Sentences with phrase «stem cells by»

In the research world, controversial stem cell studies have been retracted from the prestigious journal Nature, in which Japanese and US scientists claimed to have reprogrammed stem cells by exposing them to acid.

The major discovery of embryonic stem cells by Martin Evans in 1981 has indeed been recognized by a Lasker and other awards.

Review of «Production of gene - corrected adult beta globin protein in human erythrocytes differentiated from patient iPSCs after genome editing of the sickle point mutation» from Stem Cells by Stuart P. Atkinson

LA JOLLA — Salk scientists and collaborators have shed light on a longstanding question about what leads to variation in stem cells by comparing induced pluripotent stem cells (iPSCs) derived from identical twins.

Here, authors from Corning Life Sciences describe dissolvable microcarriers as a scalable solution for large - scale expansion and harvest of functional human mesenchymal stem cells by enabling simplified downstream processing and high - yield cell recovery.

Here we characterise Myst2 / Kat7 / Hbo1 protein interactions in mouse embryonic stem cells by affinity purification coupled to mass spectrometry.

The legislation would allow scientists to create embryos for purposes of harvesting the stem cells by transferring human DNA into animal eggs that have had most of their genetic information removed.

The latest study, published in Cell Stem Cell, offers a third way to turn skin cells into stem cells by directly manipulating the cells» genome using CRISPR gene regulation techniques.

The Society believes that research involving the transfer of a human nucleus into an animal egg will lead to important new knowledge about cell nuclear replacement (CNR) technology and, if it were to prove possible to produce embryonic stem cells by this route, would increase understanding of how to programme these cells to develop into different tissue types.

Kirsten Obernier, PhD, a postdoctoral researcher in Alvarez - Buylla's lab, spent six years trying to understand how the brain avoids running out of neural stem cells by catching the cells in the act of dividing.

In a series of lab experiments with cell lines, human xenograft tumors in mice and primary human prostate cancer samples, the researchers demonstrated that miR - 34a inhibits prostate cancer stem cells by suppressing CD44.

Researchers use these receptors — or markers — to identify and isolate adult stem cells by «tagging» the chemical messages that bind to those specific receptors on the stem cell with fluorescent molecules.

Cardiac differentiation of embryonic stem cells by substrate immobilization of insulin - like growth factor binding protein 4 with elastin - like polypeptides.

This differentiation is triggered by the endogenous Notch inhibitor Numb, which is upregulated in the stem cells by Wnt7a derived from UV - irradiated keratinocytes.

Review of «Human adipose derived stromal / stem cells (hASCs) protect against STZ - induced hyperglycemia; analysis of hASC - derived paracrine effectors» from Stem Cells by Stuart P. Atkinson.

Review of «Induced Pluripotent Stem Cell - Derived Natural Killer Cells for Treatment of Ovarian Cancer» from Stem Cells by Stuart P. Atkinson

In 2012, Dr. Yamanaka was awarded the Nobel Prize in Physiology or Medicine for his discovery that skin cells can be reprogrammed into pluripotent stem cells by changing just four key genes.

Review of «A distinct DNA methylation signature defines breast cancer stem cells and predicts cancer outcome» from Stem Cells by Stuart P. Atkinson

CBR is dedicated to advancing the clinical application of cord blood and cord tissue stem cells by partnering with institutions to establish FDA - regulated clinical trials for conditions that have no cure today.

Review of «Biological markers of Mesenchymal Stromal Cells as Predictors of response to Autologous Stem Cell Transplantation in Patients with Amyotrophic Lateral Sclerosis; an Investigator - Initiated Trial and in Vivo Study» from Stem Cells by Stuart P. Atkinson

Review of «Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: A proof - of - concept clinical trial» from Stem Cells by Stuart P. Atkinson

Review of «Safety and efficacy of a tCD25 pre-selective combination anti-HIV lentiviral vector in human hematopoietic stem and progenitor cells» from Stem Cells by Stuart P. Atkinson

Title: Targeting leukemic stem cells by breaking their dormancy Authors: Essers MAG, Trumpp A Date: 2010 Publication Details: Molecular Oncology Volume 4, Issue 5, October 2010, Pages 443 — 450

The aorta - gonad - mesonephros (AGM) region in the aortic wall appears to be the most important source of new blood cells, and it has been found to contain numerous hematopoietic stem cells by day 11 of mouse embryonic development.

Review of «Continuous non-cell autonomous reprogramming to generate retinal ganglion cells for glaucomatous neuropathy» from Stem Cells by Stuart P. Atkinson

Researchers have developed a new technique for creating human embryonic stem cells by fusing adult somatic cells with embryonic stem cells.

Nicola Bauer (Corbeil, TUD)-- «New insights into the plasma membrane dynamics of rare stem cells by studying the prominin molecule» (2007)

Large - scale production of megakaryocytes from human pluripotent stem cells by chemically defined forward programming.

She ends the session on stem cells by describing the path to using stem cells in clinical trials.

In a scientific first, researchers at the Gladstone Institutes turned skin cells from mice into stem cells by activating a specific gene in the cells using CRISPR technology.

mRNA expression from the targeted allele could be detected in embryonic stem cells by RT - PCR (Figure 1D), although expression was reduced approximately 5-fold relative to wt mRNA transcript levels as determined by Northern blotting of RNA from the testis of heterozygous animals (Figure 1E).

Expansion of embryonic and adult neural stem cells by in utero electroporation or viral stereotaxic injection.

Currently, she is investigating how inhibiting aldehyde dehydrogenase can kill ovarian cancer stem cells by inducing necroptosis.

Review of «Intercellular Transfer of Microvesicles from Young Mesenchymal Stromal Cells Rejuvenates Aged Murine Hematopoietic Stem Cells» from STEM CELLS by Stuart P. Atkinson

Human embryonic stem cells derived from affected embryos during a pre-implantation diagnostic (PGD), as well as the conversion of somatic cells, such as skin fibroblasts, into induced pluripotent stem cells by genetic manipulation, offer the unique opportunity to have access to a large spectrum of disease - specific cell models.

Researchers applied the findings to a mouse model with a genetic mutation in a component of the ribosome — the machinery that makes proteins — and the rate of protein production was reduced in stem cells by 30 percent.

Their surprising discovery demonstrates that the vitamin A derivative ATRA (all - trans retinoic acid), a treatment for APL that is considered to be the first example of modern targeted cancer therapy, can block multiple cancer - driving pathways and, at the same time, eliminate cancer stem cells by degrading the Pin1 enzyme.

Reference article: The transcription factor GATA6 enables self - renewal of colon adenoma stem cells by repressing BMP gene expression Gavin Whissell, Elisa Montagni, Paola Martinelli, Xavier Hernando - Momblona, Marta Sevillano, Peter Jung, Carme Cortina, Alexandre Calon, Anna Abuli, Antoni Castells, Sergi Castellvi - Bel, Ana Silvina Nacht, Elena Sancho, Camille Stephan - Otto Attolini, Guillermo P. Vicent, Francisco X. Real and Eduard Batlle Nature Cell Biology (2014) Doi: 10.1038 / ncb2992

But no one has yet succeeded in making human embryonic stem cells by cloning.

For about a decade, researchers have been able to direct the fate of stem cells by tuning the stiffness of its microenvironment.

As an alternative to harvesting them from embryos, scientists can also obtain pluripotent stem cells by treating mature somatic cells with a cocktail of transcription factors to regress them so that they are nearly as flexible as embryonic stem cells.

This year, a team led by the Hebrew University of Jerusalem finally produced haploid human embryonic stem cells by forcing unfertilized egg cells to divide.

The team could establish the number of white blood cell - generating stem cells by studying the pattern of mutations found within the blood cells.

«It still remains to be determined whether the generation of stem cells by non-egg based approaches is going to be an effective approach.»

Last December, for instance, Chien's group reported finding markers for heart muscle stem cells by tracing their development from embryonic tissue.

In the animal model, the researchers eliminate some of the stem cells by deleting a particular gene in them.

This is a fascinating new field of thought in breast cancer research, especially given the team's findings that we might be able to stop cancer stem cells by blocking the molecule FAK.»

Researchers at Boston University School of Medicine (BUSM), under the direction of Sam Thiagalingam, PhD, found that a protein secreted by BLBC cells, called periostin (POSTN), acted to nurture and support cancer stem cells by activating a distinct signaling pathway in these cells.

They showed how ANG maintains stem cells by inducing a state of quiescence, or cellular dormancy, the first known evidence of ANG's suppressive activity.

• Scrutiny continued this week for Haruko Obokata, the Japanese stem - cell scientist whose apparent stunning advance — reprogramming adult stem cells by stressing them in acid — has proved difficult to reproduce, even by her own collaborators.