Sentences with phrase «stem cells increased»
The study found that when brain cells were exposed to ar - tumerone, neural stem cells increased in number through enhanced proliferation.
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What do you think of President Obama's decision to increase federal dollars for embryonic stem cell research?
Interestingly, none of the opponents of embryonic stem cell research have called for research programs that might increase the odds of embryo survival.
The increasing use of in - vitro - fertilisation techniques, and the emergence of new possibilities involving human cloning, mixing of human and animal genetic elements, and the use of embryonic stem cells for research, among other things, brought the need for further teaching.
But harvesting requires invasive surgery, and bestowing stem cell properties on adult cells takes a two - step process that can increase the risk of the final cells becoming cancerous.
«The genetic correction doesn't increase the number of genetic anomalies that you can find in iPS cells,» says Ludovic Vallier, a stem - cell biologist at the University of Cambridge, UK, and one of the study's co-authors.
The latest findings show that genetic defects in the body's ability to manufacture carnitine might be associated with an increased risk of autism because carnitine deficiency interferes with the normal processes by which neural stem cells promote and organize embryonic and fetal brain development.
Immunohistochemical imaging of female human amniotic stem cells incubated with nanoparticles demonstrated a significant increase in uptake compared to male cells.
«We expect to see a significant increase in spend in the stem cells arena, mostly in the academic sector,» Burrill says.
CEP63 depletion increases stem cell death in the developing mouse brain.
Adding stem cells from human bone marrow to a broken diabetic bone enhances the repair process, increasing the strength of the newly formed bone, according to a laboratory - based study presented at the European Congress of Endocrinology in Dublin.
Finally, the team grew the tissue in a three - dimensional system, which coaxed it into forming all the structures found in gut tissue, including the finger - like villi that protrude inwards to increase surface area, and recesses called crypts containing the intestinal stem cells that renew the gut lining weekly (Nature, DOI: 10.1038 / nature09691).
They found similar changes in gene expression in the same genes with increased activity of glucose transporters in both the stem cells and the fat cells, Sen noted.
«Our stem cell - based studies indicate that low - calorie sweeteners promote additional fat accumulation within cells compared with cells not exposed to these substances, in a dose - dependent fashion — meaning that as the dose of sucralose is increased more cells showed increased fat droplet accumulation,» said Sabyasachi Sen, M.D., Associate Professor of Medicine at George Washington University in Washington, D.C. «This most likely occurs by increasing glucose entry into cells through increased activity of genes called glucose transporters.»
How sleep apnea is related to these conditions is debated, but Cavadas and her co-authors propose that prolonged disruptions in blood oxygen levels and sleep fragmentation can generate stem cell exhaustion, epigenetic changes, increased inflammation, and other hallmarks of aging.
He noted that even the Obama administration's 75 approved stem cell lines (increased from the Bush administration's 21) are not enough for robust research in the field.
Suzuki and his group hope that by further manipulating the chemical environment of the spheres of stem cells, they may increase that number, further easing the path toward human treatment.
Increasing levels of PUMA only affected stem - like cells that were starting to spread and not the growth of primary tumors.
Looking further into the intestinal crypts of both the transgenic and wild - type mice, the research team made what they consider a surprising finding: Not only was HMGA1 causing the stem cells themselves to self - renew or proliferate more rapidly in the transgenic animals, but it was also increasing the number of Paneth cells, a type of niche cell known to support intestinal stem cells.
When these enveloped cells were injected into mouse and pig hearts, the researchers observed increased cell retention and regeneration compared to directly injecting just the stem cells.
Loss of either GSTO1 or RYR1, the researchers report, decreased the number of cancer stem cells in the primary tumor, blocked metastasis of cancer cells from the primary tumor to the lungs, decreased the duration of chemotherapy required to induce remission and increased the duration of time after chemotherapy was stopped that the mice remained tumor - free.
Recent studies showed that low oxygen conditions increase levels of a family of proteins known as HIFs, or hypoxia - inducible factors, that turn on hundreds of genes, including one called NANOG that instructs cells to become stem cells.
The cells aggregate and return to a stem cell - like state to allow them to increase in numbers and generate the specialised cells needed for new tissue formation
When the researchers manipulated the cell's genetics to increase levels of ALKBH5 without exposing them to low oxygen, they found this also decreased methylation of NANOG mRNA and increased the numbers of breast cancer stem cells.
There is increasing evidence that this is due to the presence of cancer stem cells — cells that reproduce indefinitely and may seed new tumors.
Bone marrow mesenchymal stem cells and bone cells from the skulls of Cbf - beta - deficient mice showed increased expression of adipocyte genes.
They find that tumors lacking Numb have increased numbers of cancer stem cells, thus providing the tumor with a higher potential to spread and grow.
The CIRM funding increases the ties between Californian and Australian stem cell science.
Dr. Qu said not only did disc height increase, but stem cell transplant also increased disc water content and improved appropriate gene expression.
«Active HSCs (hematopoietic stem cells) form the daily supply line that continually replenishes worn - out blood and immune cells while the reserve pool serves as a backup system that replaces damaged active HSCs and steps in during times of increased need,» explains Li.
«We see this mild increase in Aβ42 in cells from patients with Alzheimer's disease, which seems to be enough to trigger disease processes,» said Young - Pearse, a Harvard Stem Cell Institute - affiliated faculty member at Brigham and Women's Hospital.
«In both models, the increased number of blood cells can be attributed to a greater reserve population of stem cells.»
The team found that individuals with long - standing type 1 diabetes and diabetic enteropathy have altered colonic stem cells (CoSCs) and increased blood levels of a regulatory protein called insulin - like growth factor binding protein 3 (IGFBP3), which is produced in the liver.
Plant researchers at VIB and Ghent University have now identified a new molecular network that increases our understanding of stem cell regulation and activity.
Therefore, adult stem cells become exhausted in aged individuals due to telomere length shortening that results in increased healing times and organ tissue degradation from inadequate cell populations.
Small molecule drugs can be screened or designed to increase telomerase activity exclusively within stem cells for disease treatment as well as anti-aging therapies without increasing the risk of cancer.
Dr Mohamed Elrayess, from ADLQ, said: «In this study we have shown that the impaired ability of fat stem cells to store excess fat was partially due to increased levels of the inflammatory marker interleukin - 6 in the blood.
Yet, this increases the probability that the other stem cells in the root stem cell niche will die due to the cold, leading to the plant's death.
The researchers confirmed Olig2's role in promoting motor neuron formation by increasing or blocking the function of Olig2 in the spinal cords of developing mouse and chicken embryos, as well as during motor neuron formation in mouse embryonic stem cells.
«We believe that BPA actually reprograms the stem cells to be more sensitive to estrogen throughout life, leading to a life - long increased susceptibility for diseases including cancer,» Prins says.
«We believe that BPA actually reprograms the stem cells to be more sensitive to estrogen throughout life, leading to a life - long increased susceptibility to diseases including cancer,» Prins said.
By doing this, we increased the efficacy of the treatment and we believe that in turn the treatment targeted the stem cells, which are the basis of recurrence.
Prostate stem cells, which are very long - lived, pass on the increased estrogen sensitivity to the prostate tissues they produce throughout life.
Jasper, who is now a staff scientist at Genentech, says this activation is important for rapid tissue repair, but at the same time it also increases the probability that stem cells will differentiate, thus losing their stem cell status.
«We're looking at the genes and gene networks involved in stem cell proliferation, meristem development and flowering and branching,» said Van Eck, «with the end goal being that maybe genes that we identify in tomato, which is strictly being used as a model, might help us understand what can be done to increase yield in other crops.»
Neuroscientists Jing Wang and Freda Miller, both then at Toronto's Hospital for Sick Children, showed that when nondiabetic mice are given metformin, their memory improves, thanks to an increase in the neural stem cell population and in the number of these cells that develop into healthy neurons in the hippocampus, the brain's memory center.
The team discovered that the TCL1 protein played a key role in increasing glycolysis by activating a different metabolic pathway that is important for the self - renewal of stem cells.
The scientists found that celecoxib directly increased stem cell differentiation into keratinocytes — skin cells required for wound healing.
During the initial stages of typical brain development, stem cells go through a period in which they divide to make more stem cells, increasing their numbers.
A research team has identified a protein that increases the transfer of mitochondria from mesenchymal stem cells to lung cells.