When blasted with 10 Gy of irradiation — enough to wipe out all blood
stem cells in the bone marrow of normal mice — mutant mice that were unable to fully activate p53 experienced only a modest blood count drop.
Research conducted at Japan's National Institute for Materials Science built on previous findings that gold nanoparticles can
encourage stem cells in the bone marrow to differentiate into bone cells, and that specific biomolecules can inhibit or promote stem cell differentiation.
Researchers at the Whitehead Institute in Cambridge, Massachusetts, US, have now found that
adult stem cells in bone marrow gradually lose their ability to regenerate without their normal complement of membrane - bound prions.
However, these poisons can also do significant harm to other dividing cells such as those found in the stomach lining and in hair and nail follicles, as well as the blood and
immune stem cells in the bone marrow.
Stem cells in bone marrow need to produce hydrogen sulfide in order to properly multiply and form bone tissue, according to a new study from the Center for Craniofacial Molecular Biology at the Ostrow School of Dentistry.
The innate system —
via stem cells in the bone marrow — mobilizes macrophages, which are a type of white blood cell that swallows and kills invading bacteria like Mycobacterium tuberculosis (Mtb) that causes TB.
Although Osteolectin is known to be made by certain bone marrow and bone cells, CRI researchers are the first to show Osteolectin promotes the formation of new bone from
skeletal stem cells in the bone marrow.
Research Supports Promise of Cell Therapy for Bowel Disease WINSTON - SALEM, N.C. - Feb. 28, 2013 - Researchers at Wake Forest Baptist Medical Center and colleagues have identified a special population of
adult stem cells in bone marrow that have the natural ability to migrate to the intes
They have also identified two distinct stem - cell like populations from which relapse can arise in different patients in this aggressive cancer that they previously showed starts in
blood stem cells in the bone marrow.
He proved it in 2003 by first X-raying mice to kill off all
the stem cells in their bone marrow, then repopulating the bone with stem cells tagged with a fluorescent marker.
«
The stem cells in your bone marrow are sitting there like they are in a safety - deposit box at your bank,» he says.
In the paper that is now published, they make
the stem cells in the bone marrow to produce more telomerase, thus enabling them to repair their excessively shortened telomeres.
Stem cells in the bone marrow can differentiate either into bone cells or fat cells, and the glitazones drive them to fat at the expense of bone.
This rejuvenated
the stem cells in the bone marrow of the older mice that replenish their blood, and led to a wave of studies comparing the blood of old and young mice to try and identify the youth - giving substance.
Stem cells in the bone marrow are normally responsible for producing blood.
In the study, USC Stem Cell researcher Casey Brewer and colleagues in the laboratory of Rong Lu found that transplantation dose affects the behavior of blood - forming
stem cells in bone marrow — called hematopoietic stem cells, or HSCs.
Leukemia starts in the «hematopoietic»
stem cells in the bone marrow that give rise to all the different kinds of mature blood cells.
Researchers in Bern have discovered that, during a viral infection, immune cells control the blood
stem cells in the bone marrow and therefore also the body's own defenses.
Now, for the first time, researchers at the Department of Medical Oncology at the University of Bern and Bern University Hospital headed by Prof. Adrian Ochsenbein have investigated how the blood
stem cells in the bone marrow are regulated by the immune system's so - called T killer cells during a viral infection.
Furthermore,
stem cells in bone marrow may form not just hematopoietic cells, but cardiac muscle cells, neural cells, and other types of cells; this is an example of stem - cell plasticity.
The pool of
stem cells in the bone marrow is continuously undergoing a process of self - renewal and differentiation.
The radiation had caused widespread DNA damage, followed by cellular breakdown, hitting hardest at the dividing cells, such as
the stem cells in the bone marrow, gut and skin.
Her studies of
the stem cells in bone marrow and their requirements for successful growth have contributed to advances in transplantation techniques that have saved the lives of patients with leukemia and other blood cancers.
One of her first professional achievements was to overturn a decade of research by some of the most respected scientists in the field, who erroneously thought that
stem cells in the bone marrow had the power to become any cell in the body.
A crude example of this would be someone with leukemia getting chemotherapy to wipe out the blood
stem cells in their bone marrow and then having those stem cells replaced via a bone marrow transplant.
In addition to defects in blood stem cells, MDS is also affected by the cells that surround
the stem cells in the bone marrow, the so - called stroma cells.
The stem cells in bone marrow were particularly tantalizing.
Blood - forming
stem cells in the bone marrow are the affected cells in MDS.
Previous research has shown that the protein histone deacetylase 3, or HDAC3, turns off the genes that encourage
the stem cells in our bone marrow to make and store fat instead of making bone.