A crucial aspect of the mouse model development was the ability to use what's called the «Sleeping Beauty» technique of inserting genes
into stem cells in the brain of newborn mice.
Developing new imaging tools that can track
cancer stem cells in the brain of treated patients is also an important objective and some of the Emory investigators are evaluating the use of nanoparticles to this purpose.
Our investigations also open a new route for understanding how different physiological states of the body influence
stem cells in the brain during health and disease, and opens new ways for thinking about therapy,» says Fiona Doetsch.
After introducing
stem cells in brain tissue in the laboratory and seeing promising results, Prof. Offen leveraged the study to mice with Alzheimer's disease - like symptoms.
 The possibility of developing therapeutics that can specifically target the brain cancer stem cells is an exciting new development but will have to proceed with caution to spare
normal stem cells in the brain.
«Single - cell analysis supports a role for cancer
stem cells in brain tumor growth: Strong evidence that cancer stem cells are important drivers of tumors in patients.»
«In the past it was deemed technically impossible to follow single
cell stem cells in the brain over time given the deep localization of the hippocampus in the brain,» said Jessberger.
Researchers at Karolinska Institutet in Sweden have succeeded in explaining
how stem cells in the brain change to allow one type of stem cell to produce different cell types at different stages.
A September 2002 follow - up study found no evidence for widespread transdifferentiation of blood -
forming stem cells in brain, liver, kidney, gut and other tissues.
Recent research by neuroscientist Fred Gage and colleagues at the University of California (UC), San Diego, has shown that one of the most common types of jumping gene in people, called L1, is particularly abundant in
human stem cells in the brain that ultimately differentiate into neurons and plays an important role in regulating neuronal development and proliferation.
«Electrical mobilization and guidance of
stem cells in the brain therefore provides a potential approach to facilitate stem cell therapies for brain diseases, stroke and injuries,» Zhao said.
Cambridge, UK (Scicasts)-- Scientists have identified a new type of
stem cell in the brain which they say has a high potential for repair following brain injury or disease.
With dementia, it turns out that the opposite is true: the Burnham team discovered that HIV / AIDS could co-opt the checkpoint pathway to
prevent stem cells in the brain from dividing and multiplying.
Although BBB glial cells are proposed to receive as - yet - unidentified signal (s) from the fat body and re-activate neural
stem cells in the brain by secreting Dilp6 [49][50], CCHa2 - R > nlsGFP was undetectable in the BBB glial cells (S1G — S1I Fig).
By delicately
labeling stem cells in the brains of live mice and recording the fates of their offspring, Obernier discovered that the cells don't divide in a self - renewing fashion, as the field had predicted.
Thereby, training and activity very directly act
upon stem cells in the brain and induce them to produce neurons that serve a function in learning and memory.
«Learning these properties
about stem cells in the brain is essential for any future attempt to entice these cells to make new neurons for brain repair.»
Castro and Lowenstein's team used what's called the «Sleeping Beauty» technique to insert mutated genes known to be involved in cancer
into stem cells in the brains of newborn mice.
At the ISSCR public symposium in Stockholm, stem cell scientists from Germany, Sweden and the U.S. will explore during a moderated panel discussion the role of
stem cells in the brain during our lives from development and through adulthood.
The key to more effective treatment for glioma is to get to grips with the glioma stem cells, which share many characteristics with the normal
neural stem cells in the brain.
But you can imagine taking stem cells, modifying them with an immune - stimulating protein like interleukin - 12, putting
the stem cells in the brain, where they seek out tumors like a heat - seeking missile.