Coming from the Georgia Institute of Technology, Dr. McDevitt's expertise in biomedical engineering will be a unique contribution to Gladstone, providing insight into
stem cell tissue engineering and how to best leverage this technology into tangible therapeutic options.
Telomerase activity has been considered to be a marker for stem cells [23], but it is not found in
all stem cell tissues [24].
Not exact matches
Animal
cells are cultured from
stem cells and incubated in a «bioreactor» into
tissue that can be «harvested» and formed into familiar foods like meatballs, patties, and fish sticks.
For example, using 3 - D bioprinters — which can print the structure of human
tissue with biodegradable material — and
stem cells, which are used to populate the 3 - D printed structure, researchers can grow actually human
tissue.
The new
tissue wasn't rejected since they
stemmed from the mice's
cells in the first place.
A research group at Cincinnati Children's Hospital Medical Center used human pluripotent
stem cells (hPSCs) to grow human stomach
tissue (paywall)-- and, notably, the part of the organ that produces digestive enzymes.
Drawing on Toronto's leading
stem cell and
tissue engineering expertise, one group will focus on new models for repairing damaged hearts.
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Stem Cell, Amniotic
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According to Science Daily, Dr. Nagy, senior investigator at the Samuel Lunenfeld Research Institute of Mount Sinai Hospital, there is a «new method of generating
stem cells that does not require embryos as starting points and could be used to generate
cells from many adult
tissues such as a patient's own skin
cells.»
A seriously ill person in need of embryonic
stem cells to repair damaged
tissue.
«Scientists say they have replaced a 65 - year - old patient's upper jaw with a bone transplant cultivated from
stem cells isolated from his own fatty
tissue and grown inside his abdomen.»
The NIH defines totipotent
cells as the source of both embryonic
stem cells and of trophoblast
cells which give rise to extra-embryonic
tissues such as the placenta.
The difficulties associated with obtaining nerve
tissue at the correct stage of development and differentiation from aborted embryos means that foetal
tissue transplantation is no longer in favour, but the creation of human embryos specifically as sources of
stem cells, and the push to use «spare» embryos from IVF treatments is gatheringmomentum.
Scientists looking for new methods to make human
tissue have successfully used cloning technology to create embryonic
stem cells from skin
cells.
Whilst acknowledging that many questions remain unanswered in the debate between those who would advocate the use of
stem cells taken from human embryos, and those experimenting on
stem cells drawn from
tissues of the adult human body, there is a lengthy discussion of the moral status of the human embryo as being a crucial matter in this regard.
Cord
tissue is a small segment of the baby's umbilical cord, which is a rich source of different
stem cells not found in cord blood
Stem cell preservation is proving advantageous, as more and more parents elect to harvest their children's umbilical cord blood and cord
tissue.
It's a rich source of
stem cells, particularly those that can grow into
tissues, organs, and blood vessels.
Stem cell research and diabetes
Stem cell research is a relatively new area of investigation, believed by many in the scientific and medical communities to have important new potential for the treatment of many diseases and conditions particularly those like diabetes, which are characterised by severe damage to certain
cells and
tissues..
As well as allowing the use of
stem cells grown from established
cell lines, the technology could enable the creation of improved human
tissue models for drug testing and potentially even purpose - built replacement organs.
Lab - grown
tissues derived from patients»
stem cells may also allow researchers to screen drugs and test their effectiveness on diseases like cancer.
From the embryonic
stem cells, the researchers produced a type of
tissue called retinal pigment epithelium (RPE).
Scientists have long speculated that astrocytes, the
cell type that controls many neuronal functions, give rise to neural
stem cells in damaged brain
tissue.
In a study in the journal Science, researchers explain how they used mouse embryonic
stem cells and microchip technology to create heart muscle
tissue that actually beats.
On Thursday, the United Nations» member states will consider two resolutions: One resolution would ban all human cloning methods, including efforts to use cloned embryonic
stem cells to try and generate healthy
tissues, or to treat degenerative diseases such as Parkinson's.
Stomach switch The key to turning pluripotent
stem cells into stomach
cells was a pathway of interactions that acts as a switch between growing
tissues in the intestine and in the antrum, a part of the stomach near its outlet to the small intestine.
Da Cruz and his team grew replacement RPE
cells from human embryonic
stem cells on a thin plastic scaffold, before transplanting the
tissue into the back of each volunteer's eye.
Tiny balls of brain
tissue made from donated
stem cells from children with autism or a condition that makes them hyper - sociable show intriguing differences
To develop their «disease in a dish» model, the team took skin
cells from patients with Allan - Herndon - Dudley syndrome and reprogrammed them into induced pluripotent
stem cells, which then can be developed into any type of
tissue in the body.
Two people with severe sight loss can now see well enough to read after receiving
tissue grown from human embryonic
stem cells.
International
Stem Cell scientists have converted them into liver
cells and plan to convert them into neurons for treating Parkinson's disease, pancreatic
cells for diabetes, and other
tissues.
Balls of brain
tissue generated from
stem cells are enabling us to understand the underlying differences between people who struggle to be sociable and those who have difficulty reining themselves in.
Stem cells in babies» urine seem to help regenerate kidney
tissue, protecting it from toxic drugs and could pep up organs for transplantation
Orwig says there are some concerns that implanting
stem cells could reintroduce cancer
cells that may have been present in the original
tissue.
«During the development of specialized
tissues from
stem cells, enzymes belonging to the Tet family also oxidize the thymidine base, as we have now shown with the aid of highly sensitive analytical methods based on mass spectrometry.
A detour on the road to regenerative medicine for people with muscular disorders is figuring out how to coax muscle
stem cells to fuse together and form functioning skeletal muscle
tissues.
The discovery is an important advance in the search for new medications to fight obesity, said senior investigator Shingo Kajimura, PhD, UCSF assistant professor of
cell and tissue biology, with a joint appointment in the UCSF Diabetes Center and the Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research at U
cell and
tissue biology, with a joint appointment in the UCSF Diabetes Center and the Eli and Edythe Broad Center of Regeneration Medicine and
Stem Cell Research at U
Cell Research at UCSF.
Beginning in the 1970s, physicians learned how to harvest skin
stem cells from a patient with extensive burn wounds, grow them in the laboratory, then apply the lab - grown
tissue to close and protect a patient's wounds.
«It was particularly exciting to observe that the repair of the skin epidermis involves the activation of very different
stem cells that react the same way to the emergency situation of the wound and have the power to completely restore the damaged
tissue», comments Mariaceleste Aragona, the first author of the study.
They found 60 per cent fewer blood vessels surrounding tumour - like
tissue grown from Down's
stem cells than those from other volunteers.
However, centres in the US and Europe are already banking testicular
tissue for boys in the hope that new
stem -
cell - based therapies will become available.
With the help of
stem cell technology, we are learning to make
tissues from scratch.
Adenovirus 36 has been found to encourage the transformation of adult
stem cells in fatty
tissue into fat
cells as discussed on the daily Scientific American podcast 60 - Second Science on August 20th.
In past projects, scientists have tried to derive various types of differentiated
cells from
stem cells — such as bone,
tissue, nerves or fat — directly from hiPSCs.
Stem cells have the potential to repair most
tissues in the body.
This may be one of the most important facets of studying regeneration in these animals because they provide a completely different approach to
tissue regeneration than that offered by
stem cells.
One of the key questions in biology is to identify how
tissues are repaired after trauma and understand how
stem cells migrate, proliferate, and differentiate to repair
tissue damage.
Then, to boost the number of
cells, which is another hurdle in
tissue engineering, the researchers mixed the chondrocytes with human mesenchymal
stem cells from bone marrow.
In lab dishes, the blast
cells formed
tissues that resembled blood - forming
stem cells as well as blood vessels, the group found.
What's more, when ordinary colon cancer
cells were implanted near connective
tissue in other mice, they transformed into cancer
stem cells (Nature
Cell Biology, DOI: 10.1038 / ncb2048).