Sentences with phrase «stem cell subpopulation»

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«We have identified a code of «molecular switches» that control a very aggressive subpopulation of brain cancer cells, so - called glioblastoma stem cells,» says Mario Suvà, MD, PhD, of the MGH Department of Pathology and Center for Cancer Research, co-lead author of the Cell article.

They identified a subpopulation of glioma stem cells, which, unlike most glioma cells, did not accumulate substantial amounts of fluorescent product during photodynamic detection.

To investigate this hypothesis, the scientists focused on how a subpopulation of mouse intestinal stem cells responded under calorie restriction and then when the animals were exposed to radiation.

Developmental biologist Goro Yoshizaki of Tokyo University of Marine Science and Technology in Japan and his colleagues set out to see whether spermatogonia — male germ cells that give rise to sperm — might contain a subpopulation of cells with stem cell - like activity that can develop into either sperm or eggs.

Sphere - forming cell subpopulations with cancer stem cell properties in human hepatoma cell lines.

Within tumors, there exists a subpopulation called the «cancer stem cells» (CSCs).

Characterization of multipotent adult progenitor cells, a subpopulation of mesenchymal stem cells.

Numerous studies have demonstrated activity of these agents against a wide variety of cancers, especially cancer stem cell - like subpopulations, by a host of different mechanisms which comprise inhibition of signaling pathways, of mitochondrial respiration, as well as of cellular stress responses and others.

Colter DC, Sekiya I, and Prockop DJ Identification of a subpopulation of rapidly self - renewing and multipotential adult stem cells in colonies of human marrow stromal cells.

Here, we show that a non-adherent, stem - like, and metastatic CSC - enriched subpopulation could be isolated by exposing human metastatic breast cancer cell lines to cycles of chronic hypoxia followed by reoxygenation.

Together, our results reinforce the idea that EMT and stem cell factors work cooperatively in highly tumorigenic cancer subpopulations and raise interesting questions about their contribution to the increased metastatic capability observed in the cycling hypoxia - selected subpopulation.

In our study, we found that exposing metastatic breast cancer cell lines to hypoxia and reoxygenation cycles induces a unique subpopulation that is highly metastatic and exhibits stem - like and EMT phenotypes.

Recent studies have described a subpopulation of cancer cells within tumors termed «cancer stem cells» (CSCs), which have stem - like properties such as self - renewal and the ability to differentiate into multiple cancer cell types [1 — 7].

Proliferation Drives Aging - Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

Title: A Subpopulation of Adult Skeletal Muscle Stem Cells Retains All Template DNA Strands after Cell Division Authors: Rocheteau P, Gayraud - Morel B, Siegl - Cachedenier I, Blasco MA, Tajbakhsh S Date: January 2012 Publication Details: Cell.

In our study, we found that the emergence of a small non-adherent subpopulation (approximately 1 %) survived after the first hypoxia / reoxygenation cycle and speculate that cyclic exposures of hypoxia and reoxygenation may select for the stem - like subpopulation with the ability to overcome replication arrest whereas the majority of non-adherent cells can not.

Stem cell transplants (SCT) can elicit long - term disease free survival, but this treatment presents risks for the largest subpopulation of AML patients, the elderly.

Furthermore, we found that the stem - like and EMT phenotypes observed in the cycling hypoxia - selected subpopulation are not reversible, because we obtained the same molecular profile from this subpopulation by culturing them as spherical cultures for several months in normal oxygen content and culturing them as adherent cells (Figure S2 in Additional file 2).

We also found that cells derived from this novel subpopulation form colonies readily, are highly tumorigenic in immune - deficient mice, and exhibit both stem - like and EMT phenotypes.

Recent studies have described a subpopulation of cancer stem cells (CSC) within tumors, which have stem - like properties such as self - renewal and the ability to differentiate into multiple cell types.

Our results led us to speculate that there might be a metastatic subpopulation within stem - like cancer cells since other studies have shown that CSC phenotype alone may exhibit invasive property in vitro but is inadequate to determine or predict in vivo metastasis.

A unique focus of my work is on the impact of heterogeneity within tumors and tumor cell populations, including subpopulations commonly referred to as «cancer stem cells», on the immune response.

In previous studies, TERT - / - mice have been generated on either a C57BL / 6J or a 129 / C57BL / 6J mixed genetic background strain, both of which have «very heterogeneous and unusually long telomeres,» again raising the possibility that any developmental abnormalities might be due to subpopulations of stem cells with critically - short telomeres.

We hypothesize that SSEA3 expression is either identifying another less differentiated and / or tissue specific stem cell like population that is retrieved with the donor skin biopsy or that with culture, a subpopulation of fibroblasts may acquire the ability to express SSEA3.

Citation: Byrne JA, Nguyen HN, Reijo Pera RA (2009) Enhanced Generation of Induced Pluripotent Stem Cells from a Subpopulation of Human Fibroblasts.

Single - cell transcriptomics on pluripotent stem cells has provided new insights into cellular variation, subpopulation structures and the interplay of cell cycle with pluripotency.

Glioma stem cells (GSCs) are a subpopulation of cells that contribute to tumor progression.

Cancer stem cells (CSCs) known as tumorigenic cells are biologically distinct from diverse subpopulations.

Using single - cell transcriptomics, we identified a distinct subpopulation of old HSCs carrying a p53 signature indicative of stem cell decline alongside pro-proliferative JAK / STAT signaling.