Sentences with phrase «stem cell targeting»
In order for stem cell targeting of antibodies to be clinically relevant, immunoglobulin - secreting NSCs must retain their migratory tumor - tropic properties.
http://journals.plos.org/ Not exact matches
One recent example: Stemcentrx, which rode an unproven approach targeting cancer stem cells to a summertime financing round of nearly $ 250 million and a $ 5 billion valuation, the most for a venture - backed drug maker and second to Theranos in health care.
Many scientists believe that targeting a type of cell called a cancer stem cell may be necessary to completely cure lung cancer.
«Several unusual nucleobases have been found in the genomes of stem cells, which are produced by targeted chemical modification of the known building blocks of DNA.
«Several major advances in recent years have been good news for multiple myeloma patients, but those new drugs only target terminally differentiated cancer cells and thus can only reduce the bulk of the tumor,» said Jamieson, who is also deputy director of the Sanford Stem Cell Clinical Center, director of the CIRM Alpha Stem Cell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego HeaStem Cell Clinical Center, director of the CIRM Alpha Stem Cell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego HeaCell Clinical Center, director of the CIRM Alpha Stem Cell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego HeaStem Cell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego HeaCell Clinic at UC San Diego and director of stem cell research at Moores Cancer Center at UC San Diego Heastem cell research at Moores Cancer Center at UC San Diego Heacell research at Moores Cancer Center at UC San Diego Health.
If we can learn lessons from Zika's ability to cross the blood - brain barrier and target brain stem cells selectively, we could be holding the key to future treatments.»
To hunt for drugs that target these cells, Piyush Gupta, a molecular biologist at the Broad Institute at the Massachusetts Institute of Technology, and colleagues genetically engineered ordinary human cells so that they acquired some of the properties of cancer stem cells, including being impervious to chemotherapy.
This early stage research will explore how the virus targets stem cells and provide the starting point to develop new treatments that seek out the tumour and spare the surrounding healthy brain tissue.
Our work suggests that targeting a specific stem cell phenotype, for example with immunotherapies, could be beneficial in patients with oligodendroglioma.»
«Our work strongly supports that cancer stem cells are the main source of growth in these tumors and, as such, should be considered promising targets for treatment,» says Mario Suvà, MD, PhD, of the MGH Department of Pathology, co-senior author of the Nature paper.
Targeting exhausted immune cells may change the prognosis for patients with acute myeloid leukemia (AML) relapse after a stem cell transplant, according to Penn State College of Medicine researchers.
The current study was designed to clarify the cellular hierarchy underlying glioblastoma, to identify epigenetic factors that distinguish glioblastoma stem cells from more differentiated tumor cells and to suggest potential therapies targeting those factors.
Dr Michael P. Lisanti, Professor of Translational Medicine at the University of Salford, said: «We have been looking at how to target cancer stem cells with a range of natural substances including silibinin (milk thistle) and CAPE, a honey - bee derivative, but by far the most exciting are the results with Vitamin C.
«Results in Phase I trial targeting cancer stem cells.»
«These are optimistic results for one of the first targeted therapies for cancer stem cells,» says Antonio Jimeno, MD, PhD, investigator at the CU Cancer Center, director of the university's Cancer Stem Cell - Directed Clinical Trials Program, and principal investigator of the clinical trial at the CU Cancer Center sstem cells,» says Antonio Jimeno, MD, PhD, investigator at the CU Cancer Center, director of the university's Cancer Stem Cell - Directed Clinical Trials Program, and principal investigator of the clinical trial at the CU Cancer Center sStem Cell - Directed Clinical Trials Program, and principal investigator of the clinical trial at the CU Cancer Center site.
Cardiff University scientists have developed a novel anti-cancer stem cell agent capable of targeting aggressive tumour forming cells common to breast, pancreas, colon and prostate cancers.
In a study recently published in the journal Nature Biotechnology, HSCI researchers at Harvard University and Massachusetts General Hospital (MGH), in collaboration with Boston Children's Hospital and Dana Farber Cancer Institute, have developed a non-toxic transplantation procedure using antibodies to specifically target blood stem cells in mice, an approach they hope will make blood stem cell transplants for these patients far less toxic.
The drug that they have developed appears to target cancer stem cell activity, which suggests it will prevent metastatic recurrence and be useful in combatting drug resistance.»
Using the same computer - based approach, the team has now been able to target the c - FLIP (cellular FLICE [FADD - like IL - 1β - converting enzyme]- inhibitory) protein, known to play a key role in cancer stem cell maintenance and survival, described in previously published work by the Institute.
Until last year, public investment in stem cells in South Korea was relatively low and targeted mainly at basic research.
«In order to block tumor recurrence after radiation therapy, we used an antibody to target and inhibit these cancer stem cells,» said Dr. Xu.
Joseph Wu of Stanford University, California, and his team have found that a mouse's immune system can be primed to recognise and target cancer cells by vaccinating them beforehand with stem cells.
«Viral infection in colon cancer stem cells mimicked; druggable target identified.»
«But in the future we might be able to use this technique therapeutically, for example to directly target and correct a mutation in muscle stem cells and muscle fibers.»
Researchers targeting colorectal cancer stem cells — the root cause of disease, resistance to treatment and relapse — have discovered a mechanism to mimic a virus and potentially trigger an immune response to fight the cancer like an infection.
Rare stem - like tumor cells play a critical role in the spread of breast cancer, but a vulnerability in the pathway that powers them offers a strategy to target these cells using existing drugs before metastatic disease occurs, report University of California San Diego School of Medicine and Moores Cancer Center researchers.
The next step is to start clinical trials to find out if targeting colon cancer stem cells in this way will result in durable cures.»
Based on a report published on August 20, 2015 in Nature Communications, it has been established that certain nutrients support CML stem cell activity in vivo, thus pointing towards a potential therapeutic target for CML therapy.
«The long - term vision is simple,» said Saif, who is also part of the Beckman Institute for Advanced Science and Technology at the U. of I. «Could we make elementary structures and seed them with stem cells that would differentiate into smart structures to deliver drugs, perform minimally invasive surgery or target cancer?»
«Inflammation is associated with bone growth: A study using induced pluripotent stem cells suggests that a molecule for inflammation could be a good drug target to prevent diseased bone growth.»
In mammary gland stem cells, for example, Numb binds and inhibits an enzyme called Mdm2, preventing it from targeting p53 for degradation.
«We are developing a fetal brain stem cell line to identify other fetal brain sugars that may be targets of Zika,» he adds.
What's more, they identified Cas as a critical, tissue - specific target of Hh signaling, which not only plays a key role in maintaining follicle stem cells but also assists in the diversification of their progeny.
«Microenvironment of hematopoietic stem cells can be a target for myeloproliferative disorders.»
Shah and his team induced toxin resistance in human neural stem cells and subsequently engineered them to produce targeted toxins.
These diets may naturally be providing a shotgun approach to cancer prevention by using a wide variety of beneficial compounds to target multiple pathways that cancer stem cells use to survive.
Today the brain's serotonin system is already a known target for the treatment of depression, and according to researchers it should be possible to use time signals in pharmaceutical development based on stem cells.
Previous studies have shown that a small molecule known as ONC201 currently in advanced cancer clinical trials, targets self - renewing colorectal cancer stem cells.
Other ongoing stem cell trials are targeting blood disorders like aplastic anemia, leukemia, lymphoma, and, of course, sickle - cell disease.
The team has shown that the microenvironment that controls hematopoietic stem cells can be targeted for the treatment of a set of disorders called myeloproliferative neoplasias, the most prominent of which are chronic myelomonocytic leukemia (CMML), juvenile myelomonocytic leukemia (JMML), and atypical chronic myelogenous leukemia (CML).
Researchers have been seeking a way to improve the body's ability to combat the virus by engineering blood - forming stem cells to specifically target and kill HIV - infected cells for the life of the individual.
This may contribute to the development of stem cell therapy targeted at other diseases.
Because HIV uses CD4 to infect cells, the researchers used a CAR molecule that hijacks the essential interaction between HIV and the cell surface molecule CD4 to make stem cell - derived T - cells target infected cells.
That's an important lesson, Tolar says; it suggests that future attempts to correct genetic skin diseases should focus on culture conditions that nourish these stem cells, and potentially even target them for modification.
A new study, however, provides insights on the cellular mechanisms that might be targeted to help certain stem cells - called human mesenchymal stem cells (hMSCs)- maintain properties needed to make them clinically useful.
Toward the goal of precisely augmenting telomerase activity selectively within adult stem cells, this discovery reveals the crucial step in telomerase catalytic cycle as an important new drug target.
«To have a therapy at our disposal that safely targets just the T cells causing graft - versus - host disease would represent a major step forward in stem cell transplantation.
But why does WOX5 switch off its target gene CDF4 in stem cells?
By specifically targeting the pause signal that prevents restarting DNA repeat synthesis, telomerase enzymatic function can be supercharged to better stave off telomere length reduction, with the potential to rejuvenate aging human adult stem cells.
«As we make improvements to our toolbox of agents capable of achieving this Holy Grail of stem cell transplant, it's essential to include targeted approaches like abatacept.»