Sentences with phrase «stem cell pathway»

«Researchers discover a new link to fight billion - dollar threat to soybean production: Scientists show that parasitic nematodes hijack vascular stem cell pathways to attack their hosts.»

Additionally, CSCs could provide clues about the novel stem cell pathways activated during cancer progression, which, in turn, could guide further therapeutic steps and clinical trials design.

There is maybe a unique opportunity for brain cancer in targeting stem cell pathways.

Not exact matches

He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.

Cauliflower is high in sulforaphane, a sulphur compound that has been shown to kill cancer stem cells, thereby slowing tumor growth and support liver detoxification pathways.

Stomach switch The key to turning pluripotent stem cells into stomach cells was a pathway of interactions that acts as a switch between growing tissues in the intestine and in the antrum, a part of the stomach near its outlet to the small intestine.

When the stem cells were around three days old, researchers added a cocktail of proteins including Noggin, which suppresses that pathway, and timed doses of retinoic acid, a compound in vitamin A.

According to the study results, YAP is excluded from the nucleus on the soft gels, and its depletion there helps drive the stem cells onto a brain cell developmental pathway.

The team found that connective - tissue cells adjacent to colon cancer stem cells secrete growth factors that activate a molecular pathway in other cells that is vital to maintaining stem - cell - like qualities.

After exploring the molecular pathway in mice, the researchers focused on cardiac stem cells in patients with heart disease.

«Cardiac stem cells from heart disease patients may be harmful: Researchers discover molecular pathway involved in toxic interaction between host cells and immune system.»

Although transcription factors are often the ingredients scientists use to induce stem cell fate, Dalby and Ulijn hypothesize that certain metabolites «fuel» the pathways that result in variable concentrations of transcription factors that drive these changes.

Rare stem - like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, report University of California San Diego School of Medicine and Moores Cancer Center researchers.

Inhibiting ALDH1A3 - mediated pathways slows the growth of mesenchymal glioma stem cells and might provide a promising therapeutic approach for glioblastomas with a mesenchymal signature.

Further investigation, says Resar, showed that these unusual properties arise from the ability of HMGA1 to turn on several genes involved in the Wnt pathway, a network of proteins necessary for embryonic development and stem cell activity.

Using next - generation sequencing technologies that were previously unavailable, Michael Gardner, a graduate research assistant, and Jianying Wang, a senior research associate in Mitchum's lab, made a remarkable new discovery — nematodes possess the ability to produce a second type of peptide that can effectively «take over» plant stem cells that are used to create vital pathways for the delivery of nutrients throughout the plant.

The team's next step is to zoom in on the molecular mechanisms that control how the Wnt signaling pathway interacts with the nail stem cells to influence bone and nail growth.

Researchers at Boston University School of Medicine (BUSM), under the direction of Sam Thiagalingam, PhD, found that a protein secreted by BLBC cells, called periostin (POSTN), acted to nurture and support cancer stem cells by activating a distinct signaling pathway in these cells.

To unravel the complex signaling pathway map, the scientists used their own findings from the analysis of factors regulated up or down in the interplay between tissue and stem cells, linking them with the signaling pathways described in existing literature.

Instead, they discovered that Tregs trigger stem cell activation directly through a common cell - cell communication system known as the Notch pathway.

This enabled adipose - derived adult stem cells to be successfully converted into mature fat cells within the experiments, and the corresponding signalling pathway mTORC1 was also decoded.

Her research has recently shown that a signaling pathway dubbed «hedgehog» is important not only for normal development of stem cells but also for the growth of cancer cells in chronic myelogenous leukemia.

«Here the IGF pathway is conserved but subject to imprinting, which inhibits its activity in quiescent reserve stem cells,» says Li.

She then followed up with a closer look at role of the Igf2 signaling pathway in coaxing quiescent hematopoietic stem cells to start dividing and maturing into multi-lineage progenitors that ultimately give rise to specialized blood cells.

These diets may naturally be providing a shotgun approach to cancer prevention by using a wide variety of beneficial compounds to target multiple pathways that cancer stem cells use to survive.

They found that ONC201 alters the gene expression of cancer stem cell markers and signaling pathways prior to killing the tumor cells, providing pharmacodynamic biomarkers of response.

Scientists study the germline of the roundworm Caenorhabditis elegans to identify the mechanisms that control stem cell proliferation and homeostasis, as well as to advance our molecular understanding of homologous signaling pathways humans.

«Our results with Drosophila exhibit surprising similarities in some respects to what we know about the regulation of resting phases in mammals, allowing for speculation as to whether the Hippo signaling pathway in neural stem cells functions in the same manner in both vertebrates and invertebrates,» stated the paper's first author Rouven Ding.

Protein interactions between niche glial cells and the stem cells activate the Hippo signaling pathway in the stem cells to repress growth and cell division.

The Hippo signaling pathway, which is highly conserved up to humans, was known to play a critical role in organ size determination, like, for example, in the liver, but has not been demonstrated to influence neural stem cells in the central nervous system.

The final component in this long series of signal sequences is the Yorkie effector protein that is the decisive factor at the end of the Hippo signaling pathway and determines the start of reactivation, growth, and division in the stem cells.

«These reserve stem cells that we had shown were important for the beneficial effects of calorie restriction, were repressing many pathways that are all known to be regulated by the protein complex mTOR, which is most well known as being a nutrient - sensing complex.»

Even though Wnt proteins are difficult to manipulate, their ability to reverse intestinal stem cell aging suggests a pathway that clinicians may eventually be able to target.

«In this case, the pathway involved the loss of a protein called MBD3 that allows tumor cells to become more like stem cells and persist,» said first author on the study Rakesh Verma, a postdoctoral associate in hematology.

Brooker and colleagues showed that Prozac and tricyclics inhibit this pathway and, thereby, trigger stem cells in the brain to produce more neurons.

Working in flies and mice, researchers at the Buck Institute and elsewhere discovered that TOR, a nutrient sensing pathway which is central to the aging process, drives the loss of adult stem cells.

«We have known for a long time known that there are important links between inflammation and cancer, including similar pathways that regulate normal and cancer stem cells,» says study author Max S. Wicha, M.D., distinguished professor of oncology and director of the U-M Comprehensive Cancer Center.

The team discovered that the TCL1 protein played a key role in increasing glycolysis by activating a different metabolic pathway that is important for the self - renewal of stem cells.

«We have shown that, in theory, the pathways that control stem cells can be modified to make bigger fruits or more seeds.

«We hope to determine how this pathway might translate into better stem cell therapies for human disease,» added Agrawal.

Jasper says TOR can be regulated by a number of stimuli, and researchers are now attempting to better understand how the activity of this signaling pathway is controlled in stem cells.

«There has been a lot of work on Wnt signaling pathways, for example, so there are a lot of small - molecule drugs that could be tested to trigger a stem cell to mature into a neuron.»

New research from the University of Michigan Comprehensive Cancer Center and Georgia Regents University finds that a protein that fuels an inflammatory pathway does not turn off in breast cancer, resulting in an increase in cancer stem cells.

«Although we demonstrated that BCG educates stem cells to generate trained immunity, we had no idea about the molecular mechanisms that were involved in this protective pathway,» says Dr. Divangahi, who is also an Associate Director of the Translational Research in Respiratory Diseases Program at the RI - MUHC and an Associate Professor of Medicine at McGill University.

The Wnt / β - catenin signaling pathway and microRNA 335 are instrumental in helping form differentiated progenitor cells from stem cells.

Professor Heiko Lickert, director of the IDR, in collaboration with Professor Gunnar Schotta of LMU München, showed that the Wnt / β - catenin signaling pathway regulates Sox17, which in turn regulates molecular programs that assign pluripotent cells to the endoderm, thus inducing an initial differentiation of the stem cells.

However, her research group has not yet identified how to make stem cells yield entirely dI1 or entirely dI3 cells — perhaps because another signaling pathway is involved, she said.

The study, published in Proceedings of the National Academy of Sciences (PNAS), utilized human induced pluripotent stem cells (hiPS cells) to map lithium's response pathway, enabling the larger pathogenesis of bipolar disorder to be identified.

Dr. Sloan said that since a single tumor may contain different pools of glioma stem cells, combined targeting should be considered for the pathways and stem cells.

«Basically it is a mutation that makes potential stem cells, or precursor cells, susceptible to apoptotic cell death pathways.