Instead of using white blood cells, the British researchers, working with a Dutch group, want to
take stem cells from bone marrow and insert the ADA gene into these.
To study blood development, researchers typically purify blood
stem cells from the bone marrow of mice and transplant them into mice exposed to radiation, thus creating a tractable experimental system.
«When we transplanted our labeled
blood stem cells from the bone marrow into other mice, only a few stem cells were active in the recipients, and many stem cells were lost,» Rodewald explains.
(The cells would be obtained by giving the workers a drug that nudges blood
stem cells from the bone marrow into the bloodstream, then hooking them to a machine that filters out the stem cells.)
The doctors» plan was to kill off Brown's cancer - producing bone marrow cells with intensive chemotherapy and replace them
with stem cells from the bone marrow of a healthy donor.
They left a control group completely untreated and treated the second group using
mouse stem cells from bone marrow, which they injected into the skin near the wound.
Now, a new study evaluates the pros and cons of
harvesting stem cells from bone marrow rather than blood and suggests there are benefits to both approaches, but no survival differences between the two methods.
She and her colleagues then
collected stem cells from the bone marrow of drowsy and of well - rested mice and injected them into 12 mice that had received what would normally be a lethal dose of radiation.
A few studies showed that
stem cells from bone marrow could create scar tissue.
But, it was known that when HIF - 1 normally activates signals in the body to build new vessels, one of the many types of cells recruited to the site of new vessel growth is a population of
stem cells from the bone marrow, which are called bone marrow - derived angiogenic cells.
Stem cells from the bone marrow can develop into cardiac muscle, as well as liver, brain, nerve, fat and skin tissue.
Blood and bone marrow stem cell transplantation involves the harvesting of
stem cells from the bone marrow or the blood of a patient or donor.
But bone marrow stem cells have their limitations because, unlike stem cells from cord blood which are pluripotent (that is the cells can become any other cell in the body - from the Latin for very many and having power),
stem cells from bone marrow are only multipotent (Latin: many and having power).