Sentences with phrase «stem cell model»

In consequence, with the current scientific knowledge, it can only be a backup choice — in absence of embryonic stem cell model.

After creating a stem cell model of the disease from patients» skin cells, the Scripps Research scientists found strong evidence for the involvement of a DNA repair enzyme in the FXN triplet repeat expansion.

«With the new stem cell model, we hope eventually to put together a much more detailed picture of this process of repeat expansion and gene silencing, and that should put us in a good position to devise optimal therapies,» says Professor Joel Gottesfeld.

«With the new stem cell model, however, we hope eventually to put together a much more detailed picture of this process of repeat expansion and gene silencing, and that should put us in a good position to devise optimal therapies,» Gottesfeld said.

A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging

In addition to Loring, Boland and Nazor, authors of the study, «Molecular analyses of neurogenic defects in a human pluripotent stem cell model of Fragile X syndrome,» were Ha T. Tran, Candace L. Lynch and Pietro Paolo Sanna of TSRI; Attila Szücs of the University of California, San Diego, and Eötvös Loránd University; Ryder Paredes of California State University, Channel Islands; and Flora Tassone of the University of California, Davis.

«I hope it will bolster and stimulate the community» to figure out how to better study the cancer stem cell model, he says.

The stem cell model says that tumor growth is more hierarchical, mainly driven by a subset of cells that can make new copies of themselves and give rise to the other cell types the tumor contains.

The cancer stem cell model differs from the traditional idea that tumor growth is equal opportunity — that is, any and all cancerous cells can divide and cause the tumor to grow and spread.

Such cell - tracing techniques are the right approach to test the cancer stem cell model, says Sean Morrison, who studies stem cells and cancer at UTSMC and who was not involved in any of the studies.

In collaboration with Prof. Dr. Roland Schüle and his team at the Center of Clinical Research of the Freiburg University Medical Center, the scientists were able to test several epigenetic inhibitors that had been newly developed by Schüle and his team on the cancer stem cell model.

Stem cell models, derived from healthy or diseased cells, are also being developed for use in drug efficacy and toxicity testing.

«The significance of this study expands beyond the limits of AHDS research, to the possibility of stem cell modeling the blood - brain barrier component in many other neurological diseases,» Vatine says.

In addition to Gottesfeld and Ku, authors of the study, «Friedreich's ataxia induced pluripotent stem cells model intergenerational GAA * TTC triplet repeat instability,» were Elisabetta Soragni, Erica Campau, Elizabeth A. Thomas, Gulsah Altun, Louise C. Laurent, and Jeanne F. Loring of Scripps Research; and Marek Napierala of the University of Texas M. D. Anderson Cancer Center.

Dr. Fossati leads the NYSCF multiple sclerosis research team and has developed an accelerated protocol to create human stem cell models of multiple sclerosis in a petri dish, a crucial step enabling new research around the globe.

NYSCF — Robertson Investigator Alumna Dr. Shuibing Chen published her latest work in Cell Stem Cell creating stem cell models of type 2 diabetes in a...

The Ellerby lab is known for its pioneering studies on Huntington's disease (HD), and Karen is now using human stem cell models of HD to understand why important molecular signaling pathways, such as the TGF - β pathway, are dysregulated in HD.

«Right now, I am really excited about how we can use the HD stem cell models developed in the Ellerby lab to understand the fundamental mechanisms of what causes HD in humans,» she said.

Not exact matches

Drawing on Toronto's leading stem cell and tissue engineering expertise, one group will focus on new models for repairing damaged hearts.

He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.

As well as allowing the use of stem cells grown from established cell lines, the technology could enable the creation of improved human tissue models for drug testing and potentially even purpose - built replacement organs.

«This model could have far - reaching implications to advance the understanding and treatment of neurological disorders,» said Svendsen, senior author of the Cell Stem Cell study.

To develop their «disease in a dish» model, the team took skin cells from patients with Allan - Herndon - Dudley syndrome and reprogrammed them into induced pluripotent stem cells, which then can be developed into any type of tissue in the body.

The team then used murine pluripotent stem cells to regenerate thyroid function in a murine model of hypothyroidism.

«Our research is the first to study Zika infection in a mouse model that transmits the virus in a way similar to humans,» explains Alysson R. Muotri, Ph.D., professor and director of the Stem Cell Program at UC San Diego and co-senior author of the study.

The study results were found using mouse embryonic stem cells, which are good cell models for the study of processes seen in human stem cells.

Using a mathematical model known as the Ising model, invented to describe phase transitions in statistical physics, such as how a substance changes from liquid to gas, the Johns Hopkins researchers calculated the probability distribution of methylation along the genome in several different human cell types, including normal and cancerous colon, lung and liver cells, as well as brain, skin, blood and embryonic stem cells.

They are also testing inhibitors of JAK2, a molecule that influences ADAR1 activity, for their ability to eliminate cancer stem cells in multiple myeloma models.

A new study has found that stem cell therapy can reduce lung inflammation in an animal model of chronic obstructive pulmonary disease (COPD) and cystic fibrosis.

Scientists use mathematical modeling to simulate human mesenchymal stem cell delivery to a damaged heart and found that using one sub-set of these stem cells minimises the risks associated with this therapy.

Researchers, led by Joshua Mayourian at the Icahn School of Medicine at Mount Sinai, used mathematical modeling to simulate electrical interactions between these stem cells and heart cells to develop insight into possible adverse effects, as well as to hypothesize new methods for reducing some potential risks of this therapy.

Testing each of these factors for their ability to return differentiated tumor cells to a stem - like state, identified a combination of four — POU3F2, SOX2, SALL2 and OLIG2 — that was able to reprogram differentiated tumor cells back into glioblastoma stem cells, both in vitro and in an animal model.

Realistic stem cell therapies to replace diseased or damaged tissue may still be years away, but researchers have uncovered a promising new use for these undifferentiated cells: they can be programmed to become patient - specific laboratory models of inherited liver disease.

«Transplanted hematopoietic stem cells reverse damage caused by neuro - muscular disorder: In mouse model of Friedreich's ataxia, a single infusion measurably restored normal cellular functions.»

This study provides a new mathematical model that could be incorporated into future computational studies on mesenchymal stem cells.

Currently, Deng's laboratory is conducting additional preclinical studies using the human - derived stem cells from Down syndrome patients and mouse models to determine whether cellular and behavioral abnormalities can be improved with minocycline therapy and other candidate drugs.

The authors believe that these tools and methods will lay the foundation for crucial breakthroughs in the flatworm model system and in our understanding of stem cell biology and the process of regeneration.

In this reconstituted schematic, hematopoietic stem cells (HSC) transplanted in a mouse model of Friedreich's ataxia differentiate into microglial cells (red) and transfer mitochondrial protein (green) to neurons (blue), preventing neurodegeneration.

Using a mouse model, the team also demonstrated that two processes during neurodevelopment are regulated by the gene: proliferation — the replication of neuronal stem cells that have the potential to become multiple different kinds of cells, including neurons — and migration — the movement of neurons to specific locations in the brain during development.

Researchers at University of California San Diego School of Medicine report that a single infusion of wildtype hematopoietic stem and progenitor cells (HSPCs) into a mouse model of Friedreich's ataxia (FA) measurably halted cellular damage caused by the degenerative disease.

IBMT worked together with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME, which used pluripotent stem cells to develop a model for investigating cardiotoxicity.

This is a breast cancer stem cell line 1 (BCSC1) from the newly established cell model.

Induced pluripotent stem cells (iPSCs)-- adult cells reprogrammed back to an embryonic stem cell - like state — may better model the genetic contributions to each patient's particular disease.

To do this, they created a cellular model of Werner syndrome by using a cutting - edge gene - editing technology to delete WRN gene in human stem cells.

«We have now developed the first model where we can observe the development of a stem cell into a mature blood cell in a living organism.»

The distribution of fluorescent daughter cells can be used to create a mathematical model of blood formation, which can provide new insights into the behavior of stem cells.

In the current study, Dr. Xu and colleagues gave radiation therapy to a mouse model of human pancreatic cancer to eradicate the bulk tumors, while only the cancer stem cells remained in the residual scars.

Next, the research team will examine specifically whether these liver cells obtained from human embryonic stem cells in a dish help repair injured livers in preclinical animal models of liver disease.

More recently, researchers have induced stem cells from diseased human somatic cells, which may serve as new model systems for various illnesses.

«New gene editing technique turns human pluripotent stem cells into a model system for polycystic kidney disease.»