Sentences with phrase «stem cells infected»

In collaboration with Ding, the lab of Olivier Voinnet at the Swiss Federal Institute of Technology in Zurich also reported in an accompanying paper the detection of viral siRNAs in cultured mouse embryonic stem cells infected by the Encephalomyocarditis virus.

Not exact matches

In human cells and in mice, the virus infected and killed the stem cells that become a glioblastoma, an aggressive brain tumor, but left healthy brain cells alone.

Using human fetal «mini-brains» grown in 3 - D cultures, scientists determined that a specific protein produced by the Zika virus changes the properties of neural stem cells in the developing brain of an infected fetus, potentially causing microcephaly in newborns (Ki - Jun Yoon, abstract 103.06, see attached summary).

The virus does this because, unlike most microbes, Zika can pass from blood into the brain, where it infects and kills stem cells, having severe effects on developing brains.

When it reaches the brain, Zika virus infects neuronal stem cells, which will generate fewer neurons, and by inducing chronic stress in the endoplasmic reticulum, it promotes apoptosis, i.e. the early death of these neuronal cells.

But this ability to infect brain stem cells may prove useful for fighting deadly brain cancers, many of which are caused by mutated stem cells.

Confocal microscopy of human neural stem cell culture infected with Zika virus (red).

The two reports also showed that Zika virus infected and damaged neuronal stem cells harvested from mice and humans.

A Zika - infected organoid (right) shows collapse of the rosette, with fewer neural stem cells and neurons.

«This is such a prevalent virus... about 25 percent of stem cell transplant patients get infected [with rhinovirus] during the first year,» said Boeckh, who heads Fred Hutch's Infectious Disease Sciences Program.

Through gene therapy, researchers engineered blood - forming stem cells (hematopoietic stem / progenitor cells, or HSPCs) to carry chimeric antigen receptor (CAR) genes to make cells that can detect and destroy HIV - infected cells.

Researchers have been seeking a way to improve the body's ability to combat the virus by engineering blood - forming stem cells to specifically target and kill HIV - infected cells for the life of the individual.

Because HIV uses CD4 to infect cells, the researchers used a CAR molecule that hijacks the essential interaction between HIV and the cell surface molecule CD4 to make stem cell - derived T - cells target infected cells.

«Zika virus infects human neural stem cells.»

One concerning discovery was that the stem cells that Zika was found to infect, called cortical neural precursors, become factories for viral replication.

The approach enabled a wide range of studies of human brain development, including implicating a new class of neural stem cell recently discovered by the lab in the evolutionary expansion of the human brain and identifying how the mosquito - borne Zika virus may contribute to microcephaly in infants infected in utero.

VIRUS VICTORY Zika virus (green) infects and kills stem cells (red) in human glioblastoma tissue, without infecting healthy brain cells.

The Zika virus infects a type of neural stem cell that gives rise to the brain's cerebral cortex, Johns Hopkins and Florida State researchers report March 4 in Cell Stem Cstem cell that gives rise to the brain's cerebral cortex, Johns Hopkins and Florida State researchers report March 4 in Cell Stem Ccell that gives rise to the brain's cerebral cortex, Johns Hopkins and Florida State researchers report March 4 in Cell Stem CCell Stem CStem CellCell.

Viral agents then burst out of the stem cells, infecting the cancer tissue — but leaving healthy brain tissue alone.

Coxsackie B virus (red) infects cells positive for the heart stem cell marker Sca - 1 (green).

Both strains spread through the tumors, infecting and killing the cancer stem cells while largely avoiding other tumor cells.

To test whether the childhood infection and stem cell depletion had any effect on the adult heart, the researchers exposed infected mice to two different types of cardiac stress.

When comparing the numbers of cardiac stem cells in previously infected adult mice with uninfected ones, the researchers found significantly smaller numbers in the infected mice.

And the field now knows that a cure is indeed possible because of an unusual stem cell transplant in one HIV - infected person with leukemia who no longer has any detectable virus in his body.

Studying a new type of pinhead - size, lab - grown brain made with technology first suggested by three high school students, Johns Hopkins researchers have confirmed a key way in which Zika virus causes microcephaly and other damage in fetal brains: by infecting specialized stem cells that build its outer layer, the cortex.

In addition, transgenic autologous hematopoietic stem cells can be successfully transplanted in HIV - infected individuals [18] and several phase I adoptive transfer trials of CD4 + T cells treated with R5 - ZFNs in HIV infected individuals are currently underway.

Aiuti and his team harvested stem cells from the infants and then infected those cells with an engineered virus carrying healthy copies of the missing gene.

His laboratory and their collaborators have also identified human amyloid fibrils in semen that enhance the ability of HIV to infect new cells — a discovery that one day could help stem the global spread of this deadly pathogen.

Recently, Dr. Greene's lab identified human protein fragments in semen that enhance the ability of HIV to infect new cells — a discovery that one day could help stem the global spread of this deadly pathogen.

In that context, the goal of this project is to infect relevant human host cells (monomacs, neuronal stem cells and differentiated neurons) with parasites of differing lineages to generate transcriptional mRNA and miRNA profiles.

The first reports that gene - editing of bone marrow stem cells in monkeys infected with a variant of simian immunodeficiency virus (SIV) significantly reduces the number of dormant «viral reservoirs» that pose a risk of reactivation.

Human immunodeficiency virus (HIV) can infect bone marrow cells — including, possibly, hematopoietic stem cells, according to a study published online today (March 7) in Nature Medicine.

Working with lab - grown human stem cells, scientists found that the virus selectively infected cells forming the brain's cortex, the thin outer layer of folded gray matter.

Strengthening the link between Zika virus and microcephaly, scientists at UC San Francisco have discovered that a protein the virus uses to infect skin cells and cause a rash is present also in stem cells of the developing human brain and retina.

The first reports that gene - editing of bone marrow stem cells in monkeys infected with a variant of simian immunodeficiency virus (SIV) significantly reduces the number Read more about Gene - editing and vaccines could improve HIV treatment - Scimex

Guido Silvestri, MD, division chief of Microbiology and Immunology at the Yerkes Research Center at Emory, and several of his research colleagues performed the first hematopoietic stem cell transplantation in three rhesus macaques infected with a simian human immunodeficiency virus (SHIV).

Many have used viruses to convert adult cells to stem cells and to carry a normal HBB gene to infect and repair hematopoietic stem cells — stem cells that give rise to all blood cells.

The team of researchers harvested hematopoietic stem cells from three macaques prior to SHIV infection of all six animals in the study, treated the animals with anti-retroviral therapy (ART) to reduce viral load and mimic the situation in human HIV - infected patients who are treated with ART, and then exposed the three monkeys from which they had collected hematopoietic stem cells to a high dose of radiation.