According to Puzas, teriparatide significantly speeds up fracture healing by changing the behavior and number of the cartilage and the bone
stem cells involved in the process.
Additional trials were excluded from consideration if their only relationship to
stem cells involved now - conventional unmanipulated bone marrow or cord blood transplants.
Not exact matches
One way to enhance eggs, developed by the company OvaScience,
involves supplementing an egg with mitochondria taken from
stem cells found in the lining of a woman's uterus.
The author says the moral cost
involved is the reason why she believes embryonic
stem cell research is not consonant with Christian faith.
The increasing use of in - vitro - fertilisation techniques, and the emergence of new possibilities
involving human cloning, mixing of human and animal genetic elements, and the use of embryonic
stem cells for research, among other things, brought the need for further teaching.
When I entered the United States Senate in 1996, I had no idea that I would eventually consider
stem cell research as one of the most important policy issues in which I am
involved.
«There are perfectly ethical ways of obtaining
stem cells to cure disease, which do not
involve embryo destruction, so no matter what moral value one places on the human embryo, we do not need to use it.»
Former Governor Martin O'Malley (D — MD) has supported
stem -
cell research
involving human embryos (although he is a devout member of the Catholic Church, which has opposed many forms of embryonic
stem cell research).
The process is painstaking and
involves the systematic «knockout» — removal — of relevant genes in
stem cell cultures.
Marcelo Rivolta of the University of Sheffield in the UK and colleagues extracted cochlear
stem cells from aborted fetuses, with the consent of the women
involved.
The relevant patents
involve the positioning of differentiated retinal
cells in the eye and not the creation of these
cells and would potentially be exempt from the ruling; his team wrote its patent this way to distinguish it from other
stem -
cell - based applications — they felt that describing the placement of
cells rather than the creation of the
cells was likely to be more novel.
«It was particularly exciting to observe that the repair of the skin epidermis
involves the activation of very different
stem cells that react the same way to the emergency situation of the wound and have the power to completely restore the damaged tissue», comments Mariaceleste Aragona, the first author of the study.
«I think this is the best option we have ever had,» says Renee Reijo Pera, director of Stanford University's Center for Human Embryonic
Stem Cell Research and Education in California, who wasn't
involved in the study.
Procedures that
involve human embryonic
stem cells can not be patented, the European Court of Justice declared today.
In March, advocate general Yves Bot issued a preliminary judgment limiting patents
involving embryonic
stem cells, on the basis that they «would be contrary to ethics and public policy» (see «European Court of Justice rejects
stem -
cell patents»).
Existing European patents
involving embryonic
stem cells — most of which were issued in the United Kingdom — will not be invalidated immediately, but lawsuits challenging individual patents will use the ruling as guidance.
«And around the world we'll see stimuli to get
involved in
stem cell work,» Burrill predicts.
Research
involving the derivation and use of
stem cells from adult tissues is permissible, subject to the informed consent of the tissue donor.
Research
involving the derivation and use of embryonic
stem (ES)
cells is permissible only where there is strong scientific merit in, and potential medical benefit from, such research.
The study «provided the surprising result that one new therapy currently being explored to lower insulin resistance promotes, rather than decreases, the formation of bone in mice,» says Darwin Prockop, a
stem cell researcher at Texas A&M College of Medicine in Temple, who was not
involved in the work.
They then argue that «By creating a financial incentive for embryonic
stem cell research — an incentive that by NIH's own admission
involves investments of «hundreds of millions of dollars» — and by specifying the precise means by which embryos must be destroyed in order to qualify for federal funding, the NIH necessarily and knowingly subjects embryos to a substantial risk of injury or death.»
Research
involving the derivation and use of
stem cells from cadaveric foetal tissues is permissible, subject to the informed consent of the tissue donor.
Researchers at the University of Louisville have discovered a mechanism
involved in skeletal muscle repair that may enable clinicians to boost the effectiveness of adult
stem cell therapies for diseases such as muscular dystrophy.
«Cardiac
stem cells from heart disease patients may be harmful: Researchers discover molecular pathway
involved in toxic interaction between host
cells and immune system.»
Her future work will
involve learning more about the role of
stem cells in healing so that we can one day use them in the clinic.
Svendsen is more optimistic about his team's work
involving human tests of a novel
stem cell approach to treat ALS, a degenerative motor neuron disease in which
cells that transmit messages from the brain and spinal cord to the muscles wither or die.
Several studies have supported a role for cancer
stem cells in the aggressive brain tumors called glioblastoma, but those studies
involved inducing human tumors to grow in mice, and as such their relevance to cancer in humans has been questioned.
The new rules state that
stem cells can be used if they are part of a study approved by the federal government, or if the protocol has been approved by an Institutional Review Board (IRB) that provides ethical review for research
involving human volunteers.
Directing
stem cell differentiation is like following a complex recipe,
involving a long list of ingredients and steps that make the process costly and inefficient.
The theory that cancer progression
involves the acquisition by tumor
cells of features similar to those of
stem cells has gained strength in the scientific community.
Now, many research advocates are wondering how Price's mix of views might play out in the new administration's approach to a wide range of issues, including funding, research
involving human embryonic
stem cells and fetal tissue, and the appointment of a new NIH director.
There are now other methods to make
stem cells, but those made via SCNT have unique value because they are genetic copies of the living person who donated the skin
cells (other methods either use foreign
cells or
involve genetic reprogramming).
But a number of the invited speakers, including Alan Trounson, president of the California Institute for Regenerative Medicine in San Francisco, and keynote speaker George Daley, a
stem -
cell scientist at Children's Hospital Boston in Massachusetts, are
involved in research using human embryonic
stem cells, which the Catholic Church considers unethical.
► The U.S. National Institutes of Health (NIH) has put funding on hold for experiments that
involve «mixing human
stem cells into very early animal embryos and letting them develop» while it «reconsiders its rules» for this type of research, Gretchen Vogel reported Wednesday.
The human version of the
cells, called region - selective pluripotent
stem cells, or rsPSCs, can also grow inside a mouse, something other human
stem cells can't do, says Jun Wu, a research associate
involved in the work, published in May in Nature.
In August, federally funded work on
stem cells was temporarily suspended after a judge ruled that work on hESCs violates a legal amendment in 1995 forbidding funding of any experiments that
involve destruction of human embryos.
But the case shows that even patients who feel they have nothing to lose should be cautious, says Leigh Turner of the University of Minnesota in Minneapolis, who tracks lawsuits
involving stem cell therapies.
Now, with new kinds of technologies that are coming up, new types of tissue engineering and, you know, some of the hopes that people have for
stem cells and [the] like, it may be interesting to see if there are other ways, alternatives to dealing with really badly damaged hearts that would
involve growing a new heart or replacing or repairing the damage d to a badly damaged heart that might make artificial hearts less important in the somewhat more distant future.
No results from trials
involving stem cells and multiple heart attack patients had yet been published.
To see whether cancer
stem cell renewal
involves a chain of events similar to that used by embryonic
stem cells, and whether the process was affected by oxygen levels, Semenza and graduate student Chuanzhao Zhang focused their studies on two human breast cancer
cell lines that responded to low oxygen by ramping up production of the protein ALKBH5, which removes methyl groups from mRNAs.
What federal oversight should embryonic
stem cell research have that other forms of biomedical research, including those
involving human subjects, do not already have?
The disease model, described in a new study by a UC San Francisco - led team,
involves taking skin
cells from patients with the bone disease, reprogramming them in a lab dish to their embryonic state, and deriving
stem cells from them.
Many genes that are
involved in the growth and development of embryos or adult
stem cells also play roles in cancer, Resar adds.
For example, one method
involves directly implanting
stem cells in the heart wall, but the
cells often don't take hold, and sometimes they trigger an immune reaction.
Those hoping for quick clinical success should remember it takes time for revolutionary treatments to go from lab bench to bedside, says Andras Nagy, a
stem cell researcher at Mount Sinai Hospital's Lunenfeld — Tanenbaum Research Institute in Toronto, who has not been directly
involved in Yamanaka's work.
Further investigation, says Resar, showed that these unusual properties arise from the ability of HMGA1 to turn on several genes
involved in the Wnt pathway, a network of proteins necessary for embryonic development and
stem cell activity.
Studies of embryonic
stem cells revealed that NANOG protein levels can be lowered by a chemical process known as methylation, which
involves putting a methyl group chemical tag on a protein's messenger RNA (mRNA) precursor.
I mean, you know, the people that are
involved in this, you know, imagine a future where, you know, you can take some
stem cells from a farm animal, grow them and produce meat.
TOKYO — Research
involving human embryonic
stem (ES)
cells will become easier in Japan as a result of new ethical review requirements that take effect today.
Such
cell - tracing techniques are the right approach to test the cancer
stem cell model, says Sean Morrison, who studies
stem cells and cancer at UTSMC and who was not
involved in any of the studies.