Sentences with phrase «stem cells capacity»

A new paradigm of medicine that relies on stem cells capacity to regenerate, regrow, and fully heal damaged tissues and organs in our bodies

Not exact matches

«When patients get desperate, they have a capacity to suspend disbelief,» said Sean Morrison, a stem cell biologist at the University of Texas Southwestern Medical Center in Dallas.

And with adult stem cells, they don't have the same capacity of self - renewal to double and redouble infinitely.

«With a better understanding of how potential is regulated, it could be possible to broaden the development spectrum of aging stem cells, allowing them to regain their capacity to produce cell types from earlier development stages, which in the long - term perspective could be relevant to future treatment methods for neurodegenerative disease.»

«TGF - beta functions as an important time signal that controls when a stem cell should stop producing one type of nerve cell and instead start producing another, while also gradually limiting the stem cell's future development capacity,» says Johan Ericson, Professor of Developmental Biology, who led the study.

Stem cells, which have to divide regularly to regenerate tissues with new cells, can produce telomerase, but not the amount required to counteract the shortening of telomeres that accumulates with aging: over time, the tissues have fewer fresh cells and they lose their regenerative capacity.

Paying for human eggs, many bioethicists argue, commodifies a human resource; Sandel, for example, a proponent of both research cloning and embryonic stem cell research, opposes the idea of financial inducement for what he calls «human reproductive capacity.»

Stem cells have the unique capacity not only to give rise to more stem cells, but also to generate differentiated progStem cells have the unique capacity not only to give rise to more stem cells, but also to generate differentiated progstem cells, but also to generate differentiated progeny.

As such, manipulating stem cells also holds much promise for biomedicine if their regenerative capacity can be harnessed.

The gradual shrinking of telomeres negatively affects the replicative capacity of human adult stem cells, the cells that restore damaged tissues and / or replenish aging organs in our bodies.

We lose many of those stem cells, along with their regenerative capacity, as we age.

This could be one of the mechanisms responsible for the reduced regeneration capacity in the aged brain as stem cells that retain larger amounts of damaged proteins require longer for the next cell division.

In comparison with the cells obtained with the technique developed by Yamanaka, the stem cells obtained by CNIO therefore represent an even earlier embryonic state, with greater capacity for differentiation.

Stem cells are renowned for their regenerative capacity, able to grow into many different kinds of cells in the body.

Their capacity to divide, differentiate and repopulate tissues, which typically declines with an organism's advancing age, resembled those of their stem - cell counterparts in younger animals.

These cells have an unlimited capacity to regenerate themselves, making more cancer stem cells and more tumors.

Therefore, those were chosen to test whether the molecules produced by the neural stem cells of patients alter the angiogenic capacity of the cells.

«The work is telling us that these [melanocyte] stem cells don't have an infinite capacity for self - renewal,» says geneticist Ian Jackson of the Medical Research Council Human Genetics Unit, U.K..

The results suggest that our lifespan might ultimately be limited by the capacity of our stem cells to keep replenishing tissues.

Holstege says this implies that most or all of the blood stem cells van Andel - Schipper started life with had already burned out and died, diminishing her body's capacity to keep regenerating vital tissues and cells.

They tested 120 neural stem cell lines in the lab for stability and robustness and in animals for the capacity to engraft with minimal immune rejection.

Their studies have shown that, while progenitor cells can give rise to benign lesions, only stem cells have the capacity to develop into deadly invasive tumours.

Phenotypic stability and unlimited self - renewal capacity of cell derived from pluripotent stem cells are essential properties for cell assay development for High Throughput Screening (HTS) strategies.

In the proposed project, Dr. Lampi Hermanson will produce NK cells from stem cells, inserting a chimeric antigen receptor (CAR) with the capacity to recognize mesothelin cells, which is expressed in 70 % of ovarian cancer patients.

Facilites A system of core facilities to strengthen national response capacity for disease outbreaks and stem cell research capacity.

The exploration of the therapeutic potential of stem cells requires the characterization of their biological properties, the deciphering of the mechanisms that underlie their pluripotency and their capacity at differentiation, by the understanding of the signals that direct their fate towards discrete cell phenotypes... Their therapeutic use requests further, in particular in the case of substitutive therapies, the analysis of their capacities of integration in injured adult tissues and of their potential tumorigenicity, as well as the development of original ways of delivery.

And in the February 6 issue of Cell Stem Cell, Dr. Ding and his colleagues, using the method he pioneered, demonstrated their capacity to do just that.

The overexpression of basic fibroblast growth factor boosts bone fracture healing capacity of mesenchymal stem cells via the secretion of paracrine - acting factors

ViaCyte's trial, with just one stem cell line, has the capacity to yield an unending amount of insulin - producing beta cells.)

Faculty Henri Jasper, PhD has already extended lifespan and healthspan in fruit flies by enhancing the regenerative capacity of the adult stem cells that line their mid-gut.

Ed Field currently is the Chief Operating Officer of Cytomedix, Inc. (OTCBB: CMXI), a US - based company that is developing and commercializing autologous regenerative biotherapies that promote healing by harnessing the innate regenerative capacity of platelets and adult stem cells.

Solid tumours are reported to possess a sub set of cells called Side Population expressing various stem like cell markers, self - renewal capacity and ability to give rise to differentiated cells [23, 24].

Rather, each tumor contains a small subset of cells with stem cell - like capacities that are responsible for initiating and sustaining tumor growth, while the bulk of the tumor cells lacks this ability.

I will discuss our latest results showing that satellite cells in their homeostatic quiescent state are equipped with quality control mechanisms to preserve their fitness, and how age - associate alterations in these protective mechanisms lead to stem cell loss of function and regenerative capacity.

The term «tumor stem cell» only reflects the fact that this is a tumor cell with capacities similar to normal stem cells, such as the capability to maintain itself indefinitely.

Pluripotent embryonic stem cells have the dual capacity to differentiate into all cell types and to self - renew.

First, the loss of mitotic competence of stem cells denies proliferative tissues of the capacity for renewal.

Pluripotent stem cells should not be confused with «adult» stem cells, which reside naturally in the body but have a finite capacity for reproduction and differentiation.

Embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) possess unlimited proliferative capacity and represent the infinite supply of pluripotent cells.

Grinenko T, Arndt K, Portz M, Mende N, Günther M, Cosgun KN, Alexopoulou D, Lakshmanaperumal N, Henry I, Dahl A, Waskow C Clonal expansion capacity defines two consecutive developmental stages of long - term hematopoietic stem cells.

She is interested in understanding how stem cells in regeneration systems undertake a full regeneration response, and how this capacity has been restricted in mammalian equivalents.

According to established research, patients who received stem cells directly to the heart have experienced improved blood flow to their heart and improvements in functional capacity.

But the eyebrow - raising reports claimed that adult stem cells sometimes behave like their embryonic counterparts, mimicking their trademark capacity to engender all types of cells — an ability dubbed pluripotency.

His ultimate aim is to harness the regenerative capacity of these adult stem cells for therapeutic use.

Title: Skeletal muscle stem cells adopt a dormant state post mortem and retain regenerative capacity Authors: Latil M, Rocheteau P, Châtre L, Sanulli S, Mémet S, Ricchetti M, Tajbakhsh S, Chrétien F Date: 2012 Publication Details: Nature Communications 2012, 3 (903)

Because they have the capacity to detect issues in the body which are causing pain or dysfunction, stem cells are able to respond and provide the correct «tools» needed for healing.

The self - renewable capacity of these cells, their ability to differentiate into several tissue progenitors (neural, mesenchymal stem cells...), and the possibility to work with mutated cell lines define human stem cells as a good basis for screening compounds libraries in order to discover new potential drugs for monogenic diseases.

As a function of age, the capacity for adult stem cells to self - renew declines.

The stem cells display self - renewal capacity and differentiate into neural crest derivatives including epidermal pigment - producing melanocytes.

Stem cell research holds tremendous promise for medical treatments, but scientists still have much to discover about how stem cells work and their capacity for healStem cell research holds tremendous promise for medical treatments, but scientists still have much to discover about how stem cells work and their capacity for healstem cells work and their capacity for healing.