Sentences with phrase «stem cells in the laboratory»

Although British researchers had discovered embryonic stem cells in laboratory animals in 1981, it wasn't until 1998 that a Wisconsin team announced it had isolated stem cells from human embryos for the first time.

To produce the cells, the Salk scientists developed a combination of chemical signals that directed human stem cells in a laboratory dish to become spatially oriented.

Researchers have successfully created functional sperm cells from mouse stem cells in the laboratory, then implanted those cells into rodents» egg cells to produce healthy, fertile offspring.

Prior to QB3, she studied mechanisms of self - renewal and survival in human embryonic stem cells in the laboratory of Professor Douglas Melton, completing her PhD at Harvard University in 2012.

Not exact matches

Previously, Dr. Nikolic was an Assistant Professor in Medicine at Harvard Medical School where he led an advanced immunology laboratory for tolerance induction and stem - cell transplantation at Massachusetts General Hospital / Harvard Medical School.

We wanted to understand what types of differences are always there, what is causing them, and what they mean,» says Juan Carlos Izpisua Belmonte, a professor in Salk's Gene Expression Laboratory and co-senior author, with Kelly Frazer of the University of California, San Diego, on the new paper, which was published in Cell Stem Cell in April 2017.

Beginning in the 1970s, physicians learned how to harvest skin stem cells from a patient with extensive burn wounds, grow them in the laboratory, then apply the lab - grown tissue to close and protect a patient's wounds.

After deciphering this natural differentiation process, the investigators duplicated it in the laboratory dish by adding a sequence of proteins, called growth factors, to the fluid bathing the stem cells.

Three of these themes represent the key scientific steps in moving stem cells from the laboratory into the clinic — the bioengineering and biology of stem cells, and the clinical applications of that research.

Adding stem cells from human bone marrow to a broken diabetic bone enhances the repair process, increasing the strength of the newly formed bone, according to a laboratory - based study presented at the European Congress of Endocrinology in Dublin.

The researchers added human bone marrow stem cells from a non-diabetic donor to a bone fracture in laboratory pre-clinical studies.

According to Izpisúa Belmonte, who is also a professor at the gene expression laboratories of the Salk Institute for Biological Studies in San Diego, California, CMRB aims to become «a research centre of excellence in south Europe in the line of world - recognized institutions such as the Salk or the Whitehead institutes, where both pre - and postdoctoral researchers receive multidisciplinary training of the highest quality» in stem cell biology and cell regeneration.

Dr. Zubair, medical and scientific director of the Cell Therapy Laboratory at Mayo Clinic in Florida, says the experiment will be the first one Mayo Clinic has conducted in space and the first to use these human stem cells, which are found in bone marrow.

«It's taken years of trial and error, making educated guesses and taking baby steps to finally produce functioning human muscle from pluripotent stem cells,» said Lingjun Rao, a postdoctoral researcher in Bursac's laboratory and first author of the study.

Of particular interest to stem cell and regenerative medicine researchers, the finding may lead to laboratory methods to create heart cells that function more like those found in adult hearts.

«I've been in research for 30 years, and nothing has created more excitement than stem cell research,» notes Richard Boyd, an immunologist and director of the Monash immunology and stem cell laboratories in Australia.

These transgenic stem cells also readily created intestinal tissues called «organoids» in laboratory dishes.

They also plan to evolve the chemistry behind the materials so that it may be possible for gels to better mimic more complex cellular environments beyond the control of stiffness alone, as well as investigate how dynamic changes in matrix properties — a hallmark of the stem cell niche — can be mimicked in the laboratory.

The laboratory process, described in the journal Scientific Reports, entails genetically modifying a line of human embryonic stem cells to become fluorescent upon their differentiation to retinal ganglion cells, and then using that cell line for development of new differentiation methods and characterization of the resulting cells.

So Ke Cheng, Hu Zhang, Jinying Zhang and colleagues wanted to see whether placing stem cells in inexpensive hydrogels with designed tiny pores that are made in the laboratory would work.

«These findings suggest that BLBC cells have an innate ability to establish a local microenvironment that is supportive of cancer stem cells,» explained Thiagalingam, associate professor in Genetics & Genomics, Medicine, and Pathology & Laboratory Medicine, at BUSM.

Research in the laboratory of Rebecca Wingert, the Gallagher Family Associate Professor of Adult Stem Cell Research in the Department of Biological Sciences at the University of Notre Dame, has confirmed the key role of a certain small molecule in the development of kidney structures in zebrafish, a widely used model for human kidneys.

In a collaborative effort between the Gladstone laboratories of Benoit Bruneau, PhD, Katherine Pollard, PhD, and Dr. Srivastava, the scientists used stem cell technology to make large amounts of endothelial cells from patients with CAVD, comparing them to healthy cells and mapping their genetic and epigenetic changes as they developed into valve cells.

«We found that fibrinogen stops adult stem cells from transforming into the mature cells that produce myelin,» explained first author of the study Mark Petersen, MD, a visiting scientist in Akassoglou's laboratory and an assistant adjunct professor of pediatrics at UCSF.

A team from Cold Spring Harbor Laboratory in Long Island, N.Y., reports that it staved off full - blown metastasis in mice by preventing mini-tumors in the lungs from recruiting stem cells called endothelial progenitors, which assemble into blood vessels to nourish the malignancy.

In a new study published in Science, the laboratory of Sebastian Jessberger, professor in the Brain Research Institute of the University of Zurich, has shown for the first time the process by which neural stem cells divide and newborn neurons integrate in the adult mouse hippocampuIn a new study published in Science, the laboratory of Sebastian Jessberger, professor in the Brain Research Institute of the University of Zurich, has shown for the first time the process by which neural stem cells divide and newborn neurons integrate in the adult mouse hippocampuin Science, the laboratory of Sebastian Jessberger, professor in the Brain Research Institute of the University of Zurich, has shown for the first time the process by which neural stem cells divide and newborn neurons integrate in the adult mouse hippocampuin the Brain Research Institute of the University of Zurich, has shown for the first time the process by which neural stem cells divide and newborn neurons integrate in the adult mouse hippocampuin the adult mouse hippocampus.

Researchers remove these mechanically and, with some luck, can nurture them into an embryonic stem cell line that lives in perpetuity in the laboratory.

Indeed, when fat stem cells isolated from healthy obese individuals were exposed to interleukin - 6 in the laboratory, they behaved like those obtained from individuals with risk of diabetes.»

Dieter Egli and Scott Noggle of the New York Stem Cell Foundation Laboratory in New York City and colleagues fused skin cells with unfertilised human eggs.

Stem cells hold great promise for transforming medical care related to a diverse range of conditions, but the cells often lose some of their therapeutic potential when scientists try to grow and expand them in the laboratory.

Reporting their laboratory findings in the journal Aging, the team observed that addition of DPI to a mixed population of cells eliminated the tumour initiating cancer stem cells.

«This lets us keep age - related signatures in the cells so that we can more easily study the effects of aging on the brain,» says Rusty Gage, a professor in the Salk Institute's Laboratory of Genetics and senior author of the paper, published October 8, 2015 in Cell Stem Cell.

In the monkey, when we tried injecting 20 or 30 laboratory - cultured pluripotent stem cells, nothing happened.

In particular, opponents of embryonic stem cell research have repeatedly pointed to the supposed power of stem cells extracted from the adult body, which in the hands of at least one laboratory seemed to nearly match that of embryonic stem cellIn particular, opponents of embryonic stem cell research have repeatedly pointed to the supposed power of stem cells extracted from the adult body, which in the hands of at least one laboratory seemed to nearly match that of embryonic stem cellin the hands of at least one laboratory seemed to nearly match that of embryonic stem cells.

«The results were remarkable, with significant shrinkage in patient - derived tumors,» said Memarzadeh, who also is an associate professor of obstetrics and gynecology and the director of the G.O. Discovery Laboratory at the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and associate professor.

The world's first chimeric monkeys were created in a laboratory last year, and they offer surprising new insights into embryonic stem cell therapy: One reason for often - poor treatment outcomes may be that we're using embryos that are, strangely, just too old.

Previous studies have demonstrated that particular cell types, such as those that constitute the retina or cornea, can be created in the laboratory from pluripotent stem cells.

Mature embryonic stem cells cultivated in the laboratory can, under the right conditions, be backed up in their development to the more immature stem cell type.

The iPSCs were then reprogrammed to become neurons in collaboration with the laboratory of Larry Goldstein, PhD, director of the UC San Diego Sanford Stem Cell Clinical Center.

Further testing in the laboratory dish showed that hematopoietic stem cells from the sleep - deprived mice responded less strongly than their peers to naturally occurring chemical signals that trigger cellular migration.

The antibiotic, Doxycycline, followed by doses of ascorbic acid (Vitamin C), were surprisingly effective in killing the cancer stem cells under laboratory conditions, according to the research published in the journal Oncotarget.

Salk scientists and colleagues have proposed new molecular criteria for judging just how close any line of laboratory - generated stem cells comes to mimicking embryonic cells seen in the very earliest stages of human development, known as naïve stem cells.

«For example, there is a huge amount of interest and excitement globally in growing cerebral organoids» — miniature brain - like organs that can be studied in laboratory experiments — «from stem cells to model human brain development and disease mechanisms.

On laboratory dishes, these stem cells were found to be havens for viral reproduction, resulting in cell death and / or disruption of cell growth.

Although the research was done in laboratory mice, the findings have possible implications for human stem cell transplants.

In the study, USC Stem Cell researcher Casey Brewer and colleagues in the laboratory of Rong Lu found that transplantation dose affects the behavior of blood - forming stem cells in bone marrow — called hematopoietic stem cells, or HSCIn the study, USC Stem Cell researcher Casey Brewer and colleagues in the laboratory of Rong Lu found that transplantation dose affects the behavior of blood - forming stem cells in bone marrow — called hematopoietic stem cells, or HStem Cell researcher Casey Brewer and colleagues in the laboratory of Rong Lu found that transplantation dose affects the behavior of blood - forming stem cells in bone marrow — called hematopoietic stem cells, or HSCin the laboratory of Rong Lu found that transplantation dose affects the behavior of blood - forming stem cells in bone marrow — called hematopoietic stem cells, or Hstem cells in bone marrow — called hematopoietic stem cells, or HSCin bone marrow — called hematopoietic stem cells, or Hstem cells, or HSCs.

One of the greatest achievements in recent biomedical research was in 2006 when Shinya Yamanaka managed to create embryonic stem cells (pluripotent stem cells, induced in vitro, or in vitro iPSCs) in a laboratory from adult cells, via a cocktail of just four genes.

Stem cells obtained in mice also show totipotent characteristics never generated in a laboratory, equivalent to those present in human embryos at the 72 - hour stage of development, when they are composed of just 16 cells.

She thinks that data from embryos cultured for nearly two weeks in the laboratory will provide more useful information than Egli's stem cell studies.

After introducing stem cells in brain tissue in the laboratory and seeing promising results, Prof. Offen leveraged the study to mice with Alzheimer's disease - like symptoms.