So far researchers have not been able to isolate or identify
stem cells in these organisms.
Not exact matches
Such
cells are found
in organisms that can divide and differentiate into specialized
cell types and can self - renew to produce more
stem cells.
No embryo has been generated, no
organism «cloned» if ANT - OAR succeeds
in its goal of producing nothing other than pluripotent
stem cells.
This method would also enable them to follow potential aging processes that occur
in blood
stem cells in detail as they occur naturally
in a living
organism.
«We have now developed the first model where we can observe the development of a
stem cell into a mature blood
cell in a living
organism.»
Organisms like zebra fish readily dedifferentiate
cells near the injury, undergoing a cellular age regression
in which «they form something like
stem cells, although they are not quite the same as
stem cells,» says Keating.
It performs this critical service
in embryonic development, growing
organisms and
in a few specialized adult
cell lines, including
stem cells.
Laux's team studied the
stem cells in the model
organism of the Arabidopsis plant, or rock cress, which is part of the Brassicaceae family of plants, including mustard and cabbage.
Apart from advancing our understanding of how plants regulate their growth and shape, this research presents new questions for
stem cell researchers
in regards to
cell size checkpoints and their importance during
organism development.
«
In other words, the activity of
stem cells needs to be precisely regulated to meet the needs of an
organism.
Scientists from the Spanish National Cancer Research Centre (CNIO) have discovered that NANOG, an essential gene for embryonic
stem cells, also regulates
cell division
in stratified epithelia — those that form part of the epidermis of the skin or cover the esophagus or the vagina —
in adult
organisms.
Schaal, dean of the faculty of arts and sciences at Washington University
in St. Louis, called for more effective communication and public engagement by scientists
in explaining their work, both to policy makers and to the general public, across a range of topics — climate change, evolution,
stem cells, and use of genetically modified
organisms (GMOs)
in agriculture.
«To really understand how one
cell becomes totipotent [a
stem cell] and then becomes something else, you need to know how it integrates
in an
organism,» Miglietta said.
The sequencing and statistical techniques the team developed can also be used by others studying regulation of
stem cells in other tissues, organ systems or
organisms, he said.
In contrast, embryonic
stem cells are pluripotent which means they can make all the
cells of the
organism, but typically not the extra-embryonic tissue.
Their capacity to divide, differentiate and repopulate tissues, which typically declines with an
organism's advancing age, resembled those of their
stem -
cell counterparts
in younger animals.
Just a few kinds of signals control the fates of
cells that either maintain their
stem cell state, divide or differentiate
in a developing
organism.
A full realisation of the medical potential of
stem cells for human health will likely depend on a reinforcement of, and development of a whole continuum of studies ranging from those
in vivo using model
organisms, to
cell - based therapies
in the clinic.
The model
organism offers a way to better understand
stem cell - driven regeneration processes, an important step
in regenerative medicine and the promise of therapies to repair or replace damaged human tissue.
«It's really interesting to be embedded within the context of the Thomson lab and
in the whole
stem cell milieu, and understanding how this axolotl might be employing the same pathways that are present
in other
organisms — and possibly people,» Nelson says.
We will use the fruitfly Drosophila melanogaster as an experimental model, as this tractable
organism experiences age - related changes of their
stem cells that are similar to the ones observed
in mammals.
In adult
organisms,
stem cells and progenitor
cells act as a repair system for the body, replenishing specialized
cells, but also maintain the normal turnover of regenerative organs, such as blood, skin, or intestinal tissues.
We will mine and exploit information from studies and screens
in model
organisms, but our primary focus is on the paradigmatic mammalian
stem cell systems - haematopoiesis and epithelia
in vivo, and embryonic and neural
stem cells in vitro.
In animal systems, pluripotency can be verified through direct means: pluripotent stem cells can be introduced into an developing embryo and thus the cellular developmental potential of any given in vitro preparation can be directly determined by observing the amount of chimaerism or viability of organisms partially or fully derived from in vitro stem cell
In animal systems, pluripotency can be verified through direct means: pluripotent
stem cells can be introduced into an developing embryo and thus the cellular developmental potential of any given
in vitro preparation can be directly determined by observing the amount of chimaerism or viability of organisms partially or fully derived from in vitro stem cell
in vitro preparation can be directly determined by observing the amount of chimaerism or viability of
organisms partially or fully derived from
in vitro stem cell
in vitro
stem cells.
By studying the planarian we hope to understand how
stem cells are regulated to produce missing tissues and organs
in the context of a whole
organism.
But because
stem cells can become any kind of tissue, human - animal research
in the field of «regenerative medicine» raises greater ethical issues and adds, for some, a visceral unease about the
organism that could be produced.
Since regeneration recapitulates
in broad strokes embryonic development, during which a complex multi-cellular
organism develops from a handful of embryonic
stem cells, the researchers began by comparing gene expression patterns between the two processes.
Currently,
stem cell research focuses on renewal and differentiation of
stem cells and the molecular mechanisms of its pluripotency - or their ability to develop into any type of
cell - using human embryonic
stem cells, induced pluripotent
stem cells, and
stem cells in simpler
organisms.
Trying to find the most basic answer to how
stem cells «know» to differentiate to different
cells in an
organism is probably as difficult as how molecules combine to form a living
organism.