cells from the glands in adult mice.

To find out if this was true, workers in stem - cell biologist Irving Weissman's lab at Stanford University Medical School took one blood stem cell from an adult mouse and tagged it with a marker that glowed green under fluorescent light.

But on the right, the deletion of a MicroRNA called miR - 34a causes stem cells (green markers in the top right image and red markers in the bottom right image) to divide out of control.

A series of genetic markers sprinkled throughout the cells» chromosomes show the same pattern found in parthenogenetic mice as opposed to cloned mice, according to a report published online today in the journal Cell Stem Cell.

Mouse embryonic stem cells injected into rat brains express the AHD2 protein marker (yellow) characteristic of cells lost in Parkinson's disease.

This biomechanical marker could be used as a rapid and cost - effective approach to enrich for stem - like cells in corneal transplant tissue.

«In combination with recent advances in sorting cells on a biophysical basis, the biomechanical stemness markers we identified hold the potential to rapidly generate corneal transplants with highly enriched stem cell populations, which could one day translate into better outcomes for these patients.&raquIn combination with recent advances in sorting cells on a biophysical basis, the biomechanical stemness markers we identified hold the potential to rapidly generate corneal transplants with highly enriched stem cell populations, which could one day translate into better outcomes for these patients.&raquin sorting cells on a biophysical basis, the biomechanical stemness markers we identified hold the potential to rapidly generate corneal transplants with highly enriched stem cell populations, which could one day translate into better outcomes for these patients.»

Middle: Immunofluorescence analysis of TRP1 (melanosomes marker) in melanocytes derived from pluripotent stem cells.

However, we have found a fluorescent marker for nestin, a neural crest stem cell marker, in the posterior limbal region of the human anterior segment in the vicinity of both the trabecular meshwork and Schwalbe's line (unpublished).

Expression of the Wnt inhibitor Dickkopf - 1 is required for the induction of neural markers in mouse embryonic stem cells differentiating in response to retinoic acid.

Perivascular cells, including pericytes in the smallest blood vessels (e.g., microvessels) and ARCs around larger ones, express mesenchymal stem cell markers and bear a multi-differentiation fate potential (differentiate into osteoblasts, chondrocytes, adipocytes, smooth muscle cells and myocytes) similar to that documented for MSCs in vitro.

Cancer stem cell markers are enriched in normal tissue adjacent to triple negative breast cancer and inversely correlated with DNA repair deficiency.

Further research uncovered a broad spectrum of cell surface stem cell markers (e.g., CD133, CD44, and CD24) that allow the identification of CSCs in human solid tumors, including brain, breast, prostate, pancreas, liver, ovary, skin, colon cancers, and melanoma (3 - 6)(Figure 1 based on 7).

Telomerase activity has been considered to be a marker for stem cells [23], but it is not found in all stem cell tissues [24].

A lot of effort in tumor stem cell research has always been directed to finding a so - called marker, a molecule whose presence on a cell reliably identifies it as a cancer stem cell.

Corresponding to upregulated TRF2 expression at 80μM, stem cell markers like CD44 and Oct4 were also observed to be upregulated in Clonospheric HCT116 as compared to Parental HCT116 (Fig. 3a and 3b) Decreasing CD24 expression in clonospheric HCT116 was observed which correlated well with increased stem cell expression (Fig. 3b).

Oct - 4 is a transcription factor which has been reported to be involved in various cancers and is also marker for cancer stem cell like population [34, 35].

Review of «In Vitro Cell Motility as a Potential Mesenchymal Stem Cell Marker for Multipotency» from Stem Cells TM by Stuart P. Atkinson

Biological markers of Mesenchymal Stromal Cells as Predictors of response to Autologous Stem Cell Transplantation in Patients with Amyotrophic Lateral Sclerosis; an Investigator - Initiated Trial and in Vivo Study.

Title: Single - molecule transcript counting of stem - cell markers in the mouse intestine Authors: Itzkovitz S, Lyubimova A, Blat IC, Maynard M, van Es J, Lees J, Jacks T, Clevers H, van Oudenaarden A Date: 2011 Publication Details: Nat Cell Bcell markers in the mouse intestine Authors: Itzkovitz S, Lyubimova A, Blat IC, Maynard M, van Es J, Lees J, Jacks T, Clevers H, van Oudenaarden A Date: 2011 Publication Details: Nat Cell BCell Biol.

Now, in a study published in Stem Cells, the laboratory of Seung Hyun Kim (Hanyang University, Seoul, Korea) report on an open ‐ label, single ‐ arm, investigator ‐ initiated trial to identify biological markers of MSCs to predict response to in patients with ALS [3].

Review of «Biological markers of Mesenchymal Stromal Cells as Predictors of response to Autologous Stem Cell Transplantation in Patients with Amyotrophic Lateral Sclerosis; an Investigator - Initiated Trial and in Vivo Study» from Stem Cells by Stuart P. Atkinson

The scientists had strategically inserted these foreign DNA «markers» at particular points along the genome, next to genes expressed only in embryonic stem cells.

Support to date for the existence of an hypoxic niche in marrow blood stem cells came from indirect evidence such as expression of the hypoxia protein Hif - 1 and related genes and staining with surrogate markers of hypoxia.

Phenotypic characterizations reveal high levels of CD44, α2β1 integrin, and β - catenin expression in holoclones, whereas meroclones and paraclones show markedly reduced expression of these stem cell markers.

(A) Expression of 5 stem marker genes in single cells isolated from the edge (E), mid (M) or adjacent center (C) region of HES2 colonies.

(B) Percent of sorted single HES3 cells in (A) expressing stem or lineage markers according to level of surface marker expression.

We have also shown that ΔNp63, a stem cell marker, is not expressed in the human corneal endothelium.

Expression of four stem cell marker genes normalized to cyclophilin in nine single cell equivalents prepared from a pool of nine lysed HES3 cells.

Finally, within the fractionated cell populations, there was evidence for coexpression of lineage specific markers alongside of pluripotency genes, similar to lineage priming described first in hematopoietic stem cells [15].

ΔNp63, a stem cell marker, was not detected in the corneal endothelium.

Oct - 4 is most consistently expressed of the pluripotency genes that we have studied, and it is switched off only in populations that have lost other measurable features of pluripotency, such as stem cell surface marker expression and the capacity for self - renewal.

The fact that all three markers are expressed in essentially all cells in the holoclones suggests that these three molecules are probably expressed in both cancer stem and progenitor cells.

In support, PC3 cell holoclones, but not meroclones and paraclones, express three well - established stem and progenitor cell markers.

His current research interests include developing morphologic and biologic markers of embryo viability in order to enable single embryo transfer and avoid multiple pregnancies; optimizing preimplantation genetic testing; and deriving human embryonic stem cell lines.

Even more profound was a drop in insulinlike growth factor 1 (IGF - 1), which is a biomarker for cancer growth, and an increase in stem cell production, which is a marker for regeneration of cells.

In the same way, whereas NR supplementation increased muscle stem cell number in aged mice, thereby enhancing mitochondrial function and muscle strength, it reduced the expression of cell senescence and apoptosis markers [233]; the state of senescence is important to protect against carcinogenesis [234In the same way, whereas NR supplementation increased muscle stem cell number in aged mice, thereby enhancing mitochondrial function and muscle strength, it reduced the expression of cell senescence and apoptosis markers [233]; the state of senescence is important to protect against carcinogenesis [234in aged mice, thereby enhancing mitochondrial function and muscle strength, it reduced the expression of cell senescence and apoptosis markers [233]; the state of senescence is important to protect against carcinogenesis [234].