Sentences with phrase «stem cell stage»

This process is much faster than generating mice with mutations inserted at the embryonic stem cell stage, which can take a year or longer.

Other researchers have bypassed the pluripotent stem cell stage while turning skin cells into neurons and other specialized cells, Zhang acknowledges, but the new research, just published in Cell Reports, had a different goal.

Su - chun Zhang and his colleagues at the University of Wisconsin, Madison, and the University of Bonn, Germany, directed the development of embryonic stem cells stage by stage, using the same growth factors the body uses.

«Adult cells transformed into early - stage nerve cells, bypassing the pluripotent stem cell stage.»

They discovered that extra chromosome 21 - a genetic state known as trisomy 21 - disturbs a key regulating gene called NRSF or REST, which in turn disturbs the cascade of other genes that control normal development at the embryonic stem cell stage.

The method allows skin cells to bypass the stem cell stage as they are being reprogrammed into neurons.

Passing through a stem cell stage resets the developmental clock to an embryonic - like state, wiping out the age - associated effects of the disorder.

Skipping the stem cell stage would be more efficient, says Andrew Yoo of Washington University in St Louis, Missouri, who has turned skin cells into medium spiny neurons (MSNs), the cells that go wrong in Huntington's disease.

In their previous work, Bursac and his team started with small samples of human cells obtained from muscle biopsies, called «myoblasts,» that had already progressed beyond the stem cell stage but hadn't yet become mature muscle fibers.

Another team, from Stanford University, converted human skin cells directly into neurons without first stopping at the stem cell stage, potentially making the process more efficient.

In this method, skin cells are turned directly into brain, heart, liver, or pancreas cells without going through a stem cell stage first.

Changes affecting the GATA1 transcription factor, a key regulator of red blood cell formation, were evident even at the stem cell stage of development.

We recently discovered that by introducing just three genes that nature uses to make heart cells in an embryo, we could convert fibroblasts directly into heart muscle cells in a lab dish, skipping the stem cell stage entirely and going straight from fibroblasts to beating heart cells.

It means taking readily available cells, such as skin cells or blood cells, and converting them into cells that researchers want for therapeutic purposes, skipping the stem cell stage.