Sentences with phrase «stem cell renewal»

Heterogeneity in human ES cultures is reflected by the variability in expression of cell surface antigens seen under culture conditions that promote stem cell renewal.

Many HMTs have been implicated in tumorigenesis and progression of multiple malignancies, and play essential roles in embryonic development and stem cell renewal.

The JMJD1A protein is involved in a wide variety of other processes, including cancer, infertility, stem cell renewal, and sex determination of an embryo.

«There's clearly a strong link between aging and stem cell renewal, and this paper went a long way towards suggesting that a circulating factor could play a role.»

«It's all about maintaining a balance between stem cell renewal and differentiation,» said Jasper.

To form an organoid, the stem cells are grown inside three - dimensional gels that contain a mix of biomolecules that promote stem cell renewal and differentiation.

To see whether cancer stem cell renewal involves a chain of events similar to that used by embryonic stem cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two human breast cancer cell lines that responded to low oxygen by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.

Not exact matches

It has been assumed that activation of HOX genes turns normal blood cells into leukemia cells by initiating stem cell - like self - renewal.

In leukemia cells it is often the case that genes are reactivated that, in physiological terms, mediate the self - renewal of blood stem cells.

They are particularly responsible for the self - renewal of blood stem cells.

This intricate regulation process allows stem cells to maintain their ability to undergo self - renewal and form blood vessel - like structures.

Cancer stem cells can reproduce themselves through a process called self - renewal and sustain the growth of a tumor.

The researchers confirmed this hypothesis by showing that if they blocked YAP1 they could inhibit stem cells from undergoing self - renewal, forming blood vessel - like structures, and reduce lung cancer cell growth in mice.

Moffitt researchers found that YAP1 plays an important role in cancer stem cell self - renewal.

To make stem cells the basis for safe medical treatments, however, the field would need the ability to tightly control stem cell pluripotency, the ability to become many cell types, and self - renewal or immortality, the ability to keep dividing and multiplying over time in constant turnover.

Autism risk mutations inactivate this gene and, in the absence of their own ability to produce carnitine and without adequate outside supplementation, neural stem cells become less efficient at self - renewal.

Also limiting the use of therapeutic stem cells to date, self - renewal, a quality so vital to a fast - growing fetus, can also be a source of cancer risk when haphazard, unlimited cell multiplication results in the abnormal tissue growth seen in tumors.

Researchers found that the combination had an enhanced effect on leukemia stem cells, further shifting them from self - renewal back toward maturity and cell death.

The scientists have discovered that the colon has a safety mechanism to prevent the self - renewal of adenoma stem cells.

And with adult stem cells, they don't have the same capacity of self - renewal to double and redouble infinitely.

«Cancer stem cells are capable of self - renewal, cellular differentiation and maintain their stem cell - like characteristics even after invasion and metastasis.»

«Blood stem cell self - renewal dependent on surroundings: Blood formation: Bone marrow, blood stem cells work in close harmony.»

This is essential to maintain the stem cells through self - renewal.

At the same time, self - renewal keeps the stem cell pool replenished.

ONC201 may inhibit cancer stem cell self - renewals by altering their gene expression, according to a study published August 2, 2017 in the open - access journal PLOS ONE by Varun Vijay Prabhu from Oncoceutics, Inc., USA and colleagues.

In addition, many niches contain different stem cell types, each necessary to produce the distinct types of cells needed for tissue renewal.

In CRC 873, funded by the German Research Foundation, medical and biological scientists investigate the basic regulatory mechanisms that control the self - renewal and differentiation of stem cells.

Understanding the mechanisms that regulate the self - renewal and differentiation of stem cells is important, in order that stem cells can be effectively and safely utilised in medical applications in the future.

Whitehead Institute researchers have determined that the transcription factor Nanog, which plays a critical role in the self - renewal of embryonic stem cells, is expressed in a manner similar to other pluripotency markers.

They found that the protein seems to help maintain several traits in normal breast cells, including the ability to adhere to other epithelial cells, and the presence of molecules marking the cells as differentiated and not capable of self - renewal like breast stem cells.

The group examined how a protein called a Wnt is believed to maintain the self - renewal of embryonic stem cells.

In the current issue of the journal Nature, scientists at the Stowers Institute for Medical Research report that competition between two proteins, Bam and COP9, balances the self - renewal and differentiation functions of ovarian germline stem cells (GSCs) in fruit flies (Drosophila melanogaster).

The lab previously found that Bam is required to repress the expression of E-cadherin, a cell - to - cell adhesion molecule that tethers adult stem cells to their tissue niches and promotes GSC self - renewal.

The team discovered that the TCL1 protein played a key role in increasing glycolysis by activating a different metabolic pathway that is important for the self - renewal of stem cells.

The rigorous definition of a stem cell requires that it possesses two properties: Self - renewal - the ability to go through numerous cycles of cell division while maintaining the undifferentiated state.

Ultimately, this activity increases cellular regeneration, or self - renewal, turning white blood cell precursors into leukemia stem cells.

I've still kept my own lab going focusing on understanding what pluripotent stem cells really are, and the extrinsic signals that govern their self - renewal and differentiation.

The process that sets a stem cell on the path to either self - renewal or differentiation was thought to be a highly complex web of genetic and environmental interactions.

This is both a useful tool for giving us a better understanding of the genetic and epigenetic program controlling the self - renewal of stem cells, and on a practical side, it could allow us to inexpensively produce large numbers of immune cells, which could then be used for regenerative medicine or immune therapy.»

«The work is telling us that these [melanocyte] stem cells don't have an infinite capacity for self - renewal,» says geneticist Ian Jackson of the Medical Research Council Human Genetics Unit, U.K..

Reference article: The transcription factor GATA6 enables self - renewal of colon adenoma stem cells by repressing BMP gene expression Gavin Whissell, Elisa Montagni, Paola Martinelli, Xavier Hernando - Momblona, Marta Sevillano, Peter Jung, Carme Cortina, Alexandre Calon, Anna Abuli, Antoni Castells, Sergi Castellvi - Bel, Ana Silvina Nacht, Elena Sancho, Camille Stephan - Otto Attolini, Guillermo P. Vicent, Francisco X. Real and Eduard Batlle Nature Cell Biology (2014) Doi: 10.1038 / ncb2992

Hypoxia - induced Jagged2 promotes breast cancer metastasis and self - renewal of cancer stem - like cells

Next, because KLF4 is involved in self - renewal of stem cell, we also examined the effect of both miR - 7 and KLF4 on proliferation of CSCs by MTS assay and found that miR - 7 was capable of blocking the growth of CSCs, whereas ectopic expression of KLF4 significantly mitigated this effect of miR - 7 (Fig. 4C).

The scientists have discovered that the colon has a safety mechanism to prevent the self - renewal of adenoma stem cells (Image: Colorectal Cancer Lab, IRB Barcelona)

Phenotypic stability and unlimited self - renewal capacity of cell derived from pluripotent stem cells are essential properties for cell assay development for High Throughput Screening (HTS) strategies.

Both microRNA families have the connection to drug resistance as well as to cancer stem cells, sub-population of cancer cells that have self - renewal properties and the ability to give rise to new tumors that are more resistant to current therapy.

The software the Microsoft team then built generated billions of possible models that could explain stem cell self - renewal.

In parallel, the roles of symmetric and asymmetric cell divisions are investigated as a mechanism for governing stem cell self - renewal and differentiation during embryonic development and in the adult.

Sophia Millonigg (Eckmann, MPG)-- «The translational activator complex GLD - 4 / GLS - 1 regulates germline stem cell self - renewal and differentiation in the adult C. elegans germ line» (2013)

Synthetic peptide - acrylate surfaces for long - term self - renewal and cardiomyocyte differentiation of human embryonic stem cells.