Sentences with phrase «stem cells express»

ES cell chromatin is open at a global level [3], and the stem cells express high levels of chromatin remodeling factors.

Hematopoietic stem cells express the markers CD34 and CD133 and can repopulate a myeloablated recipient after allogeneic or autologous transplantation.

Mesenchymal stem cells express a surface protein called α4β1 integrin as they turn into osteoblasts.

The fact that these stem cells express fewer metabolic genes might be one way to protect the cells from the daily grind faced by their peers, and to limit the production of metabolic byproducts that can damage DNA.

At one end of the hierarchy are stem cells expressing most pluripotency genes studied and few lineage specific genes; at the other end are fully committed cells that have extinguished the pluripotency program, and in between there is a continuous spectrum.

Treatment of Type 1 Diabetes With Adipose Tissue — Derived Stem Cells Expressing Pancreatic Duodenal Homeobox 1 (December 2009) in Stem Cells and Development.

Our collaborative effort revealed that the breast cancer stem cells expressed far fewer microRNAs than their more differentiated counterparts.

Not exact matches

You said, «Secondly, how do you know that god isn't making all these fetus's with the express intetion of giving their stem cells for the good of humanity?»

One clear positive element in the stem - cell debate for me was hearing the top researchers in biomedical science reinforce The Catechism of the Catholic Church (CCC 343: «Man is the summit of the Creator's work, as the inspired account expresses by clearly distinguishing the creation of man from that of other creatures»).

Green: the stem cells and their progeny express protein.

Previous research shows human induced pluripotent stem cells (hiPSCs)-- generated directly from adult cells — can express markers for a wide variety of cells, including those that secrete NP.

In a series of experiments, the researchers first identified a set of 19 transcription factors that were expressed at significantly greater levels in cultured human glioblastoma stem cells capable of tumor propagation than in differentiated tumor cells.

«But if you have stem cells that are over expressing this protein TRAF6, they may proliferate longer and they may repair the muscle much more effectively.»

«The antibody binds to a specific protein, called CD44s, which is expressed on the surface of pancreatic cancer stem cells.

The team also found that ERAS, a tumorigenic gene expressed in mouse embryonic stem cells and iPSCs, was mutated and dysfunctional in the mole - rat iPSCs.

«The views that are expressed there are very much different from researchers in stem cell work and reproductive medicine.»

The team reports that the adenomas grow from cells that express a gene called Lgr5 +, which is also active in normal intestinal stem cells.

Already, we see that cells from people with bipolar disorder are different in how often they express certain genes, how they differentiate into neurons, how they communicate, and how they respond to lithium,» says Sue O'Shea, Ph.D., the experienced U-M stem cell specialist who co-led the work.

Using a nuclear protein expressed in follicle stem cells (FSCs), the researchers found that castor, which plays an important role in specifying which types of brain cells are produced during embryonic development, also helps maintain FSCs throughout the life of the animal.

Kotton built a reporter gene that glowed green when the stem cells first expressed Nkx2 - 1, and Hawkins engineered the same gene into human cells.

Stem cell advocates have been expressing serious worry that ethical requirements spelled out in the draft guidelines — in particular, informed consent procedures for embryo donors — will rule out the use of many existing human embryonic stem cell lines, including the 21 lines approved under the Bush AdministratStem cell advocates have been expressing serious worry that ethical requirements spelled out in the draft guidelines — in particular, informed consent procedures for embryo donors — will rule out the use of many existing human embryonic stem cell lines, including the 21 lines approved under the Bush Administratstem cell lines, including the 21 lines approved under the Bush Administration.

We should not only question the construct of the «ethics of curing,» as I will show, but we also need to look critically at reservations toward research on embryonic stem cells as they are expressed in our society.

The researchers found that, in test animals, modification of the blood - forming stem cells resulted in more than two years of stable production of CAR - expressing cells without any adverse effects.

In normal mice, stem cells (pink) express dystrophin (green) and are able to easily generate new muscle fibers, but in the disease model, there is no dystrophin and the stem cells lose their sense of direction and have trouble generating new muscle fibers.

And IL - 22 helped tumor cells express stem - cell genes through epigenetic changes to these genes.

In one study, geneticist Joseph Ecker at the Salk Institute in California took various stem cell lines reprogrammed from skin, fat, and other tissues and examined each line's genome for dna methylation, chemical marks that alter how genes are expressed.

In the current study, Dr. Rudnicki and his team discovered that muscle stem cells also express the dystrophin protein, and without this protein, they produce ten-fold fewer muscle precursor cells, which in - turn generate fewer functional muscle fibres.

Sox2 control region - deleted cells have lost the typical appearance of embryonic stem cells (C) and do not express Sox2 (D).

A large body of research has reported that Nanog is allelically regulated — that is, only one copy of the gene is expressed at any given time — and fluctuations in its expression are responsible for the differences seen in individual embryonic stem (ES) cells» predilection to differentiate into more specialized cells.

These are images of mouse embryonic stem cells which grow in a round colony of cells (A) and express Sox2 (B), shown in red.

Whitehead Institute researchers have determined that the transcription factor Nanog, which plays a critical role in the self - renewal of embryonic stem cells, is expressed in a manner similar to other pluripotency markers.

The researchers» investigations revealed that Del - 1 was expressed by at least three cell types in the bone marrow that support hematopoetic stem cells: endothelial cells, CAR cells and osteoblasts.

A new technique for sequencing the RNA in a single cell has been revolutionary, Ngai said, allowing researchers to trace which stem cells in a densely packed tissue become specialized, based on the mRNA present in the cell, which indicates which genes are being expressed.

They also expressed lower levels of an RNA message that controls the expression of a family of proteins called SOC, known to inhibit the migration of hematopoietic stem cells.

Further investigations revealed that the nanoparticles caused some genes related to the proliferation and differentiation of stem cells to express differently.

The scientists already knew how to encourage mouse embryonic stem cells to express nestin, and they wondered if they could coax their nestin - positive cells to take on more characteristics of pancreas cells.

The team immersed the stem cells in four different types of these cultures and analysed which genes they expressed in which environment, and to what extent.

Mouse embryonic stem cells injected into rat brains express the AHD2 protein marker (yellow) characteristic of cells lost in Parkinson's disease.

Significantly, cells with reduced mtDNA became self - renewing and expressed specific cell surface markers characteristic of breast cancer stem cells.

Unlike OCT4, these genes can only be studied in human embryos because they are not expressed the same way, or at all, in mouse embryos or immortalized lines of human stem cells, says her colleague Robin Lovell - Badge, also at the Crick Institute.

These differently expressed microRNAs may contribute to stem cell and epithelial (tissue cells) abnormalities in diabetic corneas.

Injecting the TRAIL - expressing stem cells into the carotid artery, a likely strategy for clinical application, led to significantly slower tumor growth and increased survival, compared with animals receiving unaltered stem cells or control injections.

To devise a potential new therapy, the investigators engineered a population of neural stem cells to express a potent version of a gene called TRAIL, which codes for a molecule that activates cell - death - inducing receptors found only on the surface of cancer cells.

To facilitate removal of the therapeutic stem cells from the brain at the conclusion of therapy, the researchers created cells that, in addition to TRAIL, express a viral gene called HSV - TK, which renders them susceptible to the effects of the antiviral drug ganciclovir.

The generation of iPSCs is relatively simple in concept: ectopically express a cocktail of stem cell reprogramming factors and wait for cells to de-differentiate.

The results of our microRNA (miRNA) profile analysis for these cells revealed that CSCs that are highly metastatic to bone and brain expressed significantly lower level of miR - 7 and that this miRNA was capable of modulating one of the essential genes for induced pluripotent stem cell, KLF4.

Several tests in cultured cells indicated that ganciclovir would cause the death of HSV - TK - expressing stem cells, and testing in the mouse model confirmed that administration of the drug after successful treatment of brain metastases successfully eliminated therapeutic stem cells that also expressed HSV - TK.

In the proposed project, Dr. Lampi Hermanson will produce NK cells from stem cells, inserting a chimeric antigen receptor (CAR) with the capacity to recognize mesothelin cells, which is expressed in 70 % of ovarian cancer patients.

But of course, posed this way the question does not distinguish between stem cells obtained in different ways (and indeed it is sensible to assume that those who expressed opposition in response to this question believed they were being asked about embryonic stem cells, although the survey does not allow us to know that with confidence).

And yet again, when presented with the case for embryonic stem cell research primarily on the grounds of curing disease, the respondents expressed support.