Sentences with phrase «stem cell state»

Using now - standard techniques, they put those cells through a biological time machine, returning them to an embryo - like stem cell state.

«We've not had cell surface markers for the different stem cell states before, which has made it hard to study them,» says Fredrik Lanner, assistant professor at Karolinska Institutet's Department of Clinical Science, Intervention and Technology.

Ecker, working closely with Jaenisch and other collaborators at Whitehead and the Ecole Polytechnique Federale de Lausanne, wanted to see whether these new techniques aiming to induce the naïve stem cell state truly did that.

«But it appears when mature cells return back into a rapidly dividing stem cell state, this creates problems that can lead to cancer.»

- Our results provide new insights into the mechanisms of how POLR3G gene regulates stem cell state, which in turn sheds light on the complex mechanisms with which human embryonic stem cells both self - renew and maintain the ability to differentiate.

The ability of a fertilized egg to generate both embryonic and extra-embryonic tissues is referred to as «totipotency,» an ultimate stem cell state seen only during the earliest stages of embryonic development.

Other research in this area has required that cells of one type first be returned to a more generally undifferentiated stem cell state, which can introduce fresh problems.

«Molecular roadmap of human stem cell states.»

Ultimately, this knowledge will be useful for understanding the very early events in human development, which are reflected in the naïve and primed stem cell states, and could also lead to improved methods to reprogram human cells for stem cell - based therapies.

In the case of gene editing, Verma is creating induced pluripotent stem cells (iPSCs) from patients by taking, for example, skin cells of patients, coaxing them back into an early stem cell state, and then providing conditions to make those cells develop into more complex brain, lung, prostate and breast tissues.

Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast.

Our research will uncover important molecular pathways that modulate Tumor propagating cell number and the plasticity of the cancer stem cell state.

Past attempts by other teams to restore pluripotency to mouse cells from the epiblast stem cell state have yielded far lower amounts, or non-viable cells.

Johns Hopkins scientists have developed a reliable method to restore blood cells into a primitive stem cell state from which...

With this method, the cells don't have to be taken all the way back to a pluripotent stem cell state, meaning the scientists can turn them into pancreatic cells faster.

Further reprogramming was required to establish a mature naïve cell, and we could associate this process with the activation of the previously silent X chromosome and to the increased activity of other genes that define the naïve stem cell state.

Stiffer surfaces favored the stem cell state.

Even without stem cells, the mice developed a precancerous condition because mature stomach cells reverted back to a stem cell state to heal the injury.

Instead of using viruses to deliver a gene package to the cells to turn on processes that convert the cells back to stem cell states, Zambidis and his team used plasmids, rings of DNA that replicate briefly inside cells and then degrade.

If we could get cancer stem cells to abandon their stem cell state, they would no longer have the power to keep repopulating tumors,» says Semenza, who also directs the Vascular Biology Research Program at the Institute for Cell Engineering.

Semenza says methylation leads to the destruction of NANOG's mRNA so that no protein is made, which in turn causes the embryonic stem cells to abandon their stem cell state and mature into different cell types.

«We found that the beginning of cancer occurs after activation of an oncogene or loss of a tumor suppressor, and involves a change that takes a single cell back to a stem cell state.»

Fredrik Lanner's research team at Karolinska Institutet and their colleagues in Peter Rugg - Gunn's team at Cambridge's Babraham Institute in the UK have now developed a tool for separating the two stem cell states.

All - Protein Mix Inducing adult cells to revert back to a stem cell state at first required the insertion of four genes, one of which was a cancer gene [see «Potent Alternative»; SciAm, February 2008].

He's new study not only reveals a novel mechanism regulating the «totipotent - like» stem cell state, but also provides a powerful cell - culture system to further study totipotency.

And importantly, avoiding a stem cell state allows the resulting motor neurons to retain the age of the original skin cells and, therefore, the age of the patient.

In new research, scientists at Washington University School of Medicine in St. Louis have converted skin cells from healthy adults directly into motor neurons without going through a stem cell state.

By tapping into this newly identified connection, we open up new avenues for more successful reprogramming of adult cells to a stem cell state, which is a priority for future regenerative medicine approaches.»

The team then asked this minimal model set to predict whether knockdown of a specific transcription factor would maintain the stem cell state or prompt differentiation.

«We wanted to understand how stem cell transcription factors were interconnected and explain how these cells behave in different culture conditions and still maintain the stem cell state,» said Smith.

Just a few kinds of signals control the fates of cells that either maintain their stem cell state, divide or differentiate in a developing organism.

Maintaining the stem cell state for many months in the lab does not reflect what happens during normal embryonic development where it exists only transiently.

Rather than reversing cells all the way back to a stem cell state before prompting them to turn into something else, such as in the case of iPS cells, the researchers «rewind» skin cells just enough to instruct them to form the more than 200 cell types that constitute the human body.

In doing so, they also found the first evidence that unrelated adult cells can be reprogrammed from one cell type to another without having to go all the way back to a stem cell state.

However, direct cellular reprogramming that does not involve a stem cell state solves some of the safety concerns surrounding the use of stem cells.

Direct reprogramming could revolutionize the field of regenerative medicine, as it lets scientists transform one adult cell type into another without first having to revert back to the stem cell state.

Melton is also a pioneer in direct cellular reprogramming research — the transformation of one type of adult cell into another, without first going through a stem cell state.

His breakthrough technique, first published in 2006, uses four proteins (called the Yamanaka factors) to convert skin cells back to a pluripotent stem cell state.

Role of SAGA, a histone acetylase complex, in reprogramming fibroblasts to a stem cell state defined (4/15/15) A collaboration between Dr. Sharon Dent and Dr. Jeff Wrana at the Lunenfeld - Tanenbaum Research Institute, has shown that Myc drives expression of the SAGA component Gcn5.

Together, Myc and Gcn5, a histone acetyltransferase, reprogram fibroblasts to a stem cell state by activating an alternative splicing network.

This form, known as the stem cell state, is the point at which blood cells may develop into any other type of cell in the body.

In 2010, Srivastava and a former postdoctoral fellow, Masaki Ieda, PhD, expanded on that breakthrough with direct reprogramming in a dish, which allows scientists to transform one adult cell type into another without first reverting back to a stem cell state.