Researchers measure the impact on cancer
stem cell metabolism of 3 natural substances, 3 experimental pharmaceuticals and 1 clinical drug.
Not exact matches
«This research represents an important step toward the goal of being able to better treat thyroid diseases and being able to permanently rescue thyroid function through the transplantation of a patient's own engineered pluripotent
stem cells,» explained co-corresponding author Anthony N. Hollenberg, MD, Chief of the Division of Endocrinology, Diabetes and
Metabolism at BIDMC and Professor of Medicine at Harvard Medical School.
The Salford team set out to assess the bioenergetics of cancer
stem cells — the processes which allow the
cells to live and thrive — with a view to disrupting their
metabolism.
«We believe that in obese individuals the muscle
stem cells have been reprogrammed, and that this may partly explain why muscle
cells in obese people have decreased insulin sensitivity and lower
metabolism after they have matured,» says Cajsa Davegårdh.
«Conversely, the necrotic part of the tumor is driven by a distinct set of glioma
stem cells utilizing the BIM1 pathway and are characterized by a mesenchymal, inflammatory
cell type dependent on glucose
metabolism in the absence of oxygen.
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Cell Biology, Physiology, and
Metabolism Cancer Biology Developmental,
Stem Cell and Regenerative Biology Gene Therapy and Vaccines Genetics and Epigenetics Microbiology, Virology and Parasitology
Yu - Hua Tseng, Ph.D., is an Investigator in the Section on Integrative Physiology &
Metabolism at Joslin Diabetes Center, Assistant Professor of Medicine at Harvard Medical School, and Principal Faculty of the Harvard
Stem Cell Institute.
Despite their lack of cBAT, the mutant mice were able to «maintain their body temperature perfectly,» says senior author Yu - Hua Tseng, Ph.D., Assistant Professor of Medicine at Harvard Medical School, Principal Faculty of the Harvard
Stem Cell Institute and an Investigator in the Section on Integrative Physiology and
Metabolism.
He joined the Gladstone Institutes as a postdoctoral fellow in 1993 where his early research into proteins involved in cholesterol
metabolism led him to the study of embryonic
stem cells and differentiation.
Cultured meat is produced by taking
stem cells and placing them in a growth culture (an example would be fetal bovine serum, which is extracted from cow uteruses and is rich with energy substrates, amino acids and inorganic salts to support
cell metabolism and growth).
«Even if
stem cells were ever to be produced, like cloned animals, they would have so many errors of their
metabolism that they would produce completely misleading data.»
The new grant will start January 1, 2017 and provide three years of funding support for Salk research teams drawing from several areas of expertise including cancer,
stem cells and
metabolism.
JAX has particular strengths in research focused on understanding aging, behavior and addiction, computational biology, cancer, development and disease, gene expression, genetics and genomics, immunology and hematology,
metabolism, microbiome, neuroscience, reproductive biology, statistical and population genetics,
stem cells, systems biology, and translational medicine.
This time frame is ideal to support mitochondrial (energy) health, clean out excess toxins, improve
metabolism, and boost
stem cell production.