Sentences with phrase «stem cell signaling pathway»

Not exact matches

He conducted his postdoctoral research at Brigham and Women's Hospital / Harvard Medical School, where he researched the role of the Wnt signaling pathway in mouse models of kidney disease, and was part of a team that discovered a stem cell subtype responsible for solid organ fibrosis.

The team's next step is to zoom in on the molecular mechanisms that control how the Wnt signaling pathway interacts with the nail stem cells to influence bone and nail growth.

Researchers at Boston University School of Medicine (BUSM), under the direction of Sam Thiagalingam, PhD, found that a protein secreted by BLBC cells, called periostin (POSTN), acted to nurture and support cancer stem cells by activating a distinct signaling pathway in these cells.

To unravel the complex signaling pathway map, the scientists used their own findings from the analysis of factors regulated up or down in the interplay between tissue and stem cells, linking them with the signaling pathways described in existing literature.

This enabled adipose - derived adult stem cells to be successfully converted into mature fat cells within the experiments, and the corresponding signalling pathway mTORC1 was also decoded.

Her research has recently shown that a signaling pathway dubbed «hedgehog» is important not only for normal development of stem cells but also for the growth of cancer cells in chronic myelogenous leukemia.

She then followed up with a closer look at role of the Igf2 signaling pathway in coaxing quiescent hematopoietic stem cells to start dividing and maturing into multi-lineage progenitors that ultimately give rise to specialized blood cells.

They found that ONC201 alters the gene expression of cancer stem cell markers and signaling pathways prior to killing the tumor cells, providing pharmacodynamic biomarkers of response.

Scientists study the germline of the roundworm Caenorhabditis elegans to identify the mechanisms that control stem cell proliferation and homeostasis, as well as to advance our molecular understanding of homologous signaling pathways humans.

«Our results with Drosophila exhibit surprising similarities in some respects to what we know about the regulation of resting phases in mammals, allowing for speculation as to whether the Hippo signaling pathway in neural stem cells functions in the same manner in both vertebrates and invertebrates,» stated the paper's first author Rouven Ding.

Protein interactions between niche glial cells and the stem cells activate the Hippo signaling pathway in the stem cells to repress growth and cell division.

The Hippo signaling pathway, which is highly conserved up to humans, was known to play a critical role in organ size determination, like, for example, in the liver, but has not been demonstrated to influence neural stem cells in the central nervous system.

The final component in this long series of signal sequences is the Yorkie effector protein that is the decisive factor at the end of the Hippo signaling pathway and determines the start of reactivation, growth, and division in the stem cells.

Jasper says TOR can be regulated by a number of stimuli, and researchers are now attempting to better understand how the activity of this signaling pathway is controlled in stem cells.

«There has been a lot of work on Wnt signaling pathways, for example, so there are a lot of small - molecule drugs that could be tested to trigger a stem cell to mature into a neuron.»

The Wnt / β - catenin signaling pathway and microRNA 335 are instrumental in helping form differentiated progenitor cells from stem cells.

Professor Heiko Lickert, director of the IDR, in collaboration with Professor Gunnar Schotta of LMU München, showed that the Wnt / β - catenin signaling pathway regulates Sox17, which in turn regulates molecular programs that assign pluripotent cells to the endoderm, thus inducing an initial differentiation of the stem cells.

However, her research group has not yet identified how to make stem cells yield entirely dI1 or entirely dI3 cells — perhaps because another signaling pathway is involved, she said.

It locks onto and deactivates a protein, Smoothened, that activates the Hedgehog signaling pathway, which orchestrates how embryonic stem cells develop.

Interestingly, a previous STEM CELLS study from Janeczek et al. [3] established that activating the WNT signaling «pathway in BM led to the generation of an osteogenically enhanced subset of stem ceSTEM CELLS study from Janeczek et al. [3] established that activating the WNT signaling «pathway in BM led to the generation of an osteogenically enhanced subset of stem cCELLS study from Janeczek et al. [3] established that activating the WNT signaling «pathway in BM led to the generation of an osteogenically enhanced subset of stem cestem cellscells.

The Wnt, Shh, BMP, Insulin / IGF, and FGF signaling pathways have all been implicated in establishing and maintaining the adult retinal stem cell niche (reviewed in [34]--[37]-RRB-.

A new study describes an improved protocol for the efficient differentiation of endothelial cells from pluripotent stem cell sources and highlights the importance of the MAPK and PI3K signaling pathways

Integration of external signaling pathways with the core transcriptional network in embryonic stem cells.

Nonautonomous regulation of Drosophila midgut stem cell proliferation by the insulin - signaling pathway.

Adenoma (benign tumour) formation - driven by mutational activation of the Wnt signalling pathway in intestinal stem cells

Orai1 mediates osteogenic differentiation via BMP signaling pathway in bone marrow mesenchymal stem cells.

Niclosamide, an old antihelminthic agent, demonstrates antitumor activity by blocking multiple signaling pathways of cancer stem cells.

Fernando Ugarte Verdugo (Roesen - Wolff, TUD)-- «Role of Notch signalling pathway in human mesenchymal stem cell differentiation» (2009)

We use neuronal cultures, induced pluripotent stem (iPS) cells and transgenic and gene - targeted mouse models to study the differential effects of apoE3 and apoE4 on cell signaling pathways and cytoskelatal structure and function at molecular, cellular and behavioral levels.

The hematopoietic stem cell polarization and migration: A dynamic link between RhoA signaling pathway, microtubule network and ganglioside - based membrane microdomains.

They describe current attempts to isolate the totipotent cells found in stem cell cultures, which involve manipulating gene networks or intercellular signaling pathways.

Researchers investigating signaling pathways which control pluripotency highlight newly found interactions and redundancies in mouse embryonic stem cells

Anne Meyer (Reichmann, TUD)-- «Intracellular signaling pathways in the dopaminergic specification of fetal mesencephalic neural stem cells» (2009)

Numerous studies have demonstrated activity of these agents against a wide variety of cancers, especially cancer stem cell - like subpopulations, by a host of different mechanisms which comprise inhibition of signaling pathways, of mitochondrial respiration, as well as of cellular stress responses and others.

PNAS June 2009), and he is currently determining the key signalling pathways that mediate lung stem cell growth, quiescence and differentiation.

Although triple negative cancer cells lack the three critical genetic markers that are currently used to guide breast cancer treatment, the scientists» analysis suggests a strong reliance on signaling through pathways similar to those that affect fetal breast stem cell growth.

While studying a rare genetic disease, researchers discovered a signaling pathway linked to the efficiency of reprogramming somatic cells into stem cells.

Examples of these include cell proliferation, intracellular targeting, cell polarity, membrane traffic, cell migration, stem cell biology, chromatin regulation and function, differentiation, morphogenesis and biomechanics, and regeneration and cellular homeostasis, as well as developmental roles of genes, cellular structural dynamics, and signaling pathways.

Angiopoietin - Like 4 Confers Resistance to Hypoxia / Serum Deprivation - Induced Apoptosis through PI3K / Akt and ERK1 / 2 Signaling Pathways in Mesenchymal Stem Cells

Inhibition of Notch signaling reduces proliferation of stem cells, induces cell death, and down - regulates non-canonical Wnt5a, suggesting that the Notch pathway contributes to maintenance and motility of the stem cells.

Titles: 1) Angiopoietin - Like 4 Confers Resistance to Hypoxia / Serum Deprivation - Induced Apoptosis through PI3K / Akt and ERK1 / 2 Signaling Pathways in Mesenchymal Stem Cells

We have shown that cyclic activation of the Wnt / b - catenin signalling pathway enhances cell - fusion - mediated reprogramming of a variety of somatic cells (Lluis et al., Cell Stem Cell 2008, Marucci et cell - fusion - mediated reprogramming of a variety of somatic cells (Lluis et al., Cell Stem Cell 2008, Marucci et Cell Stem Cell 2008, Marucci et Cell 2008, Marucci et al..

Researchers discover a new regulatory pathway that channels signals emanating from a plant's extremities to the stem cell niche...

The Ellerby lab is known for its pioneering studies on Huntington's disease (HD), and Karen is now using human stem cell models of HD to understand why important molecular signaling pathways, such as the TGF - β pathway, are dysregulated in HD.

Both Notch and p53 signalling are implicated in stem cell self - renewal (18, 19), and the endocytic protein Numb is connected to both these signalling pathways.

Our work indicates that only a small fraction of the population resides at the top of the hierarchy, that lineage priming (co-expression of stem cell and lineage specific genes) characterizes pluripotent stem cell populations, and that extrinsic signaling pathways are upstream of transcription factor networks that control pluripotency.

Development of cartilage tissue from mesenchymal stem / stromal cells after eight weeks in vivo: Inhibition of the signaling pathway of the protein BMP leads to the maintenance of stable cartilage tissue, indicated by red staining (left).

Cortical development and cortical stem cells The laboratory uses neural stem cell culture, transgenic model systems and retroviral vectors to study signalling pathways that are central in mouse cortical development and in particular in cortical stem cells.

Because miR - 142 is upregulated in the BCSCs and stimulates the canonical WNT signaling pathway that is an important regulator of the stem cell properties in mammary tissues, we tested the ability of miR - 142 to regulate the organoid formation of BCSCs.